MackenzieLab-Sweden

We work towards the neurocircuitry decoding of ”Why do we do what we do and not what we want ? (or intended to? ).” Complex behavior made simple.

[MackenzieLab-Sweden @MackenzieLab1]

We wanted to use the 6-OHDA model in combo with optogenetics in the STN but found mice did not cope so well. So we re-designed the protocol using lower dose and better peri-operative care. Full protocol leading to much improved survival; https://t.co/qaSYEKZUBR Current issue!

[MackenzieLab-Sweden @MackenzieLab1]

@CBaunez We are dissociating STN and paraSTN using promoter activities, not surgically (which I totally agree would be difficult!): Pitx2 vs. Tac1 promoters, used here to drive Cre expression in STN vs. paraSTN. We also tested Vglut2 and PV. 4 different Cre in optogenetics paradigms.

[MackenzieLab-Sweden @MackenzieLab1]

Proudly sharing our study on the subthalamic and para-subthalamic nuclei (STN vs. pSTN), and their different roles in behavioral avoidance and aversion. Great work by GP Serra et al: A role for the subthalamic nucleus in aversive learning: Cell Reports https://t.co/nZ3xA6ePOo

[eLife - the journal @eLife]

Deleting the enzyme Ptpmt1 from mouse hearts and muscles causes mitochondria to use fats instead of carbohydrates as an energy source, leading to tissue wasting, heart failure, and eventually death. https://t.co/yNhmSW1IwU

[MackenzieLab-Sweden @MackenzieLab1]

Happy to have visited GUBRA in Copenhagen! Very impressive technology for whole brain imaging.

[The Science of Parkinson's @ScienceofPD]

Brainstem neuromelanin & iron MRI reveals a signature for idiopathic (N=39) & LRRK2 (N=24) #Parkinsons cases; "While the SNc was a good discriminator between PD patients & controls, the LC was the structure that best discriminated among PD subgroups"
https://t.co/Q6TikpirYz

[MackenzieLab-Sweden @MackenzieLab1]

@womensbrainpro @ScienceofPD The sex and gender differences session at ADPD2023 was excellent! And people kept coming in … and together, we filled the huge lecture hall. Great to see such vast interest in this important topic. Thanks from one in the audience to all speakers for great lectures!

[MackenzieLab-Sweden @MackenzieLab1]

Checking the quality of my poster for the AD/PD meeting in Gothenburg, starting tomorrow. Translational histological study of the subthalamic area in mice and primate. Poster #0828. Come see! It looks rather neat! And important new data redrawing the maps!

[Anna M Biller @annambiller]

Dear @ESRS_Sleep board & #SleepEurope2022 people:
I have a dream💚 Let's start the next 50 years of #sleep research with a #sustainable travel initiative. I donate my 500€ worth ESRS travel grant to somebody who travels to our 2024 Sevilla Congress by train/bus*. Please RT!🌻

[MackenzieLab-Sweden @MackenzieLab1]

Today, Oct 4: 20 years since I defended my thesis at Karolinska Institutet! I remember how nervous I was but also the skill of the excellent faculty opponent, Kenneth Campbell, Ohio, who made it a nice event. Warmest thoughts to students defending their work today and every day!

[MackenzieLab-Sweden @MackenzieLab1]

#FENS2022 Session Basal Ganglia

[MackenzieLab-Sweden @MackenzieLab1]

Poster 5554 is up’n’running! A histological study of of the subthalamic area in primates - comparing with our previous results in mice. Come see!

[MackenzieLab-Sweden @MackenzieLab1]

Neuroscience Researcher Position. Deadline approaching: July 13! Welcome with your application!
Please RT

[MackenzieLab-Sweden @MackenzieLab1]

We are hiring! Are you the Neuroscience Researcher we are searching for? In-depth analysis of the subthalamus. See our ad: FENS Job Market. Visit our posters at FENS Paris! Welcome to apply! Researcher in neurobiology - Uppsala University, Sweden https://t.co/BfUtaeSP52

[MackenzieLab-Sweden @MackenzieLab1]

We are hiring! Are you the Neuroscience Researcher we are searching for? In-depth analysis of the subthalamus. See our ad: FENS Job Market. Visit our posters at FENS Paris! Welcome to apply! Researcher in neurobiology - Uppsala University, Sweden https://t.co/BfUtaeSP52

[Mackenzie Weygandt Mathis, PhD @TrackingActions]

Thanks @FENSorg & @EJNeuroscience for the award-it’s an honor to lecture on our motor learning work & #deeplearning tools to aid in this quest: @DeepLabCut @cebraAI.

Thanks to my mentors who taught me to be a scientist: T. Jessell, H. Wichterele, @naoshigeuchida @MatthiasBethge

[The Science of Parkinson's @ScienceofPD]

Wonderful interview with Prof Anders Bjorklund @Lund_Stem @lunduniversity - a pioneer & expert in cell replacement strategies for #Parkinsons - "Be open-minded, proactive, & open to sharing experience, knowledge, & information"
https://t.co/u80MFpFyQn

[NBIS @NBISwe]

New permanent bioinformatician positions available at NBIS in Uppsala Sweden! 1-2 in genome assembly: https://t.co/XOieeplQJD. 1 in evolutionary genomics: https://t.co/iMaMDsPuDQ. Deadline August 15.

[Christian Lüscher @LUSCHERC]

#optoDBS2022 is a wrap!

Many thanks to all speakers & participants for great science & stimulating discussions across the optogenetic-deep brain stimulation aisle.

Watch out for optoDBS2024 (tentatively June 12-14) again co-organized w/ @andreashorn_

https://t.co/GrWXrw6rIz

[Nand_Muley @Nand_Mule]

Last session of the day filed with exciting talks at #optoDBS2022. Next up, talks from Asa Mackenzie, @rlofredi, Debora Masini, @Steiner_LA and Nadine Gut
@andreashorn_ @LUSCHERC

[SWEBAGS @SWEBAGS_1]

For our last webinar this semester, we are proud to present Juan Mena Segovia from Rutgers University Ole Kiehn from University of Copenhagen that will join us the June 22 at 4 pm for the webinar "PPN inputs to striatum" https://t.co/ruhYNL23g1

[MackenzieLab-Sweden @MackenzieLab1]

Post-doc position: Neurocircuitry of the basal ganglia with focus on the subthalamic nucleus: Come join us! Fully funded post-doc position. 2 years with possibility for extension. Please RT. Welcome with your application by May 25! https://t.co/lrqCR8utoo