Michael Landau

Pathologist with Panache #GIPATH #cytology #pathology

[Michael Landau @MikeLandauMD]

@CytoJC My pleasure!

[Michael Landau @MikeLandauMD]

@CytoJC The case u refer to was the 1 AcCC that was neg for NR4A3 IHC on both FNA & resection. We don't have a definite explanation for why. It was also neg for MSANTD3 FISH. We hypothesized that maybe NR4A2 was involved in this case - but we didn't stain for it so did not prove it.

[Michael Landau @MikeLandauMD]

@CytoJC It certainly would be nice, since IHC is cheaper & faster. But NR4A3 works better than other IHC stains for H&N tumors we have tried in our lab. For instance, we have not found great success w/ PLAG1 & HMGA2 IHC.

[Michael Landau @MikeLandauMD]

@CytoJC Oddly, the FNA of the primary showed only 1+ positivity (weak staining) while the LN met showed 3+ positivity (strong staining). I don't remember if there were low-grade areas in the primary resection - would have to check.

[Michael Landau @MikeLandauMD]

@CytoJC We wanted to give DOG1 a fighting chance, so we scored it using 2 different thresholds (any memb/cytopl staining vs. circumferential). Since it shows different patterns, we weren't sure which threshold was best and assessed both.

[Michael Landau @MikeLandauMD]

@VarshaManuchaMD @CytoJC I would add that normal acini & AcCC cells can be intermixed, so the tumor cells can be missed if u are only relying on DOG1. The apical or circumferential staining can be weak and not obvious.

[Michael Landau @MikeLandauMD]

@CytoJC It's possible - I haven't seen those abstracts yet.

[Michael Landau @MikeLandauMD]

@CytoJC Our pet dwarf hamster named Mochi:

[Michael Landau @MikeLandauMD]

Check out our review on AI in cytology in the ASC Journal! https://t.co/IjPl9pYQTf #asc #cytology #ai

[Michael Landau @MikeLandauMD]

Check out our review on AI in Cytopathology in the @JASCJOURNAL

[Michael Landau @MikeLandauMD]

Yikes! https://t.co/bBSUrVS5KQ

[Venk Murthy MD PhD @venkmurthy]

Interesting commentary on lowering p-value threshholds to 0.005 & alternative approaches from Prof. John Ioannidis (the only person who scares @ProfDFrancis).

https://t.co/zvnIdNYHyG

@bnallamo @JeremySussman @RogueRad @f2harrell @StatModeling @AkbarWaljee @jzayanian @iwashyna

[Michael Landau @MikeLandauMD]

@smlungpathguy @Konzult_ @BinXu16 @mreyesm @VijayPatho @kriyer68 @Chucktowndoc @DrjohninNE @sam_albadri @lara_pijuan @MayoClinicPath @Sara_Jiang So bad!

[Michael Landau @MikeLandauMD]

@RogueRad Why not

[Aatur Singhi, MD PhD @PancPathologist]

The distinction between G3 #PancreaticNeuroendocrine Tumors & Carcinomas can be challenging. Can you tell the difference? #GIPath #Pathology

[Michael Landau @MikeLandauMD]

@RhondaYantiss @DrJoannaGibson First diagnosis?

[Aatur Singhi, MD PhD @PancPathologist]

Many thanks to @PanCANPgh, @PanCAN and @UPMCnews, Striving to End #PancreaticCancer #PancreaticCysts https://t.co/a5uwK4m72Q

[Siddhartha Mukherjee @DrSidMukherjee]

My first "On Medicine" column for the Times; will appear monthly exploring the frontiers of medicine and science .. https://t.co/fJi6hNcO2K

[Michael Landau @MikeLandauMD]

@gipath1 Absolutely

[Michael Landau @MikeLandauMD]

@RogueRad People take advice from twitter?