Martin Zaehler

works in a ubiquitin lab

[Lior Pachter @lpachter]

I sure hope AI gets a high paying job because it's going to need $12,850 for each of the thousands of papers a month it's going to be publishing in Nature.

Also a concern is whether it will have enough left over every month to pay the mortgage for the data center where it lives.

[Feltham Lab @FelthamLab]

Proud to share The E3-ome

A true collaborative effort to unify the human E3 ligase landscape, and create a shared foundation for the field

#Ubiquitin #E3Ligases @WEHI_research

https://t.co/yK0jtcCp7P

[Hofmann_Lab @LabHofmann]

I am deeply saddened learning that my scientific hero Amos Bairoch has recently passed away. He will be remembered as the mastermind behind the SwissProt and many other endeavours in protein bioinformatics. There is a tribute web page at https://t.co/ku46u3iQVG

[National Centre for Biological Sciences @NCBS_Bangalore]

#ResearchExplained!
Proteins can be fragile and instable; @AravindR27 & team from Dr @RanabirNMR’s lab at NCBS developed CoreStab, a program that spots gaps in protein cores and suggests small changes to strengthen them.

Read here: https://t.co/ikiNtnR7UO

✏️Christeen Paulson

[Hofmann_Lab @LabHofmann]

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. https://t.co/274nqCYDeO

[Hofmann_Lab @LabHofmann]

Very interesting finding from the Escobar group next door, with some minor contributions from us.

[Ranabir Das @RanabirNMR]

Measure protein deamidation by bacterial secreted proteins? Check out the recent NMR paper. Congratulations to @Rashmi_Agrata
https://t.co/WGGjeSeWPS

[Martin Zaehler @MZaehler]

@AllThingsApx Will the code be available?

[Martin Zaehler @MZaehler]

@TerribleMaps In my experience, Denmark belongs to the "don't do that" countries

[Hofmann_Lab @LabHofmann]

Our paper on bacterial clippases is now out in @MolecularCell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to @UniCologne and @C2fBiochemistry for support.
https://t.co/78lxodHhQa

[Martin Zaehler @MZaehler]

@TerribleMaps https://t.co/pCbad5uFxH

[Hofmann_Lab @LabHofmann]

Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.

[Martin Zaehler @MZaehler]

@SFB_TPDvienna Looks like a lot of friends but very little ubiquitin

[John B. Holbein @JohnHolbein1]

Lol who did this

[Martin Zaehler @MZaehler]

@thaoshibe In Germany, it is more like 10-20 Euro for a A0-size poster. And we often use it 2-3 times. And eventually retire it to a poster wall in our lab building. Not that much of a waste, compared to other lab-related stuff.

[Malte Gersch @MalteGersch]

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! https://t.co/YTV5td5koG

[Pushmeet Kohli @pushmeet]

The #AlphaFold 3 model code and weights are now available for academic use. We @GoogleDeepMind are excited to see how the research community continues to use AlphaFold to address open questions in biology and new lines of research.

https://t.co/kVB9hWJZTI

[Martin Zaehler @MZaehler]

@ai4s_protenix Thanks for making this available! The try-out server mentioned on the web page offers the option to add covalent bonds, but this part doesn't seem to be operational. Is it part of the GitHub version?

[Ole Schmöker @oleschmoeker]

New Lammers Lab paper out now in @NatureComms!🥳
We reveal high functional diversity within bacterial deac(et)ylases by systematic functional/structural characterization.
This is Leonies PhD project and I’m grateful to have contributed to this great work.

https://t.co/UbAY45Hl5H

[Martin Zaehler @MZaehler]

@amazingmap Good correlation with using the kyrillic alphabet