LabWitwer

All about enveloped #viruses and other #ExtracellularVesicles as well as extracellular RNA #exRNA

[Denis Wirtz @deniswirtz]

Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in research grants issued by federal agencies

NIH: -57% in the number of awards and -63% in value compared to FY24

[Kenneth W Witwer (he/him) @KennethWWitwer]

At the next #EVClub with #EViNS, Hermine Counil presents "Brain penetration of peripheral #ExtracellularVesicles from #Alzheimer's patients and induction of #microglia activation"
Wed July 16, 12 noon EDT/18.00 CEST/midnight Beijing
Need the login? https://t.co/rlKrHdZU3I
https://t.co/doy0qHRavy
Can't join the call? Recording available ASAP on the ISEV YouTube channel: https://t.co/gk8vFZRotr
@ISEV_Journals @LabWitwer

[Zach Troyer @Troymen11]

Excited to try out our new Ascent automated SEC instrument from @everestbiolabs here in the @LabWitwer @KennethWWitwer #ExtracellularVesicles

[Kenneth W Witwer (he/him) @KennethWWitwer]

Although #ExtracellularVesicles have strong promise in #LiquidBiopsy, EVs from specific sources can be difficult to find, like a needle in a haystack. In this #EVClub, Agustin Enciso-Martinez et al present a solution they have found and validated in pancreatic adenocarcinoma.
When? Wed July 2, 12 noon EDT/18.00 CEST
Need the login? https://t.co/rlKrHdZU3I
See: https://t.co/to1tliZya6
Can't join the call? The recording will available ASAP on the ISEV YouTube channel: https://t.co/gk8vFZRotr

[Kenneth W Witwer (he/him) @KennethWWitwer]

Engineering #ExtracellularVesicles for Efficient Delivery of Therapeutics and Genome Editors
At the next #EVClub, Xiuming Liang presents recent J Controlled Release and Nature Communications papers from the @SamirAndaloussi group
Wed June 4, 12 noon EDT/18.00 CEST
Need the login? https://t.co/Dxv8by4yyA
Archive available ASAP on the ISEV YouTube channel: https://t.co/gk8vFZRotr
@IsevOrg @LabWitwer @NatureComms #ISEV

[Kenneth W Witwer (he/him) @KennethWWitwer]

At the next #EVClub, Silvia Cappello addresses molecular cues trafficked by #ExtracellularVesicles during human brain development https://t.co/gGnEG1ErXK
Wed March 19 12 noon EST/17.00 CET
Need the login? https://t.co/rlKrHdZU3I

Moderated by Tsuneya Ikezu and #EViNS, the Extracellular Vesicles in Nervous Systems Special Interest Group of #ISEV
Can't join the call? The recording will available ASAP on the ISEV YouTube channel: https://t.co/gk8vFZRotr
@IsevOrg @LabWitwer

[Kenneth W Witwer (he/him) @KennethWWitwer]

At the next #EVClub, Joseph Brealey shines "a light on fluorescent EV dyes: Evaluating efficacy, specificity and suitability by nano-flow cytometry" https://t.co/ei59Jb4xxp
Wednesday, Feb 26, 12 noon EST/18.00 CET
Need the login? https://t.co/rlKrHe0rTg
Can't join the call? The recording will available ASAP on the ISEV YouTube channel: https://t.co/gk8vFZRWiZ
@IsevOrg #ISEV #NFCM @LabWitwer @ISEV_JExBio @ISEV_Journals

[Kenneth W Witwer (he/him) @KennethWWitwer]

This week's #EVClub is all about how #ExtracellularVesicles factor into #coagulation. We review "A century of evidence for highly coagulant tissue factor/activated factor VII complex-exposing EVs in body fluids" with Johannes Thaler, Carla Tripisciano, and Rienk Nieuwland.

See also: https://t.co/7WNB01y72l and https://t.co/haOX8pMGlh

Wed 12 noon EST/18.00 CET

Need the login? Sign up: https://t.co/Dxv8by56o8

@IsevOrg @LabWitwer

[Kenneth W Witwer (he/him) @KennethWWitwer]

Great turnout for the January #EViNS #EVClub. Carla Lopes presenting her work on #iPSC-derived neuronal models of Huntington's disease and treatment with #ExtracellularVesicles
https://t.co/lyvFEyAH2w
This will be archived at: https://t.co/MO9sVpEDRO
To sign up for EVClub: https://t.co/rlKrHe0rTg

#ISEV @IsevOrg @TsuneyaIkezu Christian Neri @LabWitwer

[Kenneth W Witwer (he/him) @KennethWWitwer]

This week's #EVClub features an intriguing preprint on "Direct intercellular vesicle exchange between adjacent cells"
https://t.co/JPuU1X15gV
With Jun Yamashita, Tomohiro Minakawa, and Mima Shikanai
Wednesday Feb 19, 11 AM Japan, 10 AM Beijing, 1 PM Melbourne and Tuesday Feb 18, 9 PM EST
Need the login? https://t.co/rlKrHe0rTg
Archive available ASAP on the ISEV YouTube channel: https://t.co/MO9sVpEDRO
@IsevOrg @LabWitwer and thanks to @Pluchinolab

[Kenneth W Witwer (he/him) @KennethWWitwer]

ICYMI: #EVClub of #ISEV and #EViNS. Carla Lopes presents “#ExtracellularVesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons” (Theranostics, 2023)
@IsevOrg
https://t.co/YAAsx3kKiu

[Kenneth W Witwer (he/him) @KennethWWitwer]

An exciting next #EVClub with #GUSEV: identifying cell sources of #ExtracellularVesicles by transcriptome deconvolution @ISEV_Journals
Per Svenningsen, Jannik Hjortshøj Larsen, Iben Skov Jensen
Wednesday, December 18, 12 noon EST/1800 CET
Need the login? https://t.co/rlKrHdZU3I
moderation by @DSchnekenB @flscientist @CristinaGrange
Can't join the call? The recording will available ASAP on the ISEV YouTube channel: https://t.co/MO9sVpE62g
https://t.co/bIMGvfEucX
@IsevOrg @LabWitwer

[Kenneth W Witwer (he/him) @KennethWWitwer]

At the next #EVClub, we learn from Carla Lopes about #ExtracellularVesicles and Huntington's disease #iPSC neurons https://t.co/lyvFEyAH2w
Wednesday, January 15, 12 noon EST/18.00 CET
Need the login? https://t.co/rlKrHe0rTg
A collaboration with #EVINS, the @IsevOrg special interest group on #EVs in Nervous Systems. Intro/moderation by @TsuneyaIkezu @Neri_lab thanks to @Pluchinolab for organizing
Can't join the call? The recording will available ASAP on the ISEV YouTube channel https://t.co/gk8vFZRWiZ
#ISEV #HuntingtonsDisease @LabWitwer

[ISEV @IsevOrg]

🖋️ Sharpen your pens!
✅ Submit your Late Breaking Abstract for #ISEV2025 between 13 January - 2 February!
🐤 ..and don't forget to register, Early Bird fees last until 3rd of March
https://t.co/eF5bPJJ6tr

@albers_eva @AnHendrix2 @editbuzas @LLanguino @LeeRetinaLab

[Indian Society for Extracellular Vesicles @insev_soc]

Announcing many Exciting Awards for Young Researchers at EVOLVE 2025!🏅🏅🏅
Do Register and Submit your Abstracts ASAP to be the winners!
Indian Society for Extracellular Vesicles (InSEV)
https://t.co/BuDJzrP9Do

[Kenneth W Witwer (he/him) @KennethWWitwer]

Excellent comment about core facilities. They add dimensions to research programs. You can train with world leaders in specific techniques or entirely hand over specific experiments, measurements, and analysis. The value added is not easily reduced to money, either.

[Kenneth W Witwer (he/him) @KennethWWitwer]

This #EVClub was with @ColinHisey, who presents:
“Light-induced Extracellular Vesicle and Particle Adsorption (LEVA) Enables Tunable Micropatterning of EVs for Biomedical Applications”
#ExtracellularVesicles @IsevOrg @Troymen11 @LabWitwer
https://t.co/Mlhxhz5V5D

[Zach Troyer @Troymen11]

@EditBuzas gives a fascinating talk about a new ectosomal biogenesis pathway of small EVs/exosomes - linked to the autophagosome system! @LabWitwer EXCEL #EVCore education day

[Kenneth W Witwer (he/him) @KennethWWitwer]

Aiden Jurcenko presents his MSE project on high-resolution characterization of #HIV virions and host #ExtracellularVesicles through “STORM-FISHing”. He’s presenting as part of our EVCore facility open house and education day. Really great work, Aiden! @LabWitwer

[LabWitwer @LabWitwer]

https://t.co/tGXyBf27BA

[Kenneth W Witwer (he/him) @KennethWWitwer]

This recent #EVClub was a double-header on new technologies for single-particle and single-molecule detection.
1. @ReateguiLab & Kim Truc Nguyen on "Integrated Antigenic and Nucleic Acid Detection in Single Virions and #ExtracellularVesicles with Viral Content" (https://t.co/Qc150jcyLu)
2. Alexander Johnson-Buck & the @NilsWalterLab on novel single-molecule detection technologies.
Would you like to join the EVClub mailing list? Sign up here: https://t.co/rlKrHe0rTg
@IsevOrg @LabWitwer
https://t.co/j61fom9zYN