!! Recruiting postdocs in deep learning and graphs, dynamical systems, & computational biology to map the context-dependent effects of multicellular programs and pleiotropic proteins in cancer progression. We can provide exciting, first-in-class data! https://t.co/5XUGBggqxY
Early findings from a first-in-human trial of VLS-1488, an oral KIF18A inhibitor, show promising anti-tumor activity in heavily treated ovarian cancer. No dose-limiting toxicities were observed. Presented by Dr. Ecaterina Dumbrava at #ASCO25. #EndCancer
(1/2) A very exciting milestone for @VolastraTx and the field of #Chromosomal_Instability. Early escalation data for our KIF18A inhibitor, VLS-1488, show excellent safety and promising efficacy in heavily pre-treated ovarian cancer patients. https://t.co/oJIf02QtNX
Another elegant study by @eileen_parkes group showing how chronic #cGAS#STING activation from #Chromosomal_instability shapes the tumor microenvironment of esophageal #cancer https://t.co/1q4opV17P1
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇https://t.co/JzFY5OQ2Hx
Congratulations to Dr. Victor R. Ambros, former member of the @dartmouth Dept. of Biological Sciences and Geisel Dept. of Genetics, for being awarded the 2024 #NobelPrize in Physiology or Medicine, for the discovery of microRNA. https://t.co/9CM3egiHeT
Tumor Heterogeneity and Evolution:
Nicholas Navin, Christina Curtis, and Ashley Laughney will address this topic in an educational session at #SABCS24 (December 10-13). Learn more:
https://t.co/jO3Xot2Kfb
@nicholas_navin@cncurtis@LaughneyLab
Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…https://t.co/pNGyLKsmmG...
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1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer#micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture?
https://t.co/3Bykj3xF6H
See also the amazing companion paper by the @SteSantaguida lab! Both shed important new light on this phenomenon. What a day for the field of #chromosomal#instability#CIN
Micronuclear collapse triggers chronic STING signaling that drives metastasis. But how do they rupture?? Beautiful work from the @Samuel_Bakhoum lab, led by brilliant physicist turned hard core cell biologist @melodyDiBona, explains how..
Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse.
Learn more in this week's issue: https://t.co/5VupDYaFVH
Very happy to have DNA O-MAP out!
The DNA version of this work, started from a simple premise: how can we measure the proteome at any genomic loci in (nearly) any cell?
This was a great collaboration with @oligopain, and led by Yuzhen Liu and @CD_McGann.
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