Mukherjee Lab

Our lab is using Legionella pneumophila as a tool to gain insights into basic mammalian cell-biological processes.
@UCSF

[Mukherjee Lab @Mukherjee_Lab]

A wonderful collaborative effort with Peter Walter @UCSF @stephenfloor @Lan_Wang_ @KroganLab @dlswaney led us to discover that Legionella toxin SidI possesses a tRNA-like shape and glycosylates the translation machinery to induce ribotoxic stress https://t.co/Dnhjeu6vy5

[Mukherjee Lab @Mukherjee_Lab]

@MattooLab @alisha_referda @StressCell @PurdueScience @PurdueLifeSci Congrats, Seema!

[Joe Bondy-Denomy @joeBondyDenomy]

The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF!
https://t.co/Gccrtpl8ym

[Mukherjee Lab @Mukherjee_Lab]

@FelixHorns Congratulations, Felix! Wishing you all the best!

[Mukherjee Lab @Mukherjee_Lab]

@PrakashLab Really amazing! Congrats!

[PrakashLab @PrakashLab]

A surprise gift of « new curve crease origami » we call Lacrygami brought to us by a single cell (this is the first example of origami in a single cell)!! Will write a longer thread shortly describing our journey to discovery - in mean time, enjoy this beautiful cell.

[Mukherjee Lab @Mukherjee_Lab]

@ankitaghoshal9 Thank you. We are looking for postdocs, and you are welcome to apply! :)

[Mukherjee Lab @Mukherjee_Lab]

@MattooLab Thanks Seema for the kind words!

[Mukherjee Lab @Mukherjee_Lab]

We are excited to report our latest finding that Legionella creates a unique niche that is independent of the host ER network.

[bioRxiv Cell Biology @biorxiv_cellbio]

Legionella uses host Rab GTPases and BAP31 to create a unique ER niche https://t.co/J0JFJ3roT4 #biorxiv_cellbio

[Eric Betzig @Eric_Betzig]

#FluorescenceFriday #cellbiology #bioart
The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute:
Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.
https://t.co/H9kU2qeuPb

[American Society for Cell Biology @ASCBiology]

NEW MBoC Call for Papers: Special Issue on Cell Biology of Infection!

Submit an article by Oct 30 to be considered by lead editors:

Nihal Altan-Bonnet, @nih_nhlbi
@Mukherjee_Lab, @UCSF

Learn more and submit: https://t.co/ygEJuzybC6

[American Society for Cell Biology @ASCBiology]

Exciting update!

Starting December 2, 2023, all ASCB member submissions to MBoC are ensured a thorough peer review. Simply ensure the corresponding author is an ASCB member to qualify.

[Mukherjee Lab @Mukherjee_Lab]

@PTurnbaugh @UCSF Thank you, Peter! It was a lot of fun!

[Mukherjee Lab @Mukherjee_Lab]

@SonashreeS @NatureCellBio Thank you!

[Mukherjee Lab @Mukherjee_Lab]

Thank you @NatureCellBio for accepting this work! We are absolutely thrilled!

[Nature Cell Biology @NatureCellBio]

☕️NEW: @Mukherjee_Lab, Walter & co show that the secreted #Legionella protein SidI is a #tRNA mimic and #glycosyltransferase that inhibits #HostCell translation by inducing #ribosome collisions & #ribotoxic stress response. @UCSF
https://t.co/OtyIFjEMlt
https://t.co/F3JmCg29NM

[Mukherjee Lab @Mukherjee_Lab]

@Nick_E_Scott @NatureCellBio Thanks for the tip! We will look into it.

[Mukherjee Lab @Mukherjee_Lab]

@GuonHuang @NatureCellBio Thank you!

[Mukherjee Lab @Mukherjee_Lab]

@JohnGrossSF @NatureCellBio Thank you!

[Mukherjee Lab @Mukherjee_Lab]

@gekaragoz @NatureCellBio Thank you!

[Mukherjee Lab @Mukherjee_Lab]

@Nick_E_Scott @NatureCellBio Thank you, Nichollas. We couldnt detect mannosylation in any of the Ser/Thr residues. You may be exactly right, and it could be an unusual amino acid that is gettting modified. We are on it! :)

[Mukherjee Lab @Mukherjee_Lab]

@NadineSamaraLab @NatureCellBio Thank you!