Li Ma, PhD

Professor @MDAndersonNews studying #metastasis & #immune response. @PKU1898 | @WeillCornellGS-@MSKCancerCenter | @WhiteheadInst alum. Views=own

[Li Ma, PhD @LiMaCancerLab]

Our new paper in @ScienceTM: In vivo #CRISPR activation screen identifies acyl-CoA binding protein as a driver of #bone #metastasis. Super excited by this discovery! @ACS_Research @AmericanCancer @MDAndersonNews

https://t.co/ioFPgWvpjV

[Science Translational Medicine @ScienceTM]

A clinical study reveals why vaccines for meningococcus can partially protect against gonorrhea, CRISPR screens reveal a new treatment target in bone metastasis, and more in the new issue of #ScienceTranslationalMedicine. https://t.co/fbe16c7XiJ

[Li Ma, PhD @LiMaCancerLab]

@QingZhangLab @NatureComms Congrats Qing and team 🍾

[Science Translational Medicine @ScienceTM]

Leveraging #CRISPR activation screens, researchers identify the lipid metabolism protein ACBP as a key driver of bone metastasis, and show etomoxir or a ferroptosis inducer can prevent bone metastasis in mice. @LiMaCancerLab @MDAndersonNews https://t.co/k3lTJZn9fo

[Li Ma, PhD @LiMaCancerLab]

@Debeblab @ACKoongMDPhD @ScienceTM @MDAndersonNews @DraettaG @CarinHagberg Thank you, Bisrat!

[Li Ma, PhD @LiMaCancerLab]

🦴Our @ScienceTM study discovered ACBP as a metabolic driver of #BONE #metastasis.
🔬 Blocking fatty acid oxidation or inducing ferroptosis shuts down bone metastasis in vivo.
📰 @MDAndersonNews highlight:
https://t.co/mIlcHs8XWx

@ACKoongMDPhD @DraettaG @CarinHagberg

[Li Ma, PhD @LiMaCancerLab]

@Dr_Di_Zhao @ScienceTM @ACS_Research @AmericanCancer @MDAndersonNews Thank you, Di! It’s great our papers are published in the same week 😸

[Li Ma, PhD @LiMaCancerLab]

Our new paper in @ScienceTM: In vivo #CRISPR activation screen identifies acyl-CoA binding protein as a driver of #bone #metastasis. Super excited by this discovery! @ACS_Research @AmericanCancer @MDAndersonNews

https://t.co/ioFPgWvpjV

[Science Translational Medicine @ScienceTM]

A clinical study reveals why vaccines for meningococcus can partially protect against gonorrhea, CRISPR screens reveal a new treatment target in bone metastasis, and more in the new issue of #ScienceTranslationalMedicine. https://t.co/fbe16c7XiJ

[Li Ma, PhD @LiMaCancerLab]

@LilingWanLab @ScienceTM @MDAndersonNews @ACKoongMDPhD @DraettaG @CarinHagberg Thank you, Liling!

[Li Ma, PhD @LiMaCancerLab]

Grateful to my lab and collaborators for this super exciting milestone!

[Li Ma, PhD @LiMaCancerLab]

Bone metastasis remains a major clinical challenge. By identifying ACBP as a metabolic driver of this process and demonstrating the efficacy of targeting lipid metabolism in preclinical models, our work opens new therapeutic avenues for halting bone metastasis.

[Li Ma, PhD @LiMaCancerLab]

@QingZhangLab @ScienceTM @ACS_Research @AmericanCancer @MDAndersonNews Thank you, Qing!

[Li Ma, PhD @LiMaCancerLab]

@LiuCluster @FangjiaTong @ACS_Research @AmericanCancer @LurieCancer @NorthwesternU Congratulations, Huiping and team!

[Li Ma, PhD @LiMaCancerLab]

@Dr_Di_Zhao @NatureComms Congratulations! You rock!

[Li Ma, PhD @LiMaCancerLab]

Hiring Postdoctoral Fellows for Cancer Metastasis & Immunotherapy research in my lab at MD Anderson! #PostdocJobs #CancerResearch @MDAndersonNews Apply: https://t.co/vbMZXI7tFP

[Ivan Zanoni @Lo_Zanzi]

#EveryCellIsAnImmuneCell! Deng @LiMaCancerLab &co show @NatMetabolism that during liver damage, LIFR drives production of CXCL1 by hepatocytes to recruit bone marrow neutrophils. LIFR also increases cholesterol secretion that makes neutrophils reparative! https://t.co/RUEQRawypu

[Li Ma, PhD @LiMaCancerLab]

@RuggeroDavide @NatMetabolism @Zhu_Lab Thanks Davide! Just read your new Nature paper. Still remember the day your first paper on eIF4E got accepted by Nat. Med. After 20 years, it is now in the limelight of the cancer metabolism field.

[Li Ma, PhD @LiMaCancerLab]

A bittersweet day to move in my freshman to college, and report in @NatMetabolism the liver tumor suppressor LIFR orchestrates cholesterol-driven bidirectional hepatocyte-neutrophil crosstalk to facilitate #liver injury repair & #regeneration. Thx @Zhu_Lab
https://t.co/Wm2KDuIr5k

[Li Ma, PhD @LiMaCancerLab]

17-Kudos to the first author @Yalan_Deng and my entire team for their hard work and continued inspiration. Huge thanks to our collaborators, @Zhu_Lab, Michael Curran, and Chunru Lin, for sharing their resources and outstanding expertise.

[Li Ma, PhD @LiMaCancerLab]

1-Tweetorial for our @NatMetabolism paper on #metabolic and #immune regulation of tissue repair and #regeneration: https://t.co/I1k3MObesp. In 2012, my lab at @MDAndersonNews reported that the cytokine receptor LIFR is a breast cancer #metastasis suppressor (Nat. Med. 2012).

[Li Ma, PhD @LiMaCancerLab]

16-Here, our findings reveal the mechanisms underlying injury-induced efflux of bone marrow neutrophils to the circulation and damaged liver, and uncover how reparative neutrophils signal to hepatocytes to proliferate in response to liver injury.