The Touyz Lab

We are more than a lab working on vascular biology of cardiovascular diseases, we are a family! Part of @RIMUHC1 @CUSM_MUHC @McGillMed

[Hypertension @HyperAHA]

!Register today! https://t.co/gy2Vkwfsu6
to join mods @AnastasiaSMihai @guto_montezano @carmendemigue12 for a @HyperAHA #HTNImpact Webinar!

May 14, 2025 3pm – 4pm CT

Under Pressure for Accurate BP Measurement – in Human & Animal Models

[CHALProgram @ChalProgram]

Dr Rhian Touyz and her team have identified a previously unrecognized interaction between Ang-(1-7) and Endothelin-1.

@LabTouyz

Read more about the discovery here: https://t.co/DxD7jcFqKy

#research #cardiology

[EACARE_RI-MUHC @MuhcRi]

At THE INSTITUTE @rimuhc @RIMUHC1, I am passionate about cardiovascular research and medicine and my quest to unravel molecular mechanisms of hypertension. @LabTouyz @ChalProgram @MuhcRi

[CHALProgram @ChalProgram]

Congratulations to @RIMUHC1 @ChalProgram researchers Dr. Daskalopoulou, Dr. Mavrakanas, Dr. Pilote, Dr. Sharma and Dr. Touyz for their successful @CIHR_IRSC 2024 Fall applications.

@PiloteDr
@DREAMCVLAB1
@LabTouyz

https://t.co/lq4kNx2Jxs

#grants #research

[Nature Communications @NatureComms]

This study assesses current global ozone pollution and reveals significant O₃-related health risks, with key focuses on population exposure and all-cause mortality burden, using the high-resolution estimation from a geo-ensemble learning model https://t.co/YvI5NHPBHm

[Francisco Rios @fjorios]

In a few minutes, we will start the #HYPHIP @HyperAHA
chat with the author @yixi_sun . We will discuss how metabolomic approach can help to understand hypertension development. @AHAScience

[Francisco Rios @fjorios]

CORRECTION this #HYPHIP chat will start in 2.5h. Hope to see you there. @AnastasiaSMihai @guto_montezano @Carmendemigue12 @DrDudenbostel @HyperAHA

[Dr. Heddwen Brooks, PhD, AJP-Renal Editor-in-Chief @AJPRenalEIC]

Thank you @FZMarques 10 brilliant women in STEM! Pick it up, keep moving and follow these women👇 @Zuloaga_Lab @jenpluznick @MLGumz @hollyingrahamSF @LicyYanes @LacyMAlexander @EleanorLederer @DrDeidraCrews @MLSequeiraLopez @LabTouyz

[Dr Anastasia Mihailidou FAHA FCSANZ FESC @AnastasiaSMihai]

Hope that you will join our @AHAScience @HyperAHA #HypHIP Live Chat with 💫💫 authors @eileenkaur14 & @KuniMatsushita on the 🚨topic of #BloodPressure arm cuff size & implications for 🇺🇸 adult detection & management of #Hypertension

[Dr Anastasia Mihailidou FAHA FCSANZ FESC @AnastasiaSMihai]

🚨Please join me, @guto_montezano @DrDudenbostel @Carmendemigue12 @fjorios next wk fr @HyperAHA #HYPHIP Author chat which is 🌟

First author publication for @eileenkaur14 👏👏

A First for #Hypertension & possibly most #CardioEd journals - Eileen is still completing her high school degree !!

Congratulations Eileen👏👏 & look fwd to our chat with you & head of unit @KuniMatsushita

[M L Sequeira-Lopez @MLSequeiraLopez]

UVA Researchers Hope To Flip the Switch on Blood Pressure Control https://t.co/qGzJBYjRQZ
https://t.co/WZ6QgsXUp0

[Francisco Rios @fjorios]

#Hypertension24 - @LabTouyz from @RIMUHC1 presented their latest data from @guto_montezano showing how Notch3 in VSMCs regulates adipocyte-vasculature interactome. @quelsarafian @AHAMeetings @AHAScience @HyperAHA @CouncilonHTN @LeducqCardioBAT

[Dr Anastasia Mihailidou FAHA FCSANZ FESC @AnastasiaSMihai]

@rosam_bruno 🔦how the new
@escardio 2024 ESC Guidelines for Mgt of Elevated #BloodPressure & #Hypertension recommendations for when to start drug treatment & new BP treatment targets

♥️ infographics which can be posted on clinic & waiting rooms etc

@johnwmcevoy @labtouyz

[CJC Journals @CJCJournals]

🔓 For a limited time until August 21, we are offering free promotional access to read the covering editorial for the newest issue of #CJC! 👇
Aging, through knowledge and wisdom: https://t.co/zBoIp0GIgv 🌐

[The Touyz Lab @LabTouyz]

@DrDudenbostel @guto_montezano @HyperAHA @AnastasiaSMihai @Carmendemigue12 @fjorios Many thanks for the opportunity to highlight our study- and a big recognition of thanks to all the co-authors who contributed to the study

[The Touyz Lab @LabTouyz]

A8.3. So much more exciting work to be done to learn more about Notch3 and small vessel disease, beyond CADASIL. Thanks so much for the opportunity to highlight our study #HypHIP

[The Touyz Lab @LabTouyz]

A8.2. What is especially exciting is that some of the abnormal Notch3-related pathways we identified may be targets for new therapies, eg. - inhibiting Rho kinase with fasudil (which is used clinically, especially in Japan for subarachnoid hemorrhage) #HypHIP

[The Touyz Lab @LabTouyz]

A8.1. We did not encounter any specific experimental challenges, but recognise we have a lot more work to do. For example, we will study the newNotch3-dependent mechanisms in female mice, especially since PAH is more prevalent in women #HypHIP

[The Touyz Lab @LabTouyz]

A7.2. What is really interesting is that a mutation that causes CADASIL (a small vessel disease of the brain) is also implicated in small vessel injury in PH. #HypHIP

[The Touyz Lab @LabTouyz]

A7. 1. To our knowledge, our data are novel and contribute new molecular mechanisms linking Rho kinase, ER and oxidative stress through Notch3, as processes underlying vascular damage in PH. I don't think our data contradict previous studies. #HypHIP