Christiansen

RN+ME

[Christiansen @LeneCch]

In vitro study: IgG from #MECFS and Post-COVID patients can enter endothelial cells, bind to mitochondria, and induce fragmentation linked to impaired cellular function.
#proteomics #immunology
https://t.co/QRZSlGFgKT
(Pic: Professor B. Prusty, Rīga Stradiņš University, Latvia)

[Christiansen @LeneCch]

Research team in Australia:
Genetic factors may drive metabolic dysfunction in #MECFS.
°
#Genetics #Metabolomics
(Pic: Dr. Christopher W. Armstrong, PhD, University of Melbourne)
https://t.co/RMcqjWjFLv

[Christiansen @LeneCch]

Research team finds clear, coordinated protein alterations in cerebrospinal fluid of #MECFS patients, indicating active immune and nervous system dysregulation within the CNS
#Proteomics #Immunology #CSF
(pic: Professor Jonas Bergquist, Uppsala University)
https://t.co/rSNON1KI0o

[Christiansen @LeneCch]

Cohort study from Germany:
3.2% of hospital staff develop #MECFS after SARS-CoV-2 infection
– A clear signal of post-infectious disease development.
https://t.co/KIj08KUYIZ
#Covid19

[Christiansen @LeneCch]

Ny forskning i @CellRepMed:
IgG fra patienter med LongCovid kan overføres til mus og inducere vedvarende smerteoverfølsomhed.
https://t.co/6kffqT6tgm…⁠
#antibodies #autoimmunity #ScienceTwitter

[Jeroen den Dunnen @DrDenDunnen]

Our paper is (finally) out in @CellRepMed: antibodies from #LongCOVID patients transfer symptoms to mice, pointing to a potential causal role for autoimmunity: https://t.co/K3za9wNsH2 @amsterdamumc @UMCUtrecht 1/12

[Christiansen @LeneCch]

Research team from Australia shows reproducible evidence of TRPM3 ion channel dysfunction in #MECFS patients
– confirmed across independent laboratories.
https://t.co/VGbQghxMnx
#NKcells #immunology

[Christiansen @LeneCch]

Ny forskning viser reproducerbar evidens for dysfunktion i TRPM3 ionkanaler hos #MECFS patienter
- bekræftet på tværs af
uafhængige laboratorier:
https://t.co/VGbQghxMnx
#NKcells #immunology #ionchannels

[Christiansen @LeneCch]

Could #MECFS be linked to brain inflammation? New study from Australia suggests it might…
https://t.co/L6pgaW7AGr
#MRI #neuroinflammation #Neuroimaging
***
(Pic: Dr. Qiang Yu, Thompson Institute,
University of the Sunshine Coast

[Christiansen @LeneCch]

The team also found signs of cellular energy dysfunction in patients (changes in AMP/ADP and ATP production), pointing in the same direction as Maureen Hanson’s findings: metabolic dysfunction in the biology of the disease.
(pic: Professor Maureen Hanson, Cornell University).

[Christiansen @LeneCch]

Research team from Norway finds evidence that #MECFS
involves energy dysfunction, immune disturbances, and vascular changes.
#immunology #metabolism
https://t.co/FjyipEFeIf
(pic: Professor Karl Johan Tronstad, Haukeland University)

[Christiansen @LeneCch]

HHV‑6 RNA can be detected directly in tissues not routinely examined;
This 2022 study found herpesvirus HHV‑6 activity in the brains of #MECFS patients
***
https://t.co/auFTaubIdT⁠
#Neuro #virology
(Pic: Professor of science, Bhupesh Prusty, Rīga Stradiņš University, Latvia)

[Christiansen @LeneCch]

Research team from Australia used a powerful 7Tesla and found significant deficits in functional connectivity in brain of LongCovid patients.
(Pic: National Centre for Neuroimmunology and Emerging Diseases, Griffith University).
#hjerne #forskning
https://t.co/8ZqWhz3AoN

[Christiansen @LeneCch]

Elektrofysiologiske eksperimenter viser en signifikant reduktion i TRPM3-funktionen i NK-celler fra personer diagnosticeret med #MECFS sammenlignet med kontrolpersoner.
https://t.co/VGbQghxMnx
#TRPM3 #NKCells #forskning

[Christiansen @LeneCch]

Macro- and microvascular endothelial function reduced in patients with #MECFS.

#EndothelialDysfunction #FMD
https://t.co/UUxRJ4MIBd
(Photo from https://t.co/O2x2rf9Jw8): Dr. Fluge and Dr. Mella, Haukeland University Hospital, Bergen, Norway).

[Christiansen @LeneCch]

Forskning fra Cornell University, USA:
MECFS patienter udviser vedvarende og afvigende ændringer i immun-, energi- og stressrelaterede proteiner, som raske ikke gør.
#proteomics #PEM
https://t.co/0V9pZ9hvIh

[Christiansen @LeneCch]

Ny forskning fra USA: Sammenlignet med kontrolpersoner udviste patienter med MECFS vedvarende dysregulering af immun-, metaboliske og neuromuskulære stiveje. 
(Foto: Professor Maureen Hanson, Cornell University)
https://t.co/ZdekhabYMY

[Christiansen @LeneCch]

Ny forskning fra USA:
Personer med #MECFS får langvarige forstyrrelser i immunforsvar, stofskifte og muskelfunktion efter fysisk aktivitet.
Belastning udløser målbare ændringer i tusindvis af proteiner, som hænger sammen med symptomer og nedsat ydeevne.
https://t.co/K16F7moO4t

[Christiansen @LeneCch]

University of Edinburghs Institut for Genetik og Kræft har fundet en genetisk forbindelse i DNA hos personer med ME/CFS sammenlignet med den generelle befolkning.
(Pic: Professor Chris Ponting, University of Edinburgh)
https://t.co/TuWsb3w4tb

[Christiansen @LeneCch]

Ny britisk forskning:
Your genes contribute to your chances of developing ME/CFS.
https://t.co/TuWsb3w4tb

[Christiansen @LeneCch]

Endnu et godt resultat fra biomedinsk ME/CFS forskning:
Biomarkører, der kan testes i blod fra patienter er på vej.
#mecfs #research
https://t.co/tjQvMHrSxZ