Lopchuk Lab

Synthetic organic chemistry research @ Moffitt Cancer Center and USF.

[Lopchuk Lab @LopchukLab]

Today in @NatureComms we report the rapid, stereocontrolled synthesis of sulfinamides, sulfonamidamides, and sulfoximines by leveraging a mild strain-release driven amine exchange with t-BuSF, our lab's recently reported S(VI) reagent. https://t.co/2gTNFF6AXZ

[Lopchuk Lab @LopchukLab]

Congratulations to Daria and Vishala!
https://t.co/jdoz2b4ouq

[Lopchuk Lab @LopchukLab]

Today in ChemRxiv, we report the C-H amination of unactivated alkanes and aldehydes with diazirines via photocatalysis. This method provides our first approach to acyl diaziridines, which are readily converted to amides, hydrazides, acyl hydrazones and heterocycles.

[Moffitt Cancer Center @MoffittNews]

Today we’re celebrating the launch of @AccelerOnc, the first U.S. venture studio focused solely on oncology innovation and founded by Moffitt. By merging data, expertise and urgency, we’re driving bold ideas forward to prevent and cure cancer.
#InnovationToImpact

[Moffitt Cancer Center @MoffittNews]

Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2025

Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors:
• Cancer Biology
• Cancer Chemical Biology
• Cancer Immunology & Immunotherapy
• Integrated Mathematical Oncology

Why Moffitt?
• Access to top research facilities
• Collaborate with world-leading scientists
• Hands-on experience in cutting-edge research
• Supportive environment for innovation
• Unmatched translational environment, turning discoveries into cures

Start your journey to make a difference in cancer care and innovation.

Learn more and apply now: https://t.co/qc33S8WvUe

[Lopchuk Lab @LopchukLab]

The full job postings and application instructions are found below. The applications will be reviewed on a rolling basis until the positions are filled.

https://t.co/7c1grpTTIe

https://t.co/cGWnlYTI84

[Lopchuk Lab @LopchukLab]

We have openings for two postdoc positions in synthetic organic chemistry. The first position focuses on the development of new chemical methods and reagents (with targeted synthesis applications) as well as a structure-based drug discovery program in oncology.

[Lopchuk Lab @LopchukLab]

The second position focuses on the development of new chemistry for selective covalent inhibition. This encompasses method development, targeted synthesis, and translational collaborations.

Applications are accepted by email at justin.lopchuk [at] moffitt [dot] org.

[Lopchuk Lab @LopchukLab]

An offshoot of our S(VI) work, it allows for the rapid preparation of funtionalized phosphonates onto heterocycles. No transition metals or photochemistry required.

[Lopchuk Lab @LopchukLab]

With the renewed interest in chemical methods around phosphonates, I thought it might be worth reposting a method we reported several years ago (especially since it seems people in the field have overlooked it...).

https://t.co/PdlpgkNHaW

[Lopchuk Lab @LopchukLab]

Deadline approaching to apply to Moffitt’s Cancer Chemical Biology PhD program! Come join our growing cohort of graduate students pursuing research in synthetic organic chemistry, medicinal chemistry, chemical proteomics, chemical biology, structural biology and drug discovery.

[Moffitt Cancer Center @MoffittNews]

Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2024

Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors:

• Cancer Biology
• Cancer Chemical Biology
• Cancer Immunology & Immunotherapy
• Integrated Mathematical Oncology

🧬 Why Moffitt?
• Access to top research facilities
• Collaborate with leading scientists
• Hands-on experience in cutting-edge research
• Supportive environment for innovation

🔗 Learn more and apply: https://t.co/qc33S8WvUe

[Lopchuk Lab @LopchukLab]

Moffitt Researchers Develop New Chemical Method to Enhance Drug Discovery | Moffitt https://t.co/g1mnRMQeeB

[Pat Carragher @PatCarragher]

🧪NEWS from @LopchukLab

Moffitt Researchers Develop New Chemical Method to Enhance Drug Discovery

https://t.co/3CVwsBlDgP

[Lopchuk Lab @LopchukLab]

Excellent work done by @aparesh_2, @ZacharyShultz6, Alexandra and Eve. Much more to come in this area from us soon.

[Lopchuk Lab @LopchukLab]

Today in @NatureComms we report the rapid, stereocontrolled synthesis of sulfinamides, sulfonamidamides, and sulfoximines by leveraging a mild strain-release driven amine exchange with t-BuSF, our lab's recently reported S(VI) reagent. https://t.co/2gTNFF6AXZ

[Lopchuk Lab @LopchukLab]

We also demonstrate a combinatorial workflow optimized for the typical 8 hour workday of a single medicinal chemist. 44 unique, highly functionalized sulfonimidoyl ureas were generated from a common precursor over 4 transformations (>50% yields, 10-60 mg of final products).

[Dr. Patrick Hwu @PatrickHwuMD]

Congrats to @LopchukLab and colleagues for their innovative scalable synthesis of withanolides, compounds in plants that inhibit #cancer cell growth. Their groundbreaking work was recently published in @ScienceAdvances. https://t.co/NuNArTodjg

[Moffitt Cancer Center @MoffittNews]

A new Moffitt publication from @LopchukLab shares an organic synthesis breakthrough: cobalt-catalyzed regioselective hydroamination of unactivated olefins using diazirines.

This versatile method produces diaziridines easily converted to primary amines, hydrazines and heterocycles. It has significant implications for medicinal chemistry and cancer drug development. 

👉 Read here: https://t.co/9ziG4nAaBf

[Lopchuk Lab @LopchukLab]

A novel synthesis of our bis-15N diazirine enables the isotopic labeling of any of our past and present diazirine aminations without the need for redesign of the synthetic routes. Congrats to Qingyu, @Preeti_0609, and @khaliliachanel.

[Lopchuk Lab @LopchukLab]

Today in @NatureComms we report the regioselective hydroamination of unactivated olefins with diazirines. Over 50 examples highlight excellent functional group tolerance and permit the rapid synthesis of alkyl amines, hydrazines, and heterocycles. https://t.co/hoTfBUBnCL

[Lopchuk Lab @LopchukLab]

The scope includes the late-stage amination of 14 terpene natural products and [1.1.1]propellane, while the synthetic applications demonstrate the target-oriented synthesis of numerous pharmaceuticals such as mecamylamine, neramexane, and a splicing modulator.