Maria Jose Donde

Wellcome Trust PhD student developing XNA precision medicine 🧬 Taylor lab, University of Cambridge

[Megan Gozzard @PhDood1es]

What geneticists fear the most: The Cambridge Plot.

[Megan Gozzard @PhDood1es]

Really enjoyed illustrating for the @sangerinstitute blog reporting the publication of the first draft #pangenome ✏️

[Alex Taylor @Taylor_Lab_KCL]

Very well deserved congratulations to my student @MariaDonde2 who has won one of this years’ PhD student awards from the Cambridge Society for the Application of Research (CSAR) for her work on XNAzymes! Well done Maria! https://t.co/nIruy8Gvhc

[Jake Thomas @JakerrThomas]

Excited to see this work from my PhD with @McGovernLab finally out! The revised study now includes fascinating epigenetics data from @annappios and @cw_hanna showing how HLA class II expression is initially silenced in human primitive macrophages. Check it out! 👇

[Maria Jose Donde @MariaDonde2]

I am very excited to share the new paper from the lab. We are using XNAzymes to cleave SARScoV2 ✂️ Many congrats to @Taylor_Lab_Cam for getting big part of this done while on lockdown!

[Alex Taylor @Taylor_Lab_KCL]

🚨Paper in @NatureComms w/ @pehuen87 #COVID19 hit as I started my lab, so I explored the potential of artificial enzymes to target #SARSCoV2 RNA, engineering catalytic nanostructures to chop the genome & inhibit #coronavirus replication in cells #synbio https://t.co/z6yDHKcoUp

[Katharina Zühlsdorff @katha_zuehli]

Have you ever wondered what the neural substrates of changing your mind are? 🤔🧠 find out in our new article: https://t.co/YmQ64tML5E
@MoreinLab @CamNeuro

[Alex Taylor @Taylor_Lab_KCL]

Formal at @MECCambridge with my brilliant PhDs @MariaDonde2 & @g_dhaliwal1 - Thank you X-women

[Niklas Freund @Niklas_Freund1]

Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids.

https://t.co/u8ymvACrEZ

🧵(1/n)

[Maria Jose Donde @MariaDonde2]

@thelowlab @Taylor_Lab_Cam Thank you! Yes this side project kept me sane during my first year of the PhD so I am very happy it is out and got my first first author 😇

[Maria Jose Donde @MariaDonde2]

Check out our new paper showing how we re-targeted XNAzymes to cleave individual miR and Y RNA! Thanks to everyone involded and especially @Taylor_Lab_Cam.

[Alex Taylor @Taylor_Lab_KCL]

🚨 New paper in @CommsBio by brilliant student @MariaDonde2 ! We engineer XNAzymes to selectively cleave individual disease-associated non-coding RNAs (microRNAs, Y RNA) in families of similar seqs – a route to precision modulation of RNA networks? #synbio https://t.co/tYIlv3CMO5

[Communications Biology @CommsBio]

Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated ncRNAs in vitro, with the potential for precision detection or knockdown of individual microRNAs or longer ncRNAs.

@Taylor_Lab_Cam @MariaDonde2 @Cambridge_Uni

https://t.co/Q7eMz3GlXJ

[Alex Taylor @Taylor_Lab_KCL]

🚨Article in @NatureChemistry w/ @PhilHolliger @ChrisJWan Using test tube evolution of synthetic nucleic acids we engineer artificial RNA-cutting oligo enzymes that cleave transcripts in cells w/single-nucleotide precision #synbio
https://t.co/lLXiVLIo3q
&
https://t.co/zxBJmMrzPa

[Alex Taylor @Taylor_Lab_KCL]

Delighted to share this new paper w/ @JackHervey - front cover of @rsc_chembio ! Here, we develop & evaluate systems for synthesis of pure & mixed-chemistry synthetic oligo libraries, paving the way to directed evolution of fully-biostable polymers #synbio https://t.co/FcE5u40Ocy

[Alex Taylor @Taylor_Lab_KCL]

I’ve published a ‘Matters Arising’ article in @NatureChemistry in collab with @PhilHolliger in which we examine a modified version of the 10-23 DNAzyme, “X10-23”, described by the labs of Profs. John Chaput and Robert Spitale (UC Irvine) – A thread (1/10) https://t.co/e3FuQJCYzY

[Maria Jose Donde @MariaDonde2]

Please support us this Sunday as we run the Cambridge 1/2 Marathon for @teamaruk !
Please donate below👇
https://t.co/FXYiHhcqJp
Only a few pounds can go a long way.... like buying one of these tubes or paying the PhD student holding them yearly stipend !

[Jake Thomas @JakerrThomas]

Ever wondered how Hofbauer cells (human fetal placental macrophages) are generated during pregnancy?

We aimed to investigate this in our latest preprint!

https://t.co/fSmNsUfFzp

[Maria Jose Donde @MariaDonde2]

@AntibodyBoy Realising you are the only PhD student in the Taylor lab...

[Alex Taylor @Taylor_Lab_KCL]

🚨 Interested in a @Cambridge_Uni PhD? Think synthetic biology, artificial oligonucleotides & precision medicines sound cool? Come join the Taylor lab!👽🧬
Applications now open for Oct 2021 entry to a new PhD prog in infection & immunity https://t.co/1NELgtcuFr
RTs appreciated!