Wilhelm Lab

Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn

[Wilhelm Lab @LabWilhelm]

How does obesity disrupt ILC2 function and adipose tissue hoemostasis?
In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.

[Wilhelm Lab @LabWilhelm]

Congratulations to first authors @Fokaragiannis and Rafa Theodorou

[Wilhelm Lab @LabWilhelm]

How does obesity disrupt ILC2 function and adipose tissue hoemostasis?
In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.

[Wilhelm Lab @LabWilhelm]

We show that excess lipids in obesity suppress ACC1 in adipose ILC2s. Our findings also point towards an unexpected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance.

https://t.co/Pcu3m8vBSM
https://t.co/Pcu3m8vBSM

[Wilhelm Lab @LabWilhelm]

Congratulations to first authors @Fokaragiannis and Rafa Theodorou!

[Wilhelm Lab @LabWilhelm]

Our findings also point towards an unexected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. https://t.co/Pcu3m8vBSM

[Cell Metabolism @Cell_Metabolism]

New! Online now: Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health https://t.co/vhbCrYEY41

[SchabbauerLab @SchabbauerL]

We are excited to see our beloved study on Macrophage Arginine metabolism in Neuroinflammation published today in #NatureImmunology.
https://t.co/cpfPdS30E9.
It is time to celebrate 🍷🍻🥂

[Wen Zhang @wenzhang1120]

Honored to see our recent Nature study on neuro-epithelial circuits in anti-helminth immunity highlighted in this excellent News & Views. Many thanks to the authors @LabWilhelm for the thoughtful synthesis.
https://t.co/CG6JkFQoQg

[Elizabeth Emanuel @immunologyliz]

A nice write-up from Nature Immunology about our recent paper!

https://t.co/kEx4fIBD7N

[Wilhelm Lab @LabWilhelm]

Our new paper out in @ImmunityCP Congratulations to first author Chantal Wientjens! https://t.co/dTF5c6y7gT

[Wilhelm Lab @LabWilhelm]

Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione
synthesis to prevent #ferroptosis and
support #lipid metabolism and expansion of type 2 immune cells in #asthma.

[Immunity @ImmunityCP]

Online now: Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation https://t.co/jBwFYwo6fx

[Wilhelm Lab @LabWilhelm]

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology https://t.co/dxk9z5593E

[Wilhelm Lab @LabWilhelm]

Alaaf!! 🎊🍾🥳🥳🥳

[Wilhelm Lab @LabWilhelm]

@richnanophd Thanks so much, really appreciate it.

[Wilhelm Lab @LabWilhelm]

We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.

[Dagmar Wachten & lab @DagmarWachten]

Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation

[Wilhelm Lab @LabWilhelm]

Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens

[DFG public | @[email protected] @dfg_public]

Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:
➡️https://t.co/kXJWN77KRp

[Waggoner Lab @LabWaggoner]

Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando
@TimMcCulloch https://t.co/aev8ZBefxb

[Laura Surace @surace_laura]

🚨 last weeks 🚨
1 phd position available in our Lab !
If you are interested in tumor immunology and immunometabolism contact us … info 👇 … 🙏 RT