Michaelis Lab

single-molecule studies, FRET, super-resolution microscopy

[Nature Communications @NatureComms]

Binary-FRET for monitoring two FRET reactions, one encoded in the fluorescence lifetime of the donor, the second encoded in its anisotropy #FRET @NIAAAnews

https://t.co/TaH6GrFYuW

[jens michaelis @michaelis_jens]

Open PhD student positions. Interested in single-molecule live-cell imaging and super-resolution microscopy approaches? Interdisciplinary project with applications in tuberculosis and drug delivery within a large collaborative initiate @CRC1279. More info contact me or apply now.

[Nature Communications @NatureComms]

Scientists use single molecule tracking and find a stress-induced reduction in TDP-43 mobility in the cytoplasm, potentially relevant for TDP-43 3 aggregation. @danzer_karin, @michaelis_jens

https://t.co/5MUHzNBlkJ

[Michaelis Lab @Michaelis_Lab]

Excited to share our latest publication 'Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level'

Check it out👇👇👇

https://t.co/ljCCH33czk

[Michaelis Lab @Michaelis_Lab]

Our warmest congratulations to @ThomasVomhof on achieving his PhD👨‍🎓💐! We are grateful for setting such a great example @BiophysicsUlm for the rest of us!!!

[Michaelis Lab @Michaelis_Lab]

@kuchler_oliver Congratulation on becoming a PhD holder!!! We wish you all the best in your future career! @BiophysicsUlm

[Michaelis Lab @Michaelis_Lab]

You nailed it! Congratulations doctor Lisa! Best Wishes for the future! @BiophysicsUlm @MichaelisLab

[jens michaelis @michaelis_jens]

Application period for Biophysics Master @UlmUniversity has started. Apply now to enter an international and interdisciplinary study program with state of the art lab courses and loads of hands on experience, infos at https://t.co/2qdZhYC86H

[Michaelis Lab @Michaelis_Lab]

Congratulations Uwe on completing your PhD! @BiophysicsUlm @Michaelis_Lab

[Michaelis Lab @Michaelis_Lab]

Single molecule tracking of TDP-43 reveals slow down of mobility in the cytoplasm and nucleus👇👇👇 @danzer_karin @GebhardtLab @BiophysicsUlm

[jens michaelis @michaelis_jens]

Do you know how aggregation of ALS related TDP-43 starts? We find mobility loss after stress throughout the cytoplasm and nucleus using live-cell #SingleMolecule tracking and #Superresolution mobility mapping. Great collaboration with @danzer_karin. https://t.co/Mc3CTjyq7p

[Michaelis Lab @Michaelis_Lab]

An exciting study using single molecule FRET! Check it out! @BiophysicsUlm #PARP1 #Dynamics #PARPi #smFRET

[jens michaelis @michaelis_jens]

Are you interested how PARP-1 recognises DNA lesions and how dynamics are influenced by clinically used PARP-1 inhibitors? Great collaboration with Sebastian Eustermann: Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level https://t.co/CFxX06crEj

[jens michaelis @michaelis_jens]

Are you interested how PARP-1 recognises DNA lesions and how dynamics are influenced by clinically used PARP-1 inhibitors? Great collaboration with Sebastian Eustermann: Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level https://t.co/CFxX06crEj

[Anders Barth @anders_barth]

This preprint is for the #smFRET people out there. To identify dynamics, we like to put reference lines on the histograms of the molecule-wise FRET efficiency and donor lifetime… yet we never quite explain them in detail. So we wrote a paper on it. https://t.co/uZfqPmW4ub

[Biophysics Ulm @BiophysicsUlm]

Congratulations Achim with successful completion of your PhD! We wish you all the best in your future career! @GebhardtLab @BiophysicsUlm

[Nature Methods @naturemethods]

Happy to share Paint server and homology optimization pipeline (PaintSHOP), an interactive platform for the design of FISH experiments. PaintSHOP democratizes and standardizes designing complex probe sets for the oligo FISH community. https://t.co/O4h8k5p7T4

[Bastian Beitzinger @b_beitzinger]

Check out our work on antimicrobial peptide delivery via mesoporous silica nanoparticles against intracellular Mtb recently published in Advanced Healthcare Materials. Many thanks to our great collaborators from @crc1279! @Michaelis_Lab @AdvSciNews https://t.co/JkAiKaR168

[Michaelis Lab @Michaelis_Lab]

We are happy to be part of this study. Great collaboration! @robert_ife @Michaelis_Lab

[Robert Schneider @robert_ife]

Another metabolite regulating chromatin and transcription – we cracked the mechanism of action behind histone succinylation ! - excited to share one of our latest papers from https://t.co/lEKEDnmTJJ @EMBOReports @michaelis_jens
https://t.co/oJpyDCSHm1

[EitanLernerLab @eitan_lerner]

Excellent work from the Craggs (@Craggs_Lab ) & Ebenstein (@hagenom) groups - Multi-modal Single-molecule Imaging with Continuously Controlled Spectral-resolution (CoCoS) Microscopy https://t.co/yu1hSn7JNr

[Fernando Stefani Lab @FerStefaniLab]

1/6 We are delighted to present our work on pulsed interleaved MINFLUX. p-MINFLUX is a simplified implementation of the MINFLUX concept that provides 1-2 nm localization precision and access to lifetime information! Great collaboration with @TinnefeldLab!

https://t.co/qBaPH9RfWw

[LipfertLab @LipfertLab]

Hows does the coronavirus attach to your cells? Our new magnetic tweezers assay shows how its Spike protein binds stably to the human receptor ACE2 - even under external forces. Very excited to share the preprint! https://t.co/XWxaSZqY9P