Lu Lab_Columbia

Chromatin & Cancer Biologists at Columbia university

[Lu Lab_Columbia @LuLaboratory]

Please spread the word and register. Great event for sharing science and building collaboration for NYC epigenetic labs!

[nyc chromatin club @nycchromatin]

Registration - NYC Chromatin Club - July 21, 2026 - https://t.co/xG3eRqciKk

[Lu Lab_Columbia @LuLaboratory]

@bsabari @MichaelMShen @califano_lab Thanks Ben!

[Lu Lab_Columbia @LuLaboratory]

Here we go! Excited to share our latest collaborative work with @MichaelMShen and @califano_lab.

We uncovered that NSD2-catalyzed H3K36me2, a histone mark dearest to our lab, is critical for lineage plasticity and resistance to anti-androgen in prostate cancer.

[nature @Nature]

Nature research paper: NSD2 targeting reverses plasticity and drug resistance in prostate cancer

https://t.co/Jbmh0mYAOZ

[Lu Lab_Columbia @LuLaboratory]

Further, recent work from Gozani, Mazur, Majewski and Jaremko labs demonstrates therapeutic benefit of NSD2 inhibitor in preclinical models of lung and pancreatic cancers, suggesting a broad role of H3K36me2 in cancer chromatin plasticity: https://t.co/IDFTCpY8bV

[Lu Lab_Columbia @LuLaboratory]

While there is still a lot to learn about the underlying mechanism, these findings suggest the therapeutic potential of combining NSD2 inhibitor with AR inhibitor in treating aggressive prostate tumors. A clinical study is already ongoing: https://t.co/dFnVCOIPbb

[Lu Lab_Columbia @LuLaboratory]

@jdlicht @VAInstitute Congrats Jon! What a great news.

[nyc chromatin club @nycchromatin]

Symposium Registration Deadline Friday! - NYC Chromatin Club - https://t.co/e0QxifI1ih

[nyc chromatin club @nycchromatin]

Registration - NYC Chromatin Club - July 15, 2025 - https://t.co/04pIU6av6X

[Duncan Sproul @sproul_lab]

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
https://t.co/ZckwqVoy4M
Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC @MDC_Berlin).
Please share 🙏
#epigenetics

[Lu Lab_Columbia @LuLaboratory]

@black_pine_tree Awesome - congrats Luke and Tom!

[Lu Lab_Columbia @LuLaboratory]

@gamzeandgursoy @NAR_Open Congrats Gamze, Carlos and Narjis!

[Lu Lab_Columbia @LuLaboratory]

Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!

[Molecular Cell @MolecularCell]

In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome.
https://t.co/wRBWwxFBif

[Lu Lab_Columbia @LuLaboratory]

Check out this important work - congrats to KJ, Victoria and the team!

[Whetstine Lab @WhetstineLab]

Please Repost-
Excited to be recruiting @CeiFccc @FoxChaseCancer #epigenetic #faculty to continue building our energetic, interactive, supportive #collegial environment

Our goal- Basic Discovery & help translate to positively impact patients
Apply here-
https://t.co/UwItg5JvBN

[Lu Lab_Columbia @LuLaboratory]

@XR_Lab Wow! Congrats and all the best with the move!

[Lu Lab_Columbia @LuLaboratory]

@Goodell_Lab @KristjanGretars Thank you Peggy!

[Lu Lab_Columbia @LuLaboratory]

Here we go - our preprint on the interplay between DNMT3A and polycomb H2AK119Ub mark is published. We believe these findings offer a potential mechanism driving DNA hypermethylation in cancer. Pls see tweetorial for more details. https://t.co/VdJieE9k6P

[Kristjan Gretarsson @KristjanGretars]

Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson https://t.co/x31H5e2IeU

[Lu Lab_Columbia @LuLaboratory]

@sproul_lab Thank you and we really like your DNMT3B study!

[Lu Lab_Columbia @LuLaboratory]

@joshuagruber Thanks Josh! Hope all is well!

[Lu Lab_Columbia @LuLaboratory]

@maxvcg @KristjanGretars Thank you Maxim!

[Lu Lab_Columbia @LuLaboratory]

Lastly, shoutout to two other papers that characterize the interaction between DNMT3A and H2AK119Ub nucleosome.
https://t.co/O7NaCPGmVK  by Jikui Song and Greg Wang groups.
https://t.co/AoXYF5TUnA  by @mdrwilson group.

[Lu Lab_Columbia @LuLaboratory]

Congrats again to @KristjanGretars @Xagbomson Susan Gloor, Dan Weinberg, @KJArmache @GCloner @epicypher and everyone involved! Thanks to the reviewers and editor @ScienceAdvances for improving our manuscript.