LauraPasin

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

We've just presented and published a multicenter RCT at #CCR23 and in @JAMA_current!

Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial!

🔗 https://t.co/MEAGJNM2ga

This 🧵 will explain the study in detail /11

#FOAMcc

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

B1/3

NEW ANTIBIOTIC QUIZ

Does the regimen of #meropenem administration (continuous vs intermittent) influence survival in ICU patients with #sepsis or #septicshock?

Stay tuned for #MERCYtrial

@DrToddLee @nickmmark @iceman_ex @CritCareReviews @iamyourgasman @FOAMecmo #FOAMcc

[Giovanni Landoni, MD @giovannilandoni]

@SRAnesthesiaICU @DrToddLee @nickmmark @iceman_ex @msiuba vote and retweet above

how do you administer meropenem?

@DrMCecconi
@ProfMBassetti
@MGrecoMD
@fabiodoc64
@KatiaDonadello
@Area_Critica_
@f_g_sanfilippo
@ECMOdaily
@KhannaAshishCCM
@pwierusz
@abd_jabbar
@jiapenghuang
@germ_red
@ECMOprincess
@FOAMecmo
@DrECMO
@MarcVives13

[Dr.Mohamed El Tahan @tahan_dr]

1-4
Our updated meta-analysis confirmed that low #tidalvolume during #onelungventilation 🔼 P/F ratio, 🔽 PPCs and 🔽 arrhythmias, but 🔼 PaCO2 & no effect on hospital stay
https://t.co/9pWncg5dlv @JCVAonline @SCVA1997 @scahq @EACTAIC @Laura_Pasin @giovannilandoni @gelysamara

[Society of Critical Care Anesthesiologists @SOCCA_CritCare]

In this meta-analysis by Covello, @Laura_Pasin, @giovannilandoni, and others in @NEJMEvidence, steroids were associated with increased mortality when administered to COVID-19 patients not requiring oxygen. #steroids #COVID19

https://t.co/FLZwhYH7Jf

[Giovanni Landoni, MD @giovannilandoni]

A nice @NEJMEvidence editorial on our article on mortality increase when using #glucorticoids in #covid19 who are not receiving #oxygen
https://t.co/QOWGc7xRdP

“...under some circumstances, randomized controlled trials can become infeasible as evidence accrues (e.g., randomization to a probable harmful exposure), as in the meta-analysis by Covello et al.”

kudos to the authors, especially those who are active on twitter :)

@Laura_Pasin
@SFresilli
@LudhmilaHajjar
@azangrillo
@SRAnesthesiaICU

#medtwitter #Foamed

[NEJM Evidence @NEJMEvidence]

“…our meta-analysis shows that administering glucocorticoids in hospitalized patients with Covid-19 not receiving oxygen is likely associated with worse clinical outcomes.” Full study: https://t.co/Q7R9UAsnyB

#IDTwitter #ARDS #CriticalCare

[Critical Care @Crit_Care]

#CritCare #OpenAccess

#Propofol may reduce survival in perioperative and critically ill patients.

Read the full article: https://t.co/JGvQLWm4qM

@jlvincen @ISICEM #FOAMed #FOAMcc

[Stefano Fresilli @SFresilli]

Our latest manouscript sheds new light on treating hospitalized #COVID19 patients not on oxygen therapy!
According to our study sistemic glucocordicoids are detrimental in this setting. 🚨

Read our findings in NEJM Evidence and help spread the word! 📢 #research #coronavirus🦠

[Alberto Zangrillo @azangrillo]

Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen | NEJM Evidence https://t.co/j9pwXbP75Y

[Alessandro Pruna, MD @alessanro_pruna]

‼️Going deep into the problem

⚠️Is propofol detrimental for survival❓

Comments and reflection on propofol and survival MA with the authors: Me and @YukiKotani5
👉https://t.co/CQ2WICBoWa

@ITACTAtwits meet the authors TODAY 6.00pm
🔗FREE link https://t.co/nSjmpnDDda
#FOAMcc

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

🚫 DON’T use glucocorticoids in oxygen-free #COVID19 pts

Just published @NEJMEvidence

Guidelines are against glucocorticoids in pts not on O2 but effect on survival remains unclear

Our meta-analysis found that glucocorticoids increase mortality

🔗https://t.co/ClNMQzKMV7 1/5

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

Propofol may increase mortality in ICU and perioperative settings🚨

Our new meta-analysis documented statistically significantly higher mortality in the #propofol group than control group

Let's go into depth about this provocative result 🧵/7

🔗https://t.co/sHF2hN9s7l #FOAMcc

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

Top Italian #women working in #ICU #Anesthesia by followers. Who did we forget?
@AnesteTista
@LaCampo4
@mary_el83
@Luna41346966
@chiara_robba
@dr_bearighetti
@SilviaDeRosa11
@ElenaG_Bignami
@MariaVargas1st
@KatiaDonadello
@sofia_rosaria
@BaiardoMartina
@mgcalabroMD
@DormioSara

[Giovanni Landoni, MD @giovannilandoni]

YES! it was 2013 when we @Laura_Pasin @azangrillo published a letter in the @NEJM suggesting that #Glutamine supplementation is detrimental for survival of critically ill patients according to multicenter #RCT
https://t.co/mleCLP1rRz

[Giovanni Landoni, MD @giovannilandoni]

This article had large media coverage in Italy, was poorly interpreted, and has 1 dangerous message

YES
non-steroideal antinflammatory agents are ok for patients at home (minor benefits)

NO!
corticosteroids are dangerous and should not be prescribed at home (increase mortality)

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

LET’S REDUCE TRANSUSION BY 20% WITH #TRANEXAMIC acid #TXA
1/

We helped @PHRIresearch in conducting the #POISE3 #RCT published in the @NEJM and presented #ACC22

also #mortality is reduced by 10% in this @NEJM #RCT on #tranexamic acid. This is probably the most important finding

[LauraPasin @Laura_Pasin]

Proud to join @FrontiersIn Anesthesiology as Associate Editor. With an amazing editorial team, this new journal will help shape the future of anesthesiology. Find out more: https://t.co/37QQvbFLvK

[LauraPasin @Laura_Pasin]

The circus has come to Padua! #StopWarInUkraine #PeaceInUkraine

[San Raffaele Anesthesia and Intensive Care @SRAnesthesiaICU]

🫀ANESTHETIC MYOCARDIAL PROTECTION resurrection?

Dozens of colleagues and studies worldwide found a cardioprotective effect of volatile agents in laboratory, animal and human studies over the last decades.

We re-analyzed our large #MYRIADTrial ➡️ https://t.co/Msz7e1M42m #FOAMcc