Michael Colwell

Postdoctoral researcher in Cognitive Neuroscience @UniofOxford

[Michael Colwell @MichaelJColwell]

New paper in Nature Comms @NatureComms !

If you're interested in serotonin and its influence on human behaviour, you may enjoy our new paper. We use a now-available method to increase brain serotonin that differs from conventional methods (e.g., SSRIs).

https://t.co/PPQgil4dwF

[Nicholas Fabiano, MD @NTFabiano]

Serotonin reduces sensitivity to aversive contexts.

🧵1/10

[University of Oxford @UniofOxford]

NEW: Researchers have found increasing serotonin makes people better able to control their behaviour, particularly when exposed to negative information.

More info ⬇️
https://t.co/AZOFKiRO80

[CLaE @leafs_s]

Serotonin changes how people learn and respond to negative information
https://t.co/fWMhcEHAdB

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging
https://t.co/4N6LW7dn84

[Michael Colwell @MichaelJColwell]

@EllaMgdo @NatureComms Thank you!

[Michael Colwell @MichaelJColwell]

New paper in Nature Comms @NatureComms !

If you're interested in serotonin and its influence on human behaviour, you may enjoy our new paper. We use a now-available method to increase brain serotonin that differs from conventional methods (e.g., SSRIs).

https://t.co/PPQgil4dwF

[Michael Colwell @MichaelJColwell]

@zenbrainest @mattbagg Thanks for sending your papers on! I will have a read tomorrow for sure. BTW I did not mean to suggest they are the same thing, but rather one supersedes the other.

Would you be happy to speak over email? It's difficult to have a considered discussion re: character limits etc.

[Michael Colwell @MichaelJColwell]

@zenbrainest @mattbagg Interesting. Do you mind sending on a paper? Fenfluramine itself has <1% binding affinity for 5-HT2B/C vs endogenous 5-HT.

[Michael Colwell @MichaelJColwell]

@zenbrainest @mattbagg We used low-dose fenfluramine our study. Fenfluramine is no longer selective to serotonin at high doses, and indeed, we know the effects on VHD are dose-dependent: https://t.co/kZEkUKTJld

[Michael Colwell @MichaelJColwell]

@zenbrainest We discuss this in quite a bit of detail in the paper. I've highlighted the specific section. Happy to discuss further.

[Michael Colwell @MichaelJColwell]

@mattbagg Thanks! That is interesting; firing-independent release is helpful in the sense that it is less deterred by autoreceptor supersensitivity (which delays the action of SSRIs), producing a less muddied picture of temporal/spatial aspects of 5-HT signalling. But, no method is perfect

[Michael Colwell @MichaelJColwell]

@yonicoud @NatureComms Thanks Yoni! Hope all is well in Bordeaux.

[Michael Colwell @MichaelJColwell]

@dr_alexharris Thank you! While not always, aversive RL is typically increased in depression, while reward RL is reduced (see https://t.co/xW7nRCGMTB). It is tempting to speculate that this drug could reduce aversive RL in MDD, but this needs testing empirically in a clinical cohort.

[Michael Colwell @MichaelJColwell]

Our press release:

https://t.co/Hyw6GuidLF

[Michael Colwell @MichaelJColwell]

If you have any questions, please do drop me an email or I can reply here! Email: [email protected]

[Oxford PERL Lab @OxfordPERL]

The serotonin releasing agent fenfluramine enhances memory, reduces impulsive responses and sensitivity to negative consequences, translating work from preclinical models to humans, by Michael Colwell @SusieMurphy ://inews.co.uk/news/why-antidepressants-work-serotonin-3215154"

[Michael Colwell @MichaelJColwell]

https://t.co/PPQgil4dwF

[Michael Colwell @MichaelJColwell]

Thank you to @theipaper for an interesting and well-balanced take on our latest paper:
https://t.co/JD1e67EAaW #serotonin