We've just presented and published a multicenter RCT at #CCR23 and in @JAMA_current!
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial!
🔗 https://t.co/MEAGJNM2ga
This 🧵 will explain the study in detail /11
#FOAMcc
In this meta-analysis by Covello, @Laura_Pasin, @giovannilandoni, and others in @NEJMEvidence, steroids were associated with increased mortality when administered to COVID-19 patients not requiring oxygen. #steroids#COVID19
https://t.co/FLZwhYH7Jf
A nice @NEJMEvidence editorial on our article on mortality increase when using #glucorticoids in #covid19 who are not receiving #oxygen
https://t.co/QOWGc7xRdP
“...under some circumstances, randomized controlled trials can become infeasible as evidence accrues (e.g., randomization to a probable harmful exposure), as in the meta-analysis by Covello et al.”
kudos to the authors, especially those who are active on twitter :)
@Laura_Pasin@SFresilli@LudhmilaHajjar@azangrillo@SRAnesthesiaICU
#medtwitter #Foamed
“…our meta-analysis shows that administering glucocorticoids in hospitalized patients with Covid-19 not receiving oxygen is likely associated with worse clinical outcomes.” Full study: https://t.co/Q7R9UAsnyB
#IDTwitter#ARDS#CriticalCare
Our latest manouscript sheds new light on treating hospitalized #COVID19 patients not on oxygen therapy!
According to our study sistemic glucocordicoids are detrimental in this setting. 🚨
Read our findings in NEJM Evidence and help spread the word! 📢 #research#coronavirus🦠
‼️Going deep into the problem
⚠️Is propofol detrimental for survival❓
Comments and reflection on propofol and survival MA with the authors: Me and @YukiKotani5
👉https://t.co/CQ2WICBoWa
@ITACTAtwits meet the authors TODAY 6.00pm
🔗FREE link https://t.co/nSjmpnDDda
#FOAMcc
🚫 DON’T use glucocorticoids in oxygen-free #COVID19 pts
Just published @NEJMEvidence
Guidelines are against glucocorticoids in pts not on O2 but effect on survival remains unclear
Our meta-analysis found that glucocorticoids increase mortality
🔗https://t.co/ClNMQzKMV7 1/5
Propofol may increase mortality in ICU and perioperative settings🚨
Our new meta-analysis documented statistically significantly higher mortality in the #propofol group than control group
Let's go into depth about this provocative result 🧵/7
🔗https://t.co/sHF2hN9s7l #FOAMcc
YES! it was 2013 when we @Laura_Pasin@azangrillo published a letter in the @NEJM suggesting that #Glutamine supplementation is detrimental for survival of critically ill patients according to multicenter #RCT
https://t.co/mleCLP1rRz
This article had large media coverage in Italy, was poorly interpreted, and has 1 dangerous message
YES
non-steroideal antinflammatory agents are ok for patients at home (minor benefits)
NO!
corticosteroids are dangerous and should not be prescribed at home (increase mortality)
Proud to join @FrontiersIn Anesthesiology as Associate Editor. With an amazing editorial team, this new journal will help shape the future of anesthesiology. Find out more: https://t.co/37QQvbFLvK
🫀ANESTHETIC MYOCARDIAL PROTECTION resurrection?
Dozens of colleagues and studies worldwide found a cardioprotective effect of volatile agents in laboratory, animal and human studies over the last decades.
We re-analyzed our large #MYRIADTrial ➡️ https://t.co/Msz7e1M42m #FOAMcc