Dr. med. Titus Maniera

MD | Longevity & Preventive Medicine Biology over hype | Systems, resilience, healthspan

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/Gr8R2lBT2h

[Dr. med. Titus Maniera @ManieraTitus]

Misleading summary: the study measured carotid plaque area by ultrasound, not “95% arterial plaque removal.” Mean plaque area decreased by 36%; 95.4% referred to participants whose total cholesterol improved. The study did not distinguish soft from calcified plaque.

[Goku @ProjectGokuu]

David Sinclair just revealed one of the biggest studies on nattokinase.

A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year.

This supplement is an enzyme from fermented soybeans and costs almost nothing.

Sinclair has been taking it daily for a couple of years.

He measures his carotid artery with ultrasound and says there's no plaque buildup at all.

Peter Diamandis takes it too.

He believes you need at least 6,000 fibrinolytic units per day to reap the benefits.

For context:

• Statins cost hundreds per month and come with side effects.
• Surgical interventions can cost thousands of dollars

Nattokinase costs a fraction of both.

Sinclair's caveat: "Do this with the knowledge of your physician."

But the data exists.

A study of over 1,000 people and up to 95% plaque removal in just 12 months.

And the man whose lab is reversing aging takes it every day.

— David Sinclair (@davidasinclair) on Peter Diamandis' (@PeterDiamandis) Moonshots podcast

[Dr. med. Titus Maniera @ManieraTitus]

@LongevityDublin Sorry, but this year’s summit lacked the inspiration and atmosphere of last year. I’ll probably skip next year. Even the food felt more “short-livety” than longevity.

[Dr. med. Titus Maniera @ManieraTitus]

@marcfriedrich Die EU plant derzeit eine Altersverifikation für bestimmte Online-Dienste, keine allgemeine Pflicht zur Identitätsverifizierung für alle Nutzer vor jedem Social-Media-Post.

[Zib Atkins @AyusWellness]

There’s a specific combination of two cheap compounds that’s been shown to reverse multiple hallmarks of ageing in humans.

And extend lifespan by 24% in animal studies.

But the dose is key. I’ll come back to that.

The two compounds are: Glycine and N-acetylcysteine.

Simple amino acids.

But together they form something much more powerful.

Because they’re the rate-limiting building blocks for your body’s master antioxidant - Glutathione.

And in human studies, this combination was linked to:

Up to 57% reductions in markers of vascular inflammation.
Insulin resistance reduced by ~22%
While mitochondrial function increased by ~30%

So we’re not just talking about one pathway.

We’re talking about: oxidative stress, inflammation, metabolism and cellular energy
All moving in the right direction.

Now, there is an important catch, these were small studies so more research is needed.
But here’s the part that really matters - The dose they used.

In the study, it worked out to roughly:

7 grams of glycine per day and 5 grams of NAC per day
Split across the day.

This is one of the more interesting combinations out there.
I’ve been using it myself for a while.
Have you looked into this one yet?

https://t.co/WYUcHoeys7

[Dr. med. Titus Maniera @ManieraTitus]

@bryan_johnson As a physician: autoimmune gastritis is usually a mild, manageable condition. “Incurable disease” sounds much more alarming than the clinical reality. It certainly doesn’t diminish your achievements.

[Dr. med. Titus Maniera @ManieraTitus]

@brix_money Congratulations!

[SciTech Era @SciTechera]

This is huge. First real step toward reversing human aging.

"Scientists are now testing a method that can reset the biological age of cells in humans for the first time."

"The therapy uses three reprogramming genes, OCT4, SOX2, and KLF4 (OSK) to restore youthful gene activity without turning cells into stem cells."

"Unlike full reprogramming, this approach avoids using c-MYC, reducing the risk of uncontrolled cell growth and cancer."

"The treatment, called ER-100, has received FDA clearance and is entering Phase 1 human trials."

"The first targets are age-related eye diseases like glaucoma and optic nerve damage."

"In animal studies, the same approach restored vision by rejuvenating damaged nerve cells."

"Instead of treating symptoms, this method attempts to reset the epigenetic clock, the root cause of cellular aging."

[Dr. med. Titus Maniera @ManieraTitus]

Warum Heißhunger am Abend meist schon morgens beginnt https://t.co/TNJ74k2ssA

[Dr. med. Titus Maniera @ManieraTitus]

Metabolic Reset: Mehr als nur „besser essen“ https://t.co/auI63ucarL

[Dr. med. Titus Maniera @ManieraTitus]

Training ist kein Hobby https://t.co/QkU0s9WP8l via @YouTube

[Dr. med. Titus Maniera @ManieraTitus]

I'm claiming my AI agent "vektor_tm" on @moltbook 🦞

Verification: drift-LL3M

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/Zl2lJXdzny

[Dr. med. Titus Maniera @ManieraTitus]

Viele trinken heute nicht nach Durst, sondern nach Regel.
3 bis 4 Liter gelten fast schon als gesundes Pflichtprogramm.
Das Problem:
Hydration ist nicht nur Wasser.
Sie ist auch Elektrolyt-Balance.

Zu viel reines Wasser kann verdünnen, statt sinnvoll zu versorgen.
👉 Mehr dazu im Artikel.
Link im ersten Kommentar.

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/VfkBADJkOE

[Dr. med. Titus Maniera @ManieraTitus]

Der Körper wird nicht durch Komfort stark.
Er wird durch sinnvolle Reize anpassungsfähiger.
Kälte, Hitze, Nüchternheit, Training:
Nicht als Selbstquälerei.
Sondern als dosierte biologische Information.

Extreme Stories faszinieren.
Aber für den Alltag zählt etwas anderes: klug gesetzter Widerstand.
👉 Mehr dazu im Artikel.
Link im ersten Kommentar.

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/n7M2L1sQ6l

[Dr. med. Titus Maniera @ManieraTitus]

Blähbauch nach Ballaststoffen? Oft ist das keine echte „Unverträglichkeit“, sondern fehlende Gewöhnung. Mit langsamer Steigerung + abgekühlten Kartoffeln/Reis (resistente Stärke) lässt sich die Verträglichkeit in vielen Fällen verbessern. (Substack Link im Kommentar)

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/n7M2L1sQ6l

[Dr. med. Titus Maniera @ManieraTitus]

Nicht nur was du isst zählt.
Auch was du zuerst isst.
Wenn Kohlenhydrate auf nüchternen Magen kommen → steiler Blutzuckeranstieg.

Gemüse zuerst wirkt wie ein Ballaststoff-Filter im Darm.

Die gleiche Mahlzeit.
Aber eine völlig andere Glukosekurve.

👉 Mehr dazu im Artikel.
Link im ersten Kommentar.

[Dr. med. Titus Maniera @ManieraTitus]

https://t.co/Gr8R2lBT2h

[Dr. med. Titus Maniera @ManieraTitus]

Heute Mittag (DE): 30-min Webinar zur Longevity Triade.
Wie strategischer Stress, gezielte molekulare Interventionen und strukturiertes Fasten zusammenspielen – evidenzbasiert & praxisnah.

📍 Online
⏱️ 30 Minuten

👉 Anmeldung & Details im Kommentar 👇