David Michonneau

MD, PhD, hematologist @HopSaintLouis Professor of hematology @univ_paris_cite INSERM U1342 @Leukemia_Inst

[Science Translational Medicine @ScienceTM]

Scientists uncover pre-treatment signatures in monocytes, myeloid cells, and T cells that predict corticosteroid resistance in patients with acute #GVHD, hinting steroid resistance is an intrinsic property of immune cells. @MichonneauDavid @Leukemia_Inst https://t.co/9t8KBy0962

[David Michonneau @MichonneauDavid]

@CryoStem @Inserm @Institut_IRSL @HopSaintLouis @APHP @Leukemia_Inst @siric @universiteparis @cryostem_FR 👏 I would like to thank all our collaborators, especially Sophie Le Grand for her outstanding scientific work and @nivallet, and all our funder @FLeucemieEspoir @fdmaladiesrares @HPNFranceAM Fonds de dotation CSL behring Siric InSitu and InIdEx immuno-oncology @univ_paris_cite

[David Michonneau @MichonneauDavid]

New in @ScienceMagazine

🧬 Thrilled to share our last paper

Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset | Science Translational Medicine https://t.co/c4SYwYhm6I

[David Michonneau @MichonneauDavid]

@CryoStem This work is the result of a truly collaborative effort between @inserm @Institut_IRSL @HopSaintLouis @APHP @Leukemia_Inst @Siric InSitu, @universiteparis @cryostem_FR

[David Michonneau @MichonneauDavid]

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity | Science https://t.co/gx2NTBmYkw

[Waggoner Lab @LabWaggoner]

Multiplexed imaging of acute GVHD gastrointestinal biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology
https://t.co/ZPit3SfCah @leeat_keren @WeizmannScience

[David Michonneau @MichonneauDavid]

Happy to share our last article in collaboration with @nofar_azulay and @leeat_keren @WeizmannScience in @ScienceTM A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology https://t.co/OYWX0ijUtV

[David Michonneau @MichonneauDavid]

https://t.co/57337lAgKC

[David Michonneau @MichonneauDavid]

Diet outperforms microbial transplant to drive microbiome recovery in mice | Nature https://t.co/ftCWbGb7i6

[David Michonneau @MichonneauDavid]

Great collaboration with Robert Zeiser ⁦@Uniklinik_Fr⁩ ⁦@Leukemia_Inst⁩ ⁦@univ_paris_cite⁩ Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey | Bone Marrow Transplantation https://t.co/klSjbywQqJ

[David Michonneau @MichonneauDavid]

AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling https://t.co/OeuXq10Bcp

[David Michonneau @MichonneauDavid]

@SFGM_TC @APHP @HopSaintLouis @Leukemia_Inst @univ_paris_cite https://t.co/KHzA2NSgxO

[David Michonneau @MichonneauDavid]

Happy to share our last paper, published with @SpringerNature in @BMTjournal, about the French experience with belumosudil in the treatment of steroid-resistant cGvHD. Best ORR 57.4% including 14.7% of CR in patients who previously received at least 2 LOT
https://t.co/6ismHZTNzV

[David Michonneau @MichonneauDavid]

Thanks to all collaborators, French centers of #alloHSCT and to @SFGM_TC. @APHP @HopSaintLouis @Leukemia_Inst @univ_paris_cite

[GvHD Hub @gvhd_hub]

CONGRESS | #EBMT25 | POSTER
David Michonneau @MichonneauDavid, @HopSaintLouis @univ_paris_cite shares findings from a real-world retrospective analysis of belumosudil in treatment of #cGvHD. The results were consistent with the findings from the ROCKSTAR trial with no new safety signals identified.
Follow our live feed for more updates: https://t.co/UVTsp4Eb1q
#GvHD #MedicalCongress @TheEBMT