Michaela Novotná

Now active at 🦋 only:
💎ribosome 🧫resistance 🧬ABC-Fs 🦠staph

[Zeynep Baharoglu @BaharogluZeynep]

Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria 🦠 https://t.co/zbzDR1d18f

[Michaela Novotná @MichaelaNov_]

Latest work of our lab published in Nature Chemistry

[Czech Academy of Sciences @CzechAcademy]

#newpaper | Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes

University of Tokyo @UTokyo_News_en & Institute of Microbiology of the CAS collab

Study ➡️ https://t.co/7dkGjDG3gu #nextgeneration #antibiotics

[Akademie věd ČR @Akademie_ved_CR]

💊Triky přírody: vědci odhalují, jak vznikají nová antibiotika

🧪 Ztráta účinnosti antibiotik v důsledku rostoucí odolnosti patogenních bakterií představuje stále větší výzvu pro moderní medicínu a vědu. Výzkumníkům z Mikrobiologického ústavu AV ČR ve spolupráci s vědci z Tokijské univerzity se podařilo dešifrovat klíčový molekulární mechanismus, kterým příroda – konkrétně půdní mikroorganismy – vytváří antibiotika ze skupiny linkosamidů.

Více ⬇️
https://t.co/Ete2wsZJ1u

[Vasili Hauryliuk @hauryliuk]

https://t.co/QiEtefdGfK

[Zeynep Baharoglu @BaharogluZeynep]

News on ribosome hibernation 🦠Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins: Structure https://t.co/simo3WLSmT

[Yaser Hashem @Hashemyaser4]

It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms
https://t.co/Ly7JeipU8W

[Yaser Hashem @Hashemyaser4]

Finally! Principles for ions binding to RNA, derived from a high resolution structure of the bacterial ribosome, very handy for accurate assignment of ions (and by extension, of water molecules) in ribosome/RNA structures 🤓

https://t.co/j6V4TfKXOW

[Olivier Duss @OlivierDuss]

First paper of our lab today @Nature by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl

https://t.co/ui1h01VaQW

[NIVB - Národní institut virologie a bakteriologie @NIVBcz]

V sobotu 30. listopadu 2024 se na ÚOCHB uskutečnil Grant Writing Workshop pod vedením Dr. Carlose V. Mela z Univerzity Karlovy.
Účastníci se věnovali psaní abstraktů, stanovování výzkumných cílů a tvorbě narativního CV.

[Molecular Cell @MolecularCell]

Online Now: Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching https://t.co/yqjEoOVDuW

[Jürgen Lassak @JurgenLassak]

How to regulate translation of proline containg proteins by the metabolic state of the cell? Finally out in Nat. Commun. Great collaboration with @lab_nmr @pavelkielkowski @qifei9 and Dimitrij Frishmans group: https://t.co/I78d52AZWp

[AlbertW_lab @AlbertW_Lab]

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: https://t.co/Ni4nJGJAug
The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7

[Sergey Melnikov @SergeyVMelniko1]

Actinobacteria appear to possess a species-specific ribosome hibernation factor, found in Mycobacteria, that binds to the nascent tunnel of dormant ribosomes. More in this exciting study by Ojha and Agrawal lab: https://t.co/uM6AMtB4mR

[Israel Fernandez @IsraelF96135088]

Nice short/introductory review in all things ribosomes by pioneer Harry Noller in the special 50 years issue of Cell.

The ribosome comes to life: Cell https://t.co/iwPh7gyO0h

[RiboSeqOrg @RiboSeqOrg]

A manuscript describing https://t.co/0oPzGld1bi is out in 2025 NAR db issue: https://t.co/QEtnylcV7w
It introduced RiboSeq Data Portal: https://t.co/HMGBFrzKAr

[Sergey Melnikov @SergeyVMelniko1]

This new preprint from the Cate lab provides insights into the fate of ribosomes in stationary archaea. Using an organism adapted to 95°C, they identify a protein called Dri, which appears to act as an archaea-specific ribosome hibernation factor: https://t.co/geGFd7inEm

[bioRxiv Microbiology @biorxiv_micrbio]

Evolutionary divergence of drug-binding sites in bacterial ribosomes https://t.co/5GsEC8LDco #biorxiv_micrbio

[WilsonLab @WilsonLab2]

Paenilamicins bind to a unique site on the ribosome to inhibit protein synthesis | Nature Chemical Biology…https://t.co/9gLCapflO8 https://t.co/1YcAR98yQ9

[Sergej Djuranovic @DjuranovicLab]

Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact us for further instructions if needed. @IsraelF96135088 you'll like this one.
A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies https://t.co/qqJA6y2ysU

[nature @Nature]

How ribosomes shape protein folding https://t.co/ETDlWdTAb6