Rodriguez-Perales Lab

Basically, Science is everywhere

[Nature Methods @naturemethods]

High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers.

https://t.co/V0tdM0vlwO

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[David R. Liu @davidrliu]

Today in @NatBiotech, we report the directed evolution of structured RNA motifs that enhance the efficiency of prime editing. Iterated high-throughput pooled screens and mutagenesis of these small RNA elements improved transient pegRNA lifetime.
https://t.co/ZiytYXicaJ
1/11

[Patrick Hsu @pdhsu]

Thrilled to share I've started at @Stanford's Department of Pathology (@StanfordPath) in addition to @ArcInstitute. Looking forward to a shorter commute after 5 years at @BerkeleyBioE and embarking on daring new projects

We're recruiting multiple postdocs and technical staff👇

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

細胞内で免疫反応を抑制した長鎖DNAを使って、大規模なゲノム編集を可能にしたという論文。Nature。

https://t.co/3iGuBRbM2k

[Nate Krah @N8Krah]

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

[ElowitzLab @ElowitzLab]

Just out: our forward-looking essay on mRNA “delivery cells”—engineered cells that could locally manufacture mRNA at disease sites within the body and transfer it to target cells in extracellular vesicles.

[Takashi Akera @TakashiAkeraLab]

🚨Please repost!! 🧬We are hiring POSTDOC now!! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬

[GENYO @genyo_pts]

🥼Junior Group Leader required to lead a new group in areas such as human genomics, cancer, aging, and advanced therapies.

ℹ️Full requirements and details in the call for applications: https://t.co/1091robQdZ

#ResearchJobs #JuniorGroupLeader #ScienceCareers #Granada

[CIEMAT @CIEMAT_OPI]

🧬 Un equipo del @BioInn_CIEMAT y del @CNIOStopCancer ha utilizado #CRISPR para eliminar células tumorales con oncogenes amplificados, sin dañar las sanas.

Los resultados son prometedores en modelos de neuroblastoma, cáncer de pulmón y colorrectal.

Te lo contamos todo aquí: https://t.co/bVOGuc51o4

#CIEMAT #Investigación #EdiciónGénica #Cáncer #Investigación

[Rodriguez-Perales Lab @MolCytogenLab]

Huge thanks for the support: @ContraCancerEs @FEDER @SaludISCIII

[Rodriguez-Perales Lab @MolCytogenLab]

Thrilled to share that our latest paper is out! We present a new experimental CRISPR-based strategy to target tumors with amplified oncogenes. Turning gene amplification into a vulnerability to selectively induce lethal DNA damage in cancer cells.

[Rodriguez-Perales Lab @MolCytogenLab]

In preclinical models of neuroblastoma, SCLC, and colorectal cancer, we observe reduced tumor growth, improved survival, and signs of ICD.
Link:https://t.co/yAqd90CBGJ
@CNIOStopCancer @BioInn_CIEMAT @SpringerNature @BioMedCentral

[David Sun Kong, Ph.D. @davidsunkong]

I’m excited to announce that the application for the 2026 edition of our @medialab and global synthetic biology course “How to Grow (Almost) Anything” is now open! Application link in thread 👇

[TERAV @red_terav]

Oferta de empleo en el Pediatric Cancer Center del Hospital SJD de Barcelona, para liderar y gestionar la recién establecida Unidad de Citometría. Especialista en Citómica, infórmate en: https://t.co/fseAL6YTPt

[Rodriguez-Perales Lab @MolCytogenLab]

@crisprscan Great lab and better mentor. Do not hesitate to join them 👍🏻

[Rui Benedito @RuiBenedito_]

The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👇 https://t.co/n1m7uWjB3d

[Marisol Soengas @msmelanoma]

Miraaaad… os contamos pronto cómo desde @CNIOStopCancer y The Pink Force Foundation @R2KT_Droid vamos a llevar sonrisas a niños y niñas con cáncer, y a reivindicar la importancia de la investigación en oncología pediátrica!
Ilusionante 👏

[Rodriguez-Perales Lab @MolCytogenLab]

@PauFerrol Amazing job. Probably it wouldn’t be the same without your “bit”. Congratulations to all people involved. 😉👍🏻

[Children's Hospital @ChildrensPhila]

CHOP & @PennMedicine have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.

Learn more about KJ & the future of personalized medicine: https://t.co/A9DTcNmxrR.