Lotus Lum

Yale Immunobiology PhD student. UC Berkeley '19.
Studying tumor associated macrophages
but also i like to climb

[Jennifer Guerriero, PhD @JennGuerriero]

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.

[Melissa Reeves @melissaqreeves]

Our story made the cover of @JExpMed! So excited to share our work showing how tumor cells profoundly shape their local immune microenvironment @MihoTanakaMT

[Waggoner Lab @LabWaggoner]

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis @CellCellPress
https://t.co/H73S8ylbHI

[Ming "Tommy" Tang @tangming2005]

9 tools for interactive exploring single-cell RNAseq data 🧵 👇

[Science Immunology @SciImmunology]

In a recent Science #Immunology Review, researchers discuss ways in which genetic abnormalities enable #cancer cells to evade #antitumor immunity and resist treatment. https://t.co/CrW5eEAywh #DayOfImmunology

[Itai Yanai @ItaiYanai]

Have changes in science over the past 50 years reduced the chances of trainees experiencing the joy of discovery?

[Itai Yanai @ItaiYanai]

Is there anything more fun than starting your talk with a walk-up song?! Thank you to the brilliant 3rd year Immunobiology PhD students at Yale who organized the '12th Yale Immunobiology Student Symposium' today.

[Lotus Lum @LotusLumphocyte]

@ItaiYanai Thank you so much for bringing such good energy to the symposium!! It was such an honor to have you!!

[Science Immunology @SciImmunology]

A new Review suggests that genomic changes in #cancer cells can shape antitumor immune cells and facilitate #immunogenomic cancer evolution, which could inform future strategies for precision medicine.

Learn more in Science #Immunology: https://t.co/CrW5eEAywh

[Waggoner Lab @LabWaggoner]

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response @JExpMed
https://t.co/37vDsAYBiH

[Journal of Experimental Medicine @JExpMed]

How does tumor heterogeneity impair the immune response to cancer? @MihoTanakaMT, @melissaqreeves @UUtah et al. show tumor cells shape their microenvironment on a highly local level, using CX3CL1 to create spatial pockets of immunosuppression. https://t.co/5ihRk2FMEY

[Santosh Chauhan @Chauhanlab_ILS]

Announcing, one of a unique conference. #CellDeath, #Innateimmunity, and #Autophagy. Top speakers, top Science. website -open soon- Please retweet. @EMBO @India_Alliance @ccmb_csir @CSIR_IND @jkagan1 @dixitvishva @vpderetic @v_hornung @ThiruKanneganti @ClareBryant13 @iDikic2

[Jun Kim @Jun_kiim]

Just published in Nature (Fed 2025), Tyler Miller, MD, PhD et al. have made a major conceptual leap in characterizing glioma-associated myeloid cells--not by their lineage but by their functional states dictated by local microenvironmental cues (Bradley Bernstein lab at Dana-Farber Cancer Institute).

In this study, Miller et al. pinpoint four key "activity programs" in glioma-associated myeloid cells: systemic inflammatory, microglial inflammatory, complement immunosuppressive, and scavenger immunosuppressive. Remarkably, any of the myeloid subsets (microglia, macrophages, monocytes, and dendritic cells) can adopt these programs in response to local cues like hypoxia, IL-1B, TGFb, or steroids.

Notably, the "scavenger immunosuppressive" programs correlate strongly with worse clinical outcomes, and ex vivo reprogramming data reveal transcriptional regulators (AP-1, p300/CBP) with the potential to convert an immunosuppressive environment into an inflammatory, T cell-supportive one.

[Lena Wirth @lena__wirth]

1/Excited to share our latest work published in @CD_AACR. Led with #MiyaHugaboom, #KellyStreet, we show that the presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in #RCC patients: https://t.co/Apw81TaY0Q

[Waggoner Lab @LabWaggoner]

Innate immune memory is stimulus specific
@arjunrajlab @O_Farrell_Aoife
https://t.co/fHnP9NUaCf

[Maria Robles @RBioceutics]

Evil macrophages that promote #cancer.

“Unleash the DC”

$nwbo

https://t.co/33N0oGbYXq

[Waggoner Lab @LabWaggoner]

Gasdermin D pore-laden pyroptotic vesicles transplant these pores on neighboring cell surfaces and propagate cell death to bystander cells @CellCellPress @RathinamVA
https://t.co/MR0s9dg2i5

[Immunity @ImmunityCP]

Online now: Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion https://t.co/fnnRUAvbBg

[Cell @CellCellPress]

In the latest issue! Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer https://t.co/J2AwhDcisj

[Cancer Cell @Cancer_Cell]

Unraveling the tumor-initiating cells in hepatocellular carcinoma https://t.co/bWGLr5DhSI