Thomas Güttler

Cell Biologist, Biochemist & Structural Biologist. Biotech Leader.

[Ronald Breaker @RonBreaker]

#ncRNA molecules are stranger than you think. We propose that OLE RNA is bacteria's functional mimic of
#mTOR. The Das lab at Stanford proposes OLE RNA penetrates cell membranes! They also find that RNAs we called ROOL and GOLLD form 8-membered nanocages. https://t.co/DQ7Zr5p6DT

[Haselbach lab @HaselbachLab]

Wow 365 million domains identified. Really amazing push forward for Structural biology. and a wonderful new resource. Today in Science: https://t.co/O6p2jf0RGv

[Petr Těšina @petesoi1]

This looks amazing, can't wait to read it properly! Congrats to everyone involved @LabConti @KeidelAchim

https://t.co/wSvPC8Scnd

[Ahmad Jomaa @jomaa_lab]

Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! https://t.co/DE6eAamt5I

[Max Clabbers @maxclabbers]

Excited to share our latest preprint @gonenlab @ScienceMick, where we demonstrate how an energy filter can significantly enhance macromolecular MicroED data quality - showing diffraction spots extending to ~1 Å resolution from proteinase K xtals: https://t.co/tIdonJWaOY

[Tamir Gonen @gonenlab]

#cryoEM with energy filter & electron counting significantly increased resolution even for a full size protein like proteinase K. Sub-atomic resolution #MicroED rivals best reported Xray of Proteinase K but by using crystals a billionth the size. A section of the map is shown

[Eric Topol @EricTopol]

The promising pan-sarbecovirus vaccine from @Caltech
https://t.co/PcLhsPR5Sx @CellCellPress

[Yuh Min Chook @yuhminchook]

Shoutout to former/current @ChookLab members - Ertugrul Cansizoglu for starting the work and taming Msn5, Takuya Yosizawa for getting over the big barrier of phosphorylating Pho4, and the amazing Joyce Fung for putting it together and showing how it works!
https://t.co/w3hANQnaDA

[SBGrid: Structural Biology Software @SBGrid]

Future directions in drug development against antibiotic resistant bacteria: a publication highlight from @KeAndreya_M of @MeharryMedical featuring an article from the lab of Daniel Kahne at @HarvardMedical.

Read more here: https://t.co/EQLUtEIPxt

[Misha Kudryashev 🔬 ❄🕊️ @MishaKudryashev]

This is an elegant study showing the differences in structures of hemoglobin in humans and crocodiles which explains why crocs can stay long under water. Very cool 🐊🐊🐊

The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM
https://t.co/eKdbtd2cng

[Yong Xiong Lab @Xiongosome]

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!

https://t.co/ScWOAQRjTw

[eLife - the journal @eLife]

This landmark #ReviewedPreprint represents “the most significant breakthrough in membrane and secretory biogenesis in recent years.”

‘Structural analysis of the dynamic ribosome-translocon complex’
https://t.co/03eD9vjm54

[Thomas Güttler @Thomas_Guttler]

@EOberbeckmann @yourUMG @mpgpresident @lidschreiber @c_dienemann Congratulations, Elisa!

[Science Magazine @ScienceMagazine]

In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds.

Learn more on #DNADay ⬇️
📄: https://t.co/GlRfbfSUt6
📄: https://t.co/R22Dk0HVyo

[Thomas Güttler @Thomas_Guttler]

New paper in @embojournal, with special shoutout to lead author @MireiaSol6, who (as I learned) is not Twitter-less 🎉!

[Thomas Güttler @Thomas_Guttler]

A checkpoint function for Nup98 in nuclear pore formation, elucidated with nanobodies. Congratulations to the entire team @mpi_nat @GunkelPhilip @pleinerlab !

[The EMBO Journal @embojournal]

A nanobody toolkit for tracking or blocking nuclear pore complex (NPC) biogenesis identifies a checkpoint linking assembly of the NPC scaffold to formation of the Np98-dominated permeability barrier

Dirk Görlich and coworkers
@NPC_aficionado @mpi_nat

https://t.co/Ff0EU5MMBJ

[The Royal Society @royalsociety]

It's #NationalPigDay! This little character is Cavia porcellus, or the Guinea Pig (though neither from Guinea nor closely related to pigs). For a Friday brain-teaser, could you guess what other creature this rodent is standing next to? We'll reveal the answer this afternoon!

[Eri Sakata @Eri_RS_Sakata]

After a long journey, I am thrilled to announce that our collaborative paper is finally out in @NatureChemistry ! Can cryo-EM capture the metastable ADP.Pi state, where ATP is hydrolyzed but ADP and the cleaved Pi ion still remain in the nucleotide pocket?https://t.co/OmhAkIAGGe

[Sebastian Guettler Lab @SGuettlerLab]

Come and join us as Cryo-Correlative Workflow Specialist & Microscopist (at Senior Scientific Officer level, with permanent contract) @ICR_London, to help build in-situ structural biology. #CryoEM #CryoET Details here: https://t.co/ZtsRMFuFli