Great to see how Integrator embraces the paused transcription complex to engage with nascent RNA and trigger Pol II attenuation. Paper by @isaac_fianu et al. edited by @dijiang319 is out @ScienceMagazine:
https://t.co/hx8rb9Awly
My lab @MRC_LMB is recruiting #PhD students!
We study the mechanism of transcription-coupled alternative splicing using #cryoEM, biochemistry and cellular assays.
Details of the project: https://t.co/Ud5RRaw5Px
Application deadline: 2nd December
Please RT! Thank you☺️
Sorry for repeating ourselves - but we are speechless AGAIN!😯🙂😯🙂😀🎉🤗🙃😯😁😃😁😯🙃🍾🎉😀🙂😃😁😯🙃🤗🍾🎉😀🙂😀🎉🍾🤗🙃😯😁😃😁😯🙃🤗🍾🎉😀🙂😯🙂😀🍾🎉#NobelPrizeChemistry2021 Benjamin List @maxplanckpress Max-Planck-Institut für Kohlenforschung🤗😯🙂😀🍾😯🎉🤗🙃😁😃😁🙃🤗🎉
We are speechless!🎉🙃😃🎉🎉🙃😃🤗🙃☺️🙃🙂😄🎉#NobelPrizePhysics 2021 😀🙃🎉☺️Klaus Hasselmann @MPI_Meteo😃🎉😃😀🙃😀🎉😊🙂🙃😀😄🎉@maxplanckpress🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🎉🙂🎉☺️🙃🎉🙂😀☺️🙃🎉🙂😀☺️🙃😀🙃😂😀🎉 😊🙂🙃😊😀😊🙃
Our work describing human transcription-DNA repair coupling in five ❄️EM structures is out @Nature. 🧬🥳
The centrepiece of coupling is the alternative transcription elongation complex that can ubiquitylate lesion-arrested Pol II and initiate DNA repair.
https://t.co/qzHlgXntqa
My first review now available as a pre-proof!! @TaatjesL@JMolBiol Merging established mechanisms with new insights: Condensates, hubs, a... https://t.co/jf4LutQL6g
A study in @NatureSMB reveals how the COVID-19 antiviral drug candidate molnupiravir causes lethal viral mutagenesis by the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. https://t.co/s2saMQZueN
AlphaFold2 and the future of structural biology: Patrick Cramer @CramerLab @mpi_bpc discusses the recently launched #AlphaFold2 by @DeepMind and how it will impact structural biology.
https://t.co/deGUjGkeXB
Nanobodies aus #Alpakas könnten irgendwann dafür sorgen, dass sich eine #Corona-Infektion gut behandeln lässt. Wie diese "Mini-Antikörper" funktionieren, erklärt Dirk Görlich @MPI_BPC in diesem spannenden Podcast 🎧https://t.co/S3iIceiYrQ #Forschungsquartett@detektorfm
EMBL and @DeepMind have partnered – a breakthrough for science.
Together, we're providing a treasure trove of protein structure predictions powered by #AlphaFold to herald a new era for #AI-enabled biology.
https://t.co/QSM55eB2Fk
Out now! The high-resolution structure of the yeast pre-initiation complex and the defined mechanism of initial DNA opening in transcription
#microscopy#RNA#DNA
@CramerLab @mpi_bpc
https://t.co/eg6uNmMdm0
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: https://t.co/vtBGmTkKhy 1/
Last year we presented #AlphaFold v2 which predicts 3D structures of proteins down to atomic accuracy. Today we’re proud to share the methods in @Nature w/open source code. Excited to see the research this enables. More very soon!
https://t.co/6uiV51Xly5
https://t.co/CLo7EKubBT
How can #AI help us speed up scientific discovery? We’ve teamed up with @DeepMind to make #AlphaFold protein structure predictions freely and openly available to the scientific community.
https://t.co/Lq2aUvjkQS
#FAIRdata#structuralbiology#opendata
Two popular machine-learning systems for predicting protein structures from amino acid sequences are now open-source and freely accessible. https://t.co/VAoNk0X6Lc