Our paper is out, and we are on top headlines!
https://t.co/WZxwajAWHR
Thank you to everyone that helped.
We found that cells with #invadopodia can lead cells without invadopodia in cooperative #invasion, and enable their #metastasis.
A little thread.
Finally, co-injection of cells in mice demonstrated that cells without invadopodia can invade and metastasize via cooperation with cells that assemble invadopodia.
Full data here: https://t.co/mO61rMyD4j
When we mixed the 2 cell lines, we found that cell sorted from each other and then performed cooperative invasion, with 4T1 cells being the leaders. Cell sorting was not due to cell-cell adhesions but to differential persistence and differential adhesion to the ECM.