Makaía Papasergi-Scott

G protein signaling. GPCRs. Protein structure & Biochemistry. CryoEM.

[ASPET @ASPET]

Send in your research to this special collection covering key areas of GPCR research. The collection will include original research articles and a limited number of commentaries and consideration for minireviews: https://t.co/EXUsmdWfbD

[Ben Myers Lab @Myers_lab]

Now online in @NatureSMB - We combine AlphaFold, structural, and biochemical approaches to show that SMO directly inhibits PKA via a pseudosubstrate mechanism—revealing a new mode of #GPCR signal transduction in the #Hedgehog pathway. Big thanks to everyone who contributed!

[Tall G protein Lab @lab_tall]

Self-cleavage-dependent and -independent functions of Adgrg1/Gpr56 in mice | PNAS https://t.co/WEFBdIxxyS

[EMDB - EMPIAR @EBI @EMDB_EMPIAR]

🚨Job opening 🚨: In 2020, cumulatively 10,000 #cryoEM structures had been resolved. By 2025, 10,000 #cryoEM structures were determined within a single year. Join the international effort making all this data available. OneDep biocurator on the EMDB team: https://t.co/c5aTSYCPlV

[ASPET @ASPET]

The deadline has been extended to August 31 for Molecular Pharmacology's upcoming special collection, which celebrates the world-leading research showcased by attendees of the 5th Transatlantic ECI GPCR Symposium. Learn more: https://t.co/zSSw89R0mD

[Science Signaling @scisignal]

The new issue of #ScienceSignaling has arrived!

Research in mice shows how microglia can trigger depressive-like behaviors linked to neuroinflammation, in vitro work reveals that adhesion GPCRs aren’t activated by corticosteroids, and more. https://t.co/9wUk8fuYtu

[Science Signaling @scisignal]

A mechanistic analysis of adhesion #GPCRs reveals that peptide mimics, but not the corticosteroid beclomethasone, can activate signaling downstream of the GPCR GPR97/ADGRG3 and trigger neutrophil shape changes and migration. @UMPharmacology @lab_tall https://t.co/3DmajFziMK

[ECI GPCR symposium @cool7TMs]

Register today!
We're excited to see your GPCR research 😄
Keynote lectures will be announced soon, so stay tuned! 👀

[Michael J. Robertson @BiophysicsGuy]

Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving Gi activation and how its modulated by different ligands!
https://t.co/2E5cQPf6Xb

[Cornelius Gati @CorneliusGati]

Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! https://t.co/asIcSp9gF6

[Cesare Orlandi @orlandi_cesare]

Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts.
https://t.co/zJ5P5Fo0vS

[Reto Fiolka @RetoPaul]

Maybe the most amazing microscope paper of the year just dropped: Live 4pi-SIM (a.k.a I5S*):
https://t.co/RJale5ulmK

Having worked with Mats Gustafsson, I can attest that this is both extremely hard, but also extremely cool!

Kudos to the authors!

*https://t.co/ysoGgXIlF7

[Dirk H. Trauner @DirkTrauner]

Introducing a new class of potent opioid analgesics that remain in the periphery (hence no respiratory depression) and can be locally activated with light (hence no constipation). As efficacy switches, they also provide insight into how opioids can switch from weak to strong agonists! Great collab with Seva Katritch, Cornelius Gati, and Josh Levitz.

https://t.co/G4MpZPr1NZ

[Zhixing Chen @ZhixingChen2]

How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling.
https://t.co/rQyfAClwm1
Special thanks to Alice Ting for discussions!

[Membrane Protein PDB @MemProtPDB]

Conformational plasticity of human acid-sensing ion channel 1a | bioRxiv

https://t.co/s2h2138I1O

[Dr Chinna Devarapu @ChinnaDevarapu]

1/6 🧵 I'm building what might be the smallest
#opensource #spectrometer with an easy to use UI! I call it a pocket spectrometer. Combining #M5StickC(~$20) with #AS7341 sensor (~$16). My goal? A complete spectrometer that is barely larger than a sample cuvette itself.

[IsomLab @danIsomLab]

I would appreciate community guidance on building out research computing resources from scratch. Rather than building/maintaining compute clusters, what are the best cloud-based, university-level research computing options? I have my experiences, but I want to hear from others.

[ASBMB @ASBMB]

New job posting: Assistant Professor - Boston University Chobanian & Avedisian School of Medicine - Boston, MA https://t.co/M0ogyG3zi0 #ASBMBCareers

[davide calebiro @DavideCalebiro]

Dear microscopy developers, we're soon going to have two postdoc positions in my lab to develop an #AI driven #automated platform for high-throughput 5D #imaging applied to cell #signaling! Stay tuned and get in touch for more! @COMPARE_UoBUoN @unibirmingham @unibirm_CMH @UoB_MSS

[Tamir Gonen @gonenlab]

Folks please remember, when looking for a lab to join, always talk with current *and* past trainees. Joining a lab that nurtures and supports trainees is more important than where they publish.

I cant stress that enough. Join a lab that will help guide you in your career