We introduce a new disulfide bond metathesis strategy using Koser's reagent as a radical initiator, enabling biocompatible, bidirectional reactions under mild conditions, with potential in drug development, protein engineering, and biomedical applications.
https://t.co/hmafgDyy8V
Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean@JacobGeri1@JamesO760
David MacMillan in @elpaisinenglish: “The problem we face isn’t that science is becoming more complex, it’s that scientists are struggling to explain what we do and why it’s important. If we don’t think about how to communicate, we lose everyone.”
Read: https://t.co/PyF28Homob
Now out from the @MacMillan_Lab in @nchembio: “µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.”
Congratulations Roderick, Steve, Sean, and Dave on this fine work.
Paper here: https://t.co/8Oza8GJdxP
David MacMillan @MacMillan_Lab spoke last week to teachers from 30 countries at the Annual @Nobel Teacher Summit in Stockholm, where he underscored the importance of teachers to his science.
(Shout out to Miss McKean @NewStevenstonPr.)
We present an amine-differentiating amide synthesis using an sp-carbon-activated ester. The bulky TIPS group prevents unwanted reactions while allowing for easy removal, facilitating post-modifications like click reactions and peptide-drug conjugations.
https://t.co/oJAAklMxEE
Our new metal-free approach enables 1,3-addition of amines to α,β-unsaturated aldehydes without directing groups. By using iodine and an oxidant, it yields unsaturated α-amino acetals, crucial for synthesizing bioactive molecules and pharmaceuticals.
https://t.co/JG8fqSJETH
Inspired by nature, we used water as both solvent and reagent in developing a metal-free deuteration catalyzed by triaryl carbenium ion-pair. This approach offers a sustainable alternative to traditional H/D exchange, addressing metal-related challenges.
https://t.co/yEvoJh6nRN
Achieve selective and efficient electrocatalytic benzylic C−H oxidation in air using the [Ph3C]+[B(C6F5)4]− ion-pair. Our method avoids overoxidation and the use of expensive oxidants while being tolerant of diverse functional groups. https://t.co/ssgQA3wMuR
Sometimes I miss my PhD time. I got the courage and resources to try random things, and enjoyed any new knowledge even sometimes I was wrong originally. Life is not about publication or positive results, but new understanding/banter/hotpot/BBQ/Chinese restaurant that's cash only.
A new era for peptide synthesis using unprotected amino acids is coming! A phenomenal work by Zhao Junfeng, pioneering atom economic and pot economic peptide synthesis.
https://t.co/3HeboZalwC
17 years in the making..
We are super excited to finally achieve alcohol-alcohol cross-coupling enabled by the powerful SH2 radical sorting! Great work Jerry, Nick, Jay, James, Colin and Robert. Big shout out to our collaborator Jesus from Janssen Spain.
https://t.co/PRi5bjqkJL
Congratulations to the @MacMillan_Lab on their paper out today in @Nature: “Alkene dialkylation by triple radical sorting.”
Well done Johnny, Will, and Dave!
Story here: https://t.co/HVqNovXpsO
Making Waves in Green Chemistry: Our team's relentless pursuit over 30 years to develop water-compatible reactions culminates in our latest account. Join us in thanking our incredible team and celebrating this milestone towards a more sustainable future.
https://t.co/omAoTbO9pf
Congratulations to Ting Zhang and @jzhhua for developing a rare earth metal catalyzed aerobic dehydrogenation of N-heterocycles!
https://t.co/MTZGT2IRfE
Congratulations to Wubing Zeng and Peizhong Xie for developing an organophotoredox-catalyzed intermolecular formal Grob fragmentation of cyclic alcohols with activated allylic acetates!
https://t.co/gGIu0g2DZC
Congratulations to Xiaoyu Zhang and Peizhong Xie for developing an organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates!
https://t.co/WnJRE6EO0T
Check out the latest Green Chemistry Articles of Interest to the Pharmaceutical Industry, a biannual compilation of summaries by @ACSGCI and @OPRD_ACS on recent literature with alignment to the principles of Green Chemistry and Green Engineering https://t.co/w0Qt6HC6GG