mina

ucsd ‘21

[Valentin F. Cracan @VFCracan]

Mechanistic studies of redox dysfunction remain challenging due to limited strategies that can perturb redox metabolism in various cellular or organismal backgrounds.

Most studies involving impaired redox metabolism have focused on oxidative stress; consequently, less is known about the settings where there is an overabundance of NADH reducing equivalents also known as reductive stress.

In an article in Nature Chemical Biology @nchembio today, we are introducing a new genetically encoded tool to increase cellular NADH/NAD+ ratio which we named EcSTH. Using EcSTH, we determined that metabolic and transcriptomic signatures of the NADH reductive stress (aka high NADH/NAD+ ratio) are cellular background specific. For example, we show that, under the NADH reductive stress, non-oxidative PPP, purine biosynthesis and GDF15 metabokine levels are upregulated. Another interesting implication of our work is that reductive stress can also result in the accumulation of noncanonical sugar phosphates, which are known to be toxic. We anticipate that EcSTH tool will be useful for investigating redox metabolism in various cellular and organismal contexts and disease states, including aging-associated metabolic changes! @XingxiuPan @MinaLorrain @saraviolante @russpgoodman

Check out the full version of the paper below for details: https://t.co/Rho0R0X9gk

or

https://t.co/Vy0oN192SY

Supported by: @Scintillon @scrippsresearch @NIGMS @NIDDKgov

[mina @MinaLorrain]

@krnnguyen_ ice leggero is rly good and I’m trying the double espresso dolce rn and like it a lot!! doppio isn’t bad either but I miss the leggero 😭

[Valentin F. Cracan @VFCracan]

Excited to announce the new preprint from our lab where we introduce a new genetic tool to model NADH reductive stress (elevated NADH/NAD+ ratio) in mammalian cells @MinaLorrain Evana Abdulaziz @XingxiuPan & Justin Cross and Sara Violante @saraviolante from MSKCC. See below:

[Valentin F. Cracan @VFCracan]

We are thrilled to announce that our paper on a self-sufficient water-forming NADH oxidase from Trichomonas vaginalis is officially out at @jbiolchem https://t.co/uDuYe2Mlq2

[Shayla @shaydeofgold]

I’m here for the women who get abortions just because they want to. No explanation. If she does not want to be pregnant, that’s a good enough reason to me. I truly do not care. I’m done playing this morality game.

[mina @MinaLorrain]

@VanessaMarie73 @kiskully Bratz were and still are iconic ur just a hater

[mina @MinaLorrain]

@kiskully She do be paintin

[ki @decayingki]

some art i made for ur feed <3

[Maya Angelique👑 @moneyymaya]

Bruh she’s the coolest kid ever lol

[pisces loser @RyleeGiles]

22 bitches 💙

[Nicole Lee Schroeder, PhD @Nicole_Lee_Sch]

When I was 16 my first job was at McDonald's. Now I'm months away from defending my dissertation for my PhD. I've had many jobs in between - research assistant, archival assistant, editor, etc. The hardest work out of them all? That McDonalds job. 1/5

[mina @MinaLorrain]

@pchitle Free my girl she didn’t do anything wrong!

[mina @MinaLorrain]

@EleanorJEyre SO SO SO PROUD OF YOUUUUU!!!!!

[mina @MinaLorrain]

@RyleeGiles One direction 😌😌

[System Of A Down @systemofadown]

Please take a few minutes to watch our full interview to get a more intimate look and understanding into why we came together to release “Protect The Land” and “Genocidal Humanoidz”: https://t.co/9GdqjFmEaN

Help us spread the message.
@ArmeniaFund #ArtsakhStrong

[Zartonk Media @ZartonkMedia]

Cher Releases PSA Urging The United States To Take Action.

[Mollie Smith @msmith_345]

lets see if this works🙏🏼my dads paint&flooring store is suffering bc of some of the bigger companies(ex: Home Depot). its the oldest privately owned business in Westminster &he would be heartbroken if he had to close. if anyone in OC is remodeling, give him a call or pls RT(:

[Jeff Paulson @jeffpaulson78]

Mail in votes are taking so long... I swear this is what they’re doing with each vote #nevada #arizona #pennsylvania #georgia

[DWA•NESHA @Duanecia]

This is one of the most incredible pieces of research I’ve ever come across. Even better that it’s on here and digestible. Read this 👇🏾