Ashley Laughney

Associate Professor @weillcornell @wcm_MeyerCancer Systems Biology of Metastasis

[Ashley Laughney @LaughneyLab]

!! Recruiting postdocs in deep learning and graphs, dynamical systems, & computational biology to map the context-dependent effects of multicellular programs and pleiotropic proteins in cancer progression. We can provide exciting, first-in-class data! https://t.co/5XUGBggqxY

[UT MD Anderson @UTMDAnderson]

Early findings from a first-in-human trial of VLS-1488, an oral KIF18A inhibitor, show promising anti-tumor activity in heavily treated ovarian cancer. No dose-limiting toxicities were observed. Presented by Dr. Ecaterina Dumbrava at #ASCO25. #EndCancer

[Samuel Bakhoum @Samuel_Bakhoum]

(1/2) A very exciting milestone for ⁦@VolastraTx⁩ and the field of #Chromosomal_Instability. Early escalation data for our KIF18A inhibitor, VLS-1488, show excellent safety and promising efficacy in heavily pre-treated ovarian cancer patients. https://t.co/oJIf02QtNX

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

Join us for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club where Tri-I Computational Biology and Medicine (@cbm_student) graduate student Austin A. Varela (@AustinAVarela) will present a @Nature paper from Sept. 2024!

[Samuel Bakhoum @Samuel_Bakhoum]

Another elegant study by @eileen_parkes group showing how chronic #cGAS #STING activation from #Chromosomal_instability shapes the tumor microenvironment of esophageal #cancer https://t.co/1q4opV17P1

[Ashley Laughney @LaughneyLab]

@NeilVasan @nyulangone @Perlmutter_CC Love this! Congrats Neil!!

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

We hope to see you Thursday for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club presented by @cbm_student @EthanEarlie on Thursday, April 24th from 3-4 pm in Belfer #1401 and via Zoom (DM for details)!

[Ashley Laughney @LaughneyLab]

@elhamazizi Congrats Elham!! So proud of you!!

[Ashley Laughney @LaughneyLab]

@KarunaMDPhD @Nature @andrewrmoorman @elliebenitez11 @f_cambuli @KarunaGaneshLab @Dana_Per Big congratulations @KarunaMDPhD and @dana_peer!

[Juan Cubillos-Ruiz @JCubRuiz]

Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇https://t.co/JzFY5OQ2Hx

[Geisel School of Medicine at Dartmouth @GeiselMed]

Congratulations to Dr. Victor R. Ambros, former member of the @dartmouth Dept. of Biological Sciences and Geisel Dept. of Genetics, for being awarded the 2024 #NobelPrize in Physiology or Medicine, for the discovery of microRNA. https://t.co/9CM3egiHeT

[SABCS @SABCSSanAntonio]

Tumor Heterogeneity and Evolution:
Nicholas Navin, Christina Curtis, and Ashley Laughney will address this topic in an educational session at #SABCS24 (December 10-13). Learn more:
https://t.co/jO3Xot2Kfb
@nicholas_navin @cncurtis @LaughneyLab

[Nicholas McGranahan @NickyMcGranahan]

Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…https://t.co/pNGyLKsmmG...
🧵below

[Samuel Bakhoum @Samuel_Bakhoum]

1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture?
https://t.co/3Bykj3xF6H

[Ashley Laughney @LaughneyLab]

See also the amazing companion paper by the @SteSantaguida lab! Both shed important new light on this phenomenon. What a day for the field of #chromosomal #instability #CIN

[Ashley Laughney @LaughneyLab]

Micronuclear collapse triggers chronic STING signaling that drives metastasis. But how do they rupture?? Beautiful work from the @Samuel_Bakhoum lab, led by brilliant physicist turned hard core cell biologist @melodyDiBona, explains how..

[Science Magazine @ScienceMagazine]

Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse.

Learn more in this week's issue: https://t.co/5VupDYaFVH

[Devin Schweppe @dschweppe1]

Very happy to have DNA O-MAP out!

The DNA version of this work, started from a simple premise: how can we measure the proteome at any genomic loci in (nearly) any cell?

This was a great collaboration with @oligopain, and led by Yuzhen Liu and @CD_McGann.

1/8🧵

[Juan Cubillos-Ruiz @JCubRuiz]

Our new study, published today @CD_AACR, reveals that iron chelation therapy unleashes innate immune responses that control #OvarianCancer. Congrats to first author @titosandoval84 and the whole team. #Immunotherapy @WeillCornell @WCM_OBGYN 👇https://t.co/p7vqTw3liN

[Samuel Bakhoum @Samuel_Bakhoum]

Our second of a pair of reviews on how
#Chromosomal_instability #CIN drives #cancer progression is out in ⁦@NatureRevGenet⁩ Reviews led by the talented ⁦@chenxuelan621⁩ ⁦@itsalyourpal⁩ ⁦@JunLi_916⁩ ⁦@melodyDiBona⁩ https://t.co/2aEYWlyEOi

[Samuel Bakhoum @Samuel_Bakhoum]

Our first of a pair of reviews on #Chromosomal_Instability is out in ⁦@NatRevClinOncol⁩ on targeting CIN in patients with #cancer written with the amazing ⁦@RawiDuaa⁩ ⁦@EmanueleLettera⁩ ⁦@JunLi_916⁩ ⁦@melodyDiBona⁩ https://t.co/tywGccHI1X