Rajith S Manan

#postdoc in Anderson/Langer lab @MIT @kochinstitute @MITChemE #organic chemist directed towards synthesis of biodegradable materials for drug delivery(mRNA)

[Rajith S Manan @MananRajith]

Glad to share my co-first author paper with @LukeRhym. Here we came up with peptide barcode novel screening method and screened novel 384 biodegradable lipids. We found RM-133-3 a highly potent lipid for the delivery of mRNA to liver @natBME #mrna

[Nature Biomedical Engineering @natBME]

Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery

https://t.co/hn1E5jpsCS

[The Nobel Prize @NobelPrize]

This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story:

“I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to raise. I was born in a family of refugees, and my parents could barely read or write. My father finished sixth grade and my mother couldn’t read or write. It’s quite a journey. Science allows you to do it. Science is the greatest equalising force in the world.

Smart people, talented people, skilled people exist everywhere. That’s why we really should focus on unleashing their potential through providing them with opportunity.”

Today Yaghi shared the 2025 Nobel Prize in Chemistry with Susumu Kitagawa and Richard Robson for their work developing metal–organic frameworks.

Learn more about the prize: https://t.co/4nmszg1ZIR

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

[Nature Reviews Drug Discovery @NatRevDrugDisc]

RNA chemistry and therapeutics https://t.co/F8UxINqmXk

This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab @WeissmanLab

[NOVA Medical School, Faculdade de Ciências Médicas @nova_medschool]

It is a true honour to welcome @MIT's Prof. Robert Langer - one of the world's most prolific scientists - to NOVA Medical School.
His groundbreaking work in biotechnology continues to inspire generations of researchers and innovators. https://t.co/fLmhpbuHaP

[Simon Liang @ShunqingLiang]

We are hiring!!!
https://t.co/3njZelg4pN
A Postoc position and a laboratory Researcher 1 position are available! Please send your CV to [email protected]
@UMN_GIHep @UMNews @NatureBiotech @NatureMedicine

[Koch Institute at MIT @kochinstitute]

Congratulations to Robert Langer of @MIT_ChemicalEng for winning the 2025 Lipid Science Prize! His groundbreaking work on lipids and polymers has revolutionized drug delivery & tissue regeneration. https://t.co/8bbPwCw41I

[Rajith S Manan @MananRajith]

Overall, this novel work shows the utility of deep learning in improving nanoparticle delivery to the liver and Lungs for gene therapy @NatureBiotech
@kochinstitute
@MITChemE
@MITBiology
@IowaMed @ScienceMIT

[Rajith S Manan @MananRajith]

I am excited to share my second co-first author paper@NatureBiotechon Designing Lipid Nanoparticles Using Deep Learning to Improve mRNA delivery for gene Therapy with collaborations from@JacobWitten1@w_idris@AllenYJiang@YizongHu Engelhard, Dan Anderson and Bob Langer

[Nature Biotechnology @NatureBiotech]

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy https://t.co/9yFO1kt09n

[Rajith S Manan @MananRajith]

Tested a diverse set of 1.6 million Ionizable Lipids developed from 4CR chemistry and found FO-32 and FO-35 were identified as top-performing lipids compared to existing clinical controls such as SM-102 and ckk-e12 in delivering mRNA to ferret Lungs @kochinstitute
@MITChemE

[Rajith S Manan @MananRajith]

@NatureBiotech @MITChemE @kochinstitute @MITdeptofBE @BostonChildrens @IowaMed @MIT_IMES @JacobWitten1 @w_idris @AllenYJiang @YizongHu @ChemistryMIT @moderna_tx Overall, this novel work shows the utility of deep learning in improving nanoparticle delivery to the liver and Lungs for gene therapy @NatureBiotech @kochinstitute @MITChemE @MITBiology @IowaMed

[Daniel Siegwart @DJSiegwart]

Exciting agenda at the @mrnaconference International mRNA Health Conference (November 12-14, 2024)

Come join us!

https://t.co/1MK0OLPpO4

[Lisa R Volpatti @LisaRVolpatti]

I'm hiring a research technician to help me build my lab at @NorthwesternBME @nu_chbe! The position requires residing in or relocating to Chicagoland for a May start date. RTs appreciated!
Read more and apply here: https://t.co/g3JUxFTBAh

[Rajith S Manan @MananRajith]

@Sreekanth_Vedas Congratulations @Sreekanth_Vedas

[Koch Institute at MIT @kochinstitute]

Looking for a deep dive into the science and engineering behind our #STATMadess competitors? Look no further!

Vibrating 💊https://t.co/4iWNoXdG0b

Gene therapy🫁
https://t.co/HHinnziNdS

Vote @MIT 🦫 https://t.co/silkC0qaQR

[Koch Institute at MIT @kochinstitute]

RNA-delivery nanoparticles from the Anderson & Langer Labs can perform gene editing in the lungs.

Researchers hope to adapt the nanoparticles to develop treatments for cystic fibrosis and other lung diseases.

Learn more: https://t.co/6e9HJQPWer

Vote #STATMadness ⬇️

[Jacks Lab @LabJacks]

We're hiring technicians! Apply below. https://t.co/GrunQEdoU3

[Rajith S Manan @MananRajith]

@Sreekanth_Vedas @NatureChemistry @ArghyaDeb16 @kokkonda2 Congratulations @Sreekanth_Vedas 👏