SV Mathan

#Immunotherapy #Cancerstemcells #Stemcells #Microbiome #Cancermetabolism #Cellbiology #Radiation #TME #metastasis #diet #aging #lifestyle

[Eric Topol @EricTopol]

How a low protein diet improves the immune response to pancreatic cancer, reshaping the gut microbiome, in the experimental model and patients
https://t.co/0MYwzfMsqf

[Eric Topol @EricTopol]

Thymulin, the peptide derived from the thymus, suppresses age-related inflammaging and, in the experimental model, helps protect vs cancer
https://t.co/gn2GmkBEI6

[Omer Yilmaz @ohyilmaz]

New study from our lab: a ketogenic diet has opposite effects on intestinal tumors in mice — accelerating them in the small intestine, suppressing them in the colon. Neither effect requires ketones — dietary lipid content drives both. https://t.co/KebbnVM2Qh

[Nature Reviews Cancer @NatureRevCancer]

NEW content online! Imaging the hallmarks of cancer https://t.co/f74UrnEvJb

[Cancer Cell @Cancer_Cell]

Online Now: High-plasticity oncofetal cell states in early pre-metastatic colorectal cancer https://t.co/WJfRS0aqv6

[Eric Topol @EricTopol]

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)

[Nature Reviews Cancer @NatureRevCancer]

#REVIEW 🚨
How does #exercise reduce cancer risk? Zhuang et al. propose that physiological adaptation to aerobic activity reshapes adult stem cell behaviour, limiting transformation and tumour initiation
📖⬇️
https://t.co/aZ2RxF0eZ2

[Mara Sherman Lab @MaraShermanLab]

@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. https://t.co/9nNnkvh3wX

[Eric Topol @EricTopol]

In cancer, activated T cells release abundant extracellular vesicles that transfer DNA to the nucleus of tumor and immune (dendritic) cells, turning tumors from cold to hot. An immunotherapy in the works. @Cancer_Cell
https://t.co/mHcahijOJC
https://t.co/oPT6d7lrFM

[Cell @CellCellPress]

Now online! Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition https://t.co/UT2moGWAiv

[Dr. Patrick Hwu @PatrickHwuMD]

🧬 #ScienceSaturday

❓ What if we could block cancer’s ability to survive in low-oxygen environments and make #immunotherapy more effective?

➡️ In a new study published in the Journal of Experimental Medicine (@JExpMed), researchers developed dual inhibitors targeting HIF-1 and HIF-2, key regulators that help tumors adapt to hypoxia.

➡️ These compounds bind HIF proteins, block their activity and trigger their degradation, shutting down pathways that drive tumor growth, angiogenesis and immune evasion.

➡️ In preclinical models, dual HIF inhibition suppressed tumor growth across multiple cancer types and outperformed selective HIF-2 inhibitors.

➡️ When combined with immune checkpoint blockade in murine models, response rates exceeded 50% and helped overcome resistance to immunotherapy.

🌟 Targeting #hypoxia may help reprogram the tumor microenvironment and unlock stronger immune responses.

🔗 Read the study: https://t.co/JqceQpWjlL

@JohnsHopkins @HopkinsMedicine @umsop @eewicks @onlyoscarli

[Eric Topol @EricTopol]

How and why tumors metastasize to the brain, an excellent review
@scisignal
https://t.co/coJjVwi7X9

[Laura Attardi @AttardiLaura]

Thrilled to share our new review article on #p53 and #plasticity in @trendscancer - p53: defender of lineage fidelity and foe of plasticity in cancer and regeneration @arati_rajeevan https://t.co/83q2cYFa9N

[Waggoner Lab @LabWaggoner]

uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical models @CellCellPress @LoweLabMSKCC
@Columbia
https://t.co/CF0ePlwicg

[Anirban Maitra @Aiims1742]

Multiple recent papers (two just this week) highlighting the role of inflammation in sculpting “epigenetic memory” and promoting tumorigenesis across various solid organs.
https://t.co/N3tAKyGluC
https://t.co/dbTqy9rTQr
https://t.co/M2TuFCKRea
https://t.co/iav4PoFH1d

[Eric Topol @EricTopol]

More today on exercising fathers and metabolic health of offspring, summarized https://t.co/BMIvUaRjvD

[Arc Institute @arcinstitute]

CAR T cell therapy has shown strong results against certain cancers, but metabolic exhaustion limits its effectiveness over time.

In @CellCellPress, the @MaayanLevyPhD & @ChristophThaiss labs report that a common supplement can fuel CAR T cells to fight cancer more effectively.

[Maria Alcolea @MariaPAlcolea]

🚨 New paper from our lab just published in Nature🚨https://t.co/mA7cSa10eP

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning.

Fantastic team led by @GSkrupskelyte, Eduardo Rojo, Harikrishnan Ajith

[Judith Agudo @JudithAgudo1]

Metastasis kills most cancer patients and grows from invisible seeds. How do these seeds escape from attack by immune cells? These seeds harness stress hormones!🤯
⁦thanks to ⁦@nyscf⁩ ⁦@parkerici⁩ for their support. Today at ⁦@Nature⁩ https://t.co/rMKnHEqQwb

[Cell Metabolism @Cell_Metabolism]

Restricting lipid accumulation in tumor-infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects https://t.co/uh1Qz3RBVi