Mitch Keylor

Chemist who enjoys golfing, skiing, food and wine, hiking, reading, and spending time with family and friends

[Mitch Keylor @MitchKeylor]

@MBTA_CR This mess has gone on for weeks now and has real consequences for riders and their families. Clean it up

[Mitch Keylor @MitchKeylor]

@MBTA_CR What is happening with the inbound train from providence? It has been parked just shy of the Mansfield station for 12 min

[Bess Kalb @bessbell]

Hello. Young kids back in school are so sick right now. Everyone with a preschooler has an entire household of sleepless viral cough snot fevers for the past two months without a fucking break. So if you know a parent going through this, be kind and gently hit them with your car.

[Mitch Keylor @MitchKeylor]

Hey @AmerChemSociety why was a virtual option to #ACSSpring2022 offered if streaming is so problematic? Will virtual attendees be reimbursed? It’s clear from the chat sections that many are experiencing these problems and the virtual format is unusable

[David Rothschild 🌻 @DavMicRot]

Mainstream media is simply unequipped, in temperament, skill, breadth of knowledge, to interview bald-faced liar like Bill Barr, and ensure their audience is more informed, not misinformed by the bald-faced lying, than before the interview. Some high-level reminders about Barr...

[Bob the Grumpy Med Chemist @med_chemist]

Why did no one tell me that Alpha Fold allowed you to declare a candidate without assay data?

This solves a huge problem for me and others in the field, where late stage assays are constantly preventing candidate nomination.

[Eric Topol @EricTopol]

How to reduce your chance of dying from Covid by 99%?
Get vaccinated and a booster.
One of the most impressive graphs I've seen for the impact of vaccination in the US pandemic
(thanks @redouad @OurWorldinData for re-plotting my makeshift graph from earlier today)

[Mitch Keylor @MitchKeylor]

@DrLCsquare Congratulations LC!

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Authors from @Merck describe the discovery of selective, brain-penetrant, and orally bioavailable LRRK2 inhibitors:
https://t.co/pYKuAtf51o

[L.-C. Campeau Ph.D. @DrLCsquare]

#MerckChemistry

[Scott Bagley @BagPhos]

intra-molecular H-bonding (IMHB) is one of those neat medchem tricks to hide polarity for better permeability, logD manipulation and enforcing a better binding configuration - nice use here by #MerckChemistry for LRRK2 inhibitors @ACSBioMed JMedChem ASAPs
https://t.co/i2Qk5jW8Rh

[Bob the Grumpy Med Chemist @med_chemist]

Bob's Med Chem Fact of the Day:

2 things that can make developing kinase inhibitors quite tough

-If disease non-oncologic, often very high bar for safety profile
-If need to penetrate CNS, unlike most known kinase inhibitors

This project dealt with both https://t.co/RD3G0u6faL

[Mitch Keylor @MitchKeylor]

Very happy to be able to share some of our work. One of the most high performing teams that I’ve had the privilege of working with! @Merck https://t.co/SU4UMhPzmW

[Chemjobber @Chemjobber]

@EricTopol @joshtpm @WhiteHouse @POTUS @kiranstacey @FT I work in the chemical manufacturing industry in the United States, servicing pharmaceutical companies on the hundreds of metric ton scale. I'm sorry to be so blunt, but you have no idea what you are talking about.

[L.-C. Campeau Ph.D. @DrLCsquare]

America's Best Employers For New Graduates 2021 —> “Pharmaceutical company Merck took the top spot in the ranking this year.”

So proud of all the new grads we hire at #MerckChemistry every year! https://t.co/Nd7FEwKCrS

[Mitch Keylor @MitchKeylor]

@boomdoneson @DaeCoe14 So frustrating haha

[Mitch Keylor @MitchKeylor]

@wmwuest @EmoryUniversity Congratulations!

[Rajeev Venkayya MD @rvenkayya]

It was good to discuss this with @HelenBranswell. Patents aren't a constraint to access. These things are:
🔹Lack of capacity at originators to support more tech transfers;
🔹Partners w/proven global vaccine manufacturing experience; and
🔹Raw material/component shortages. 1/

[Mitch Keylor @MitchKeylor]

@eugenegu Waiving patent rights does nothing to address the supply issue. In fact it does more to jeopardize it