Charles Lépine, MD

Pathologist 🇨🇵 Fellowship in #ENTpath and #BSTpath 2021-2023 at @CHUnantes 🔬 PhD student ⚗️Co-community manager of @Annpathol.
#Pathology #AI

[Scott Kilpatrick, MD @ScottBikeethan]

As many of you now may be aware, Dr. Chris Fletcher recently passed away. His contributions to the field of ST pathology (and my career) are immeasurable. Interestingly, once I decided in 1993 to develop expertise in #BSTpath, my question was where (or with whom) would I train?

[Nature Rev Immunol @NatRevImmunol]

CD28 co-stimulation: novel insights and applications in cancer immunotherapy https://t.co/Qyo2YMCvig

[Dr. Iván R. González @Dr_Ivanoncologo]

Identification 🤓of Resistance Biomarkers to HER2 Inhibitors: Advances and Challenges in HER2+ Breast Cancer

🔴Therapeutic advances: HER2 inhibitors have significantly improved the treatment of HER2+ breast cancer.
🟢Persistent challenge: Resistance to these drugs remains a critical issue.
🔵Key biomarkers identified: Mutations in the ERBB2 gene, activation of alternative signaling pathways, expression of estrogen receptors, and alterations in regulatory protein levels have been found.
🟡New explorations: More effective regimens and promising combination therapies are being investigated.
🌟This review highlights current HER2-targeted therapies, analyzes predictive biomarkers of drug resistance, and presents emerging therapies, especially combination treatments, aimed at overcoming resistance in the context of HER2+ breast cancer. @OncoAlert @BCTrials @BCTrials @DraMartinezLago @Dra_Kleine
https://t.co/zd0LDEQevP

[Plume @plumenetwork]

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[Caldera @Calderaxyz]

We're excited to announce our $15M Series A led by @foundersfund to build the Metalayer, the end game for Ethereum rollups 🌋

This round brings our total funding to $25M and will help us advance our goal of making Ethereum go web-scale.

[Charlie Herndon @DrCycloPath]

❌GCT of bone: adults, oval mononuclear cells (not spindled like NOF), giant cell nuclei ~ mononuclear cell nuclei that are (+) H3.3 G34W
❌ Fibrous dysplasia: well-demarcated ground glass lesion; irregular trabeculae in background of bland spindle cells
✅Non-ossifying fibroma: kids, metadiaphyseal lobulated lesion with sclerotic rim; bland storiforming fibroblasts, interspersed osteoclast-like multinucleated giant cells
#PediPath #BSTPath #PathTwitter #Pathology

[Jerad Gardner, MD @JMGardnerMD]

Bone lesion. Your diagnosis? Answer here: https://t.co/d4xdaG62p2 @smlungpathguy @Radiopaedia #BSTpath #radpathmatch #radiology #sarcoma #pathologists #pathology #pathTwitter

[Tim Bracey @drtimbracey]

Clear cell metaplasia in a sigmoid polyp from my colleague @edinpath. Resembles secretory endometrium and perhaps Sertoli cells! No clinical importance but pretty! Nice review by Dabir, van der Post & Nagtegaal. Histopathology, 2021. 78: 348-357 #GIpath #Pathologists @pathkids

[Plume @plumenetwork]

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[MrBeast @MrBeast]

I’m gonna give 10 random people that repost this and follow me $25,000 for fun (the $250,000 my X video made)

I’ll pick the winners in 72 hours

[Société Française de Cytologie Clinique @SFCCFrance]

Excellent symposium SFCC/SFP glandes salivaires Carrefour Pathologie 2023 #Milan2 classification OMS Apport de la bio mol
Charles Lépine Valérie Costes-Martineau Claude Bigorgne Emmanuelle Uro-Coste 👏🏻👍🏻

[Annales de Pathologie @Annpathol]

🔬 La Société Française de Pathologie et les Annales de Pathologie s'associent pour l'édition 2023 du concours photo 📸
⏳ Vous avez jusqu'au 1e octobre pour y participer!
👉 Toutes les infos sont ici https://t.co/FwSu2OzjNM
#pathart #pathology #francophonepath
@SFPathol

[Dr. Luca @atman_ci]

And finally Case N°3, a classic in #BSTPath #DermPath with this I wish you a great WeekEnd! @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke @Venkateshgilly2 #pathology #PathTwitter

[Dr. Luca @atman_ci]

Let's go to case N°2, here the IHC to guess is expressed only focally @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke @Venkateshgilly2 @DrBonita16 #pathology #PathTwitter #BSTPath

[Dr. Luca @atman_ci]

Three different #BSTPath entities and the same IHC marker, are you able to tell me which diagnoses and which shared IHC? @PoloniaAntonio @DrBMcGinn @NeoCrazee @sumeyra_md @caseypschukow @LepinePathol @rehdam @ZKrikic @nusrat_xahra @Kashifhazim @goziemnweke #PathTwitter
Case N°1:

[Dr. Luca @atman_ci]

A special #BSTPath hat trick, same IHC but different diagnoses, N°1: old F, trunk dermal lesion, your thoughts? @PoloniaAntonio @SumantaDas_7 @sumeyra_md @NeoCrazee @rehdam @DrGeeONE @seyma_buyucek @LepinePathol @LuizMiguelN @DrNishatAfroz2 @Greg_Charville @DrBMcGinn #PathTwitter

[Ilan Weinreb 🇮🇱🇨🇦 אילן וינרב @WeinrebIlan]

Twitter me this…

🔹Large sinonasal mass.

🔹H&Es attached.

[Charles Lépine, MD @LepinePathol]

Mesmerizing urate crystals river 😲❤️

[Dr. Luca @atman_ci]

Two 'hot' #BSTPath cases to warm up your weekend! N°1: 45yF, thigh mass, deep located. Your differentials? Any IHCs? @PoloniaAntonio @caseypschukow @SumantaDas_7 @LoboAnandi @Romanow_MD @shahidi_hossein @DrGeeONE @NeoCrazee @sumeyra_md @DrNishatAfroz2 #PathTwitter #pathresidents

[Cecile Badoual @CecileBadoualMD]

Quand une interne en gynécologie fait des interviews 🦸🏻‍♀️ bravo Yousrah ☀️ et merci de mettre en lumière le métier d’anatomo-pathologie https://t.co/IWeBerktQB @VerkarreVirgin2 @A_Morini_MD @LepinePathol @ChloeBrdn