Here we go! Excited to share our latest collaborative work with @MichaelMShen and @califano_lab.
We uncovered that NSD2-catalyzed H3K36me2, a histone mark dearest to our lab, is critical for lineage plasticity and resistance to anti-androgen in prostate cancer.
Further, recent work from Gozani, Mazur, Majewski and Jaremko labs demonstrates therapeutic benefit of NSD2 inhibitor in preclinical models of lung and pancreatic cancers, suggesting a broad role of H3K36me2 in cancer chromatin plasticity: https://t.co/IDFTCpY8bV
While there is still a lot to learn about the underlying mechanism, these findings suggest the therapeutic potential of combining NSD2 inhibitor with AR inhibitor in treating aggressive prostate tumors. A clinical study is already ongoing: https://t.co/dFnVCOIPbb
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
https://t.co/ZckwqVoy4M
Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC@MDC_Berlin).
Please share 🙏
#epigenetics
Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome.
https://t.co/wRBWwxFBif
Please Repost-
Excited to be recruiting @CeiFccc@FoxChaseCancer#epigenetic#faculty to continue building our energetic, interactive, supportive #collegial environment
Our goal- Basic Discovery & help translate to positively impact patients
Apply here-
https://t.co/UwItg5JvBN
Here we go - our preprint on the interplay between DNMT3A and polycomb H2AK119Ub mark is published. We believe these findings offer a potential mechanism driving DNA hypermethylation in cancer. Pls see tweetorial for more details. https://t.co/VdJieE9k6P
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson https://t.co/x31H5e2IeU
Lastly, shoutout to two other papers that characterize the interaction between DNMT3A and H2AK119Ub nucleosome.
https://t.co/O7NaCPGmVK by Jikui Song and Greg Wang groups.
https://t.co/AoXYF5TUnA by @mdrwilson group.