Martin Bootman

Lover of sport, science, communication, friendship, adventures, and my gorgeous, wonderful daughters.

[Martin Bootman @MartinBootman]

@LMCSLeuven Yesterday was a brilliant celebration of Flore’s great work. Great teamwork!

[Geert Bultynck 🇺🇦 @LMCSLeuven]

The review is the product of truly great, inspirational and collaborative endeavor with our 2 PhD students (Flore Sneyers & Femke Speelman-Rooms) and our ChemBio partner @VerhelstLab and Calcium partner @MartinBootman! 🙏for your help, input & feedback throughout the work!

[Geert Bultynck 🇺🇦 @LMCSLeuven]

Science requires proper controls. BAPTA evoked MCL-1 downregulation, so "Ca2+ drives MCL-1 abundance"? It turned out that TF-BAPTA (Kd 65 µM, far off 100 nM basal [Ca2+]) too evoked MCL-1 decline! So, Ca2+ chelation was not the cause. Our journey led to direct PFKFB3 inhibition!

[Geert Bultynck 🇺🇦 @LMCSLeuven]

#calcium #BAPTA #controls #PFKFB3 #MCL1 #cell_death @EuroCalcium
It wasn't easy and risky working on an "off-target". But, we found it worthwhile to properly interpret findings as BAPTA is used in >1000s studies but also learning new things such as PFKFB3 linking to MCL-1.

[Geert Bultynck 🇺🇦 @LMCSLeuven]

Happy to share @cddpress paper by Flore Sneyers identifying PFKFB3 enzyme as direct target of intracellular Ca2+ chelator, thereby accounting for Ca2+-independent inhibition of mTORC1, MCL-1 downregulation and cell death in MCL-1-addicted cells!
https://t.co/wWURksJOzS

[CoolLED @coolLEDltd]

What better way to the start the week than by reading our amazing new #AppNote, with many thanks to @MartinBootman.

Find out how he used rapid, high resolution #fluorescence measurement techniques to study mitochondrial membrane flickers...
https://t.co/Px2lpfMnVP

#microscopy

[Martin Bootman @MartinBootman]

@danmjohnson @JMCCardiology @ChrisToepfer Interesting study! Unfortunately, there are wider cellular issues with calcium indicators and BAPTA too. https://t.co/no9MBdB6PA doi: https://t.co/lVsSn7hWqM

[Martin Bootman @MartinBootman]

@jaketapper Best wishes to you and your family Jake. With your daughter’s recent traumatic health issue, and now losing Tom, you’ve been through a lot. I can empathise with your situation and loss. Sincere sympathy to you all.

[Geert Bultynck 🇺🇦 @LMCSLeuven]

A special word to … @MartinBootman. Thanks AV-man! 🤣 🙏 @MaleneBrohus and @pchoern for many small & big things and your continuing enthusiasm & support with @EuroCalcium Board! 🙏 @T_Luyten for all your help throughout! Definition of friends: they help out without asking! 🙏

[Peter Stefanovic @PeterStefanovi2]

Jeez. In the first 30 minutes of tonight’s Tory leadership debate Rishi Sunak & Liz Truss managed to completely eviscerate the whole Tory Government

Watch in disbelief

[Chemistry at The Open University @OU_chemistry]

Great work from the OU! Support for Ukrainian refugees and for host families.
https://t.co/mGroG0SGUI

[Geert Bultynck 🇺🇦 @LMCSLeuven]

Tired but satisfied after 3 days of exciting in-person CaSign WOG event supported by @FWOVlaanderen and Hamamatsu Photonics (with eg @roderick_cardio; @licr_leuven) filled by excellent talks from ECR’s and international in-person attendees @MartinBootman @joachimgoedhart

[Taufiq Rahman @RahmanLab]

#Signalling and #calcium signalling enthusiasts - you are all cordially invited to this exciting 'science-day-out' in a scenic setting of Queens' college, Cambridge @MartinBootman @MarchantLab
https://t.co/oPGtVaQGck

[jECS @EuroCalcium]

Here are the four session topics for the #jECS2021 meeting! We're open for abstract submission here: https://t.co/wBIhteENhf - deadline September 15! We select posters and 12 talks from abtracts! 🤩

[Cycling on TNT Sports @cyclingontnt]

"This is Olympic spirit!"

Lotte Miller consoles Claire Michel - the final athlete to cross the finish line in the women's triathlon ❤️

#Tokyo2020 | #Triathlon

[Martin Bootman @MartinBootman]

@emlizc Tip...? Get a super organised PhD student and enable them with a label printer! They are then happy labelling and out of trouble all day! You're welcome @emlizc 😉

[jECS @EuroCalcium]

Today is the #ECSWebinar one year anniversary!

Huge thank you to all those who have attended and supported our 26 wonderful speakers and counting...

For more information on past and present webinars: https://t.co/MF0Teww6OI

[jECS @EuroCalcium]

The first webinar was presented by Don Gill on 14th May 2020.

Recordings of Don’s talk and many others can be found on the jECS YouTube channel: https://t.co/85RbMfhYUj

[jECS @EuroCalcium]

Introducing ECS member Tim Vervliet: ECS junior board member! #ECSmemberprofile #jECSboard

For more information about Tim’s research at KU Leuven, Belgium @KU_Leuven: https://t.co/xihWXPxUJo

[Lindsay O'Dell @lindsay_odell]

I'm really proud of this project