MyeloidNetwork

The Myeloid Network connects researchers worldwide to promote communication and advancement of research and medicine in the field of myeloid cell biology.

[MyeloidNetwork @MyeloidNetwork]

Please join us on May 14th (next Thursday) on Zoom for this month's Myeloid Network seminar featuring Dr. Lawrence Fong @fredhutch for his talk titled, "Myeloid determinants of response to cancer immunotherapy." Info and zoom link: https://t.co/MTWI3u5kjt

[MyeloidNetwork @MyeloidNetwork]

Join us on April 9th (This Thursday!) on Zoom for this month's Myeloid Network seminar featuring Dr. Lisa Butterfield for her talk titled, Human Dendritic Cell Vaccines and Cancer-induced Dysfunction. Info and zoom link: https://t.co/MTWI3u5kjt

@MyeloidNetwork

[MyeloidNetwork @MyeloidNetwork]

Join us on April 9th (Next Thursday!) on Zoom for this month's Myeloid Network seminar featuring Dr. Lisa Butterfield for her talk titled, Human Dendritic Cell Vaccines and Cancer-induced Dysfunction. Info and zoom link: https://t.co/MTWI3u4MtV

@MyeloidNetwork

[MyeloidNetwork @MyeloidNetwork]

Join us on March 12th (This Thursday!) on Zoom for this month's Myeloid Network seminar featuring Dmitry Gabrilovich @AstraZeneca for his talk titled, Kill or not to Kill: how tumor neutrophils can neutralize T cells.

Info and zoom link: https://t.co/MTWI3u5kjt
@MyeloidNetwork

[Jennifer Guerriero, PhD @JennGuerriero]

Join us THIS Thursday (Feb 12 @11am EST) on zoom for this month's Myeloid Network seminar, featuring 🌟super star 🌟new @YaleMed @YaleCancer faculty @Nelson_LaMarche a former @MiriamMerad lab member for his talk:
Targeting the myeloid developmental spectrum in cancer: from the bone marrow to the tumor (to the clinic) and back again.
Info and zoom link: https://t.co/39FUBo1hmC
@MyeloidNetwork

[MyeloidNetwork @MyeloidNetwork]

Join us this Thursday for a fantastic Myeloid Network Seminar!

[Jennifer Guerriero, PhD @JennGuerriero]

Join us this Thursday, Jan. 8 @11am EST for the first Myeloid Network Seminar of 2026! Dr. Douglas Hanahan will present on Disrupting IL-1-driven systemic immunosuppression by neutrophils restores vaccine efficacy in HPV16+ tumors. Join us! https://t.co/NoUcUF6swn

[MyeloidNetwork @MyeloidNetwork]

Join us this Thursday (Oct 9) for The Myeloid Network Seminar at 11am EST / 8am PST, via zoom, featuring @NanZhangWistar from the @TheWistar, who will present "Leveraging myeloid cell activation in metastatic ovarian cancer".
Zoom link and more info: https://t.co/CboVfKy5UG

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[MyeloidNetwork @MyeloidNetwork]

👏🏼👏🏼Let’s be mindful of how we define macrophages in tumors. They are not M1 or M2. In order to move the field forward we need to use better description of this highly heterogeneous population of cells.

[Jennifer Guerriero, PhD @JennGuerriero]

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.

[Yan Leyfman, MD @YLeyfman]

🧠💥 Can macrophages revolutionize cancer immunotherapy?

Macrophages naturally infiltrate tumors, reshape the TME, phagocytose cancer cells 🦠, and activate T cells ⚔️—making them powerful tools for next-gen therapy.

🚀 Enter CAR-Ms: Chimeric Antigen Receptor–engineered Macrophages.

🔬 In early trials and preclinical studies, CAR-Ms:
✅ Kill tumors via phagocytosis
✅ Modulate immunosuppressive TMEs
✅ Induce endogenous anti-tumor T cell responses
✅ Show low CRS risk vs CAR-T cells
✅ Infiltrate solid tumors more efficiently than CAR-T/NK cells
🧪 Key strategies boosting efficacy:
Anti-CD47 ("don’t eat me" blockade)
Anti-PD-1 combination
Proinflammatory signaling (e.g. IL-12, IFN-γ)
In vivo delivery via LNPs or hydrogel platforms

💡 CAR-Ms may solve CAR-T’s biggest limitations:
— 🚧 Toxicity
— 💰 Cost
— 💉 Solid tumor resistance

🎯 Future focus:
Safer vectors (CRISPR > lentivirus)
Off-the-shelf or in vivo platforms

Targeting oncogenic drivers, not just surface antigens
📚 Read more about how CAR-Ms may reshape the future of immunotherapy. https://t.co/GaFe011AMN

#CARMacrophage #CancerImmunotherapy #CellTherapy #OncologyResearch #TumorMicroenvironment #CRISPR #ImmunoOncology #MacrophageTherapy #CAR_T #SolidTumors #NextGenTherapies

[MyeloidNetwork @MyeloidNetwork]

Join us for the April Myeloid Network Seminar featuring @LeilaAkkari1 from the @NKI_nl.
"Unveiling Myeloid Cell Diversity in the Brain Cancer Ecosystem"
April 10, 2025: 11:00 AM (ET) / 8:00 AM (PT) / 15:00 UTC.
Join us! https://t.co/7JEZBUx7Ue

[Miriam Merad, MD, PhD @MiriamMerad]

Few open spots left for our FREE online International 🎓 Immunoschool 🎓! Join leading immunologists Monday, March 10—for an exclusive deep dive into the cutting-edge research behind the most successful immunotherapies and what's on the horizon.

SIGN UP: https://t.co/3MBxbrdvM7

[MyeloidNetwork @MyeloidNetwork]

Join us Thursday, March 13, 2025 8AM PST / 11AM EST for the monthly #MyeloidNetwork seminar featuring Dr. Erika Pearce @hopkinskimmel "A Polyamine-mediated Posttranslational Modification Required for Macrophage Tissue Residency".
Info and Zoom link: https://t.co/Q3zasWVECs

[MyeloidNetwork @MyeloidNetwork]

The Myeloid Network is proud to promote @KeystoneSymp #MyeloidCells: Roles in Different Tissue #Microenvironment, this March! Join us in just one month to explore emerging research in Hannover! https://t.co/DDyYLx0KI8 #KSMyeloid25

[MyeloidNetwork @MyeloidNetwork]

TODAY is the deadline for the @KeystoneSymp #MyeloidCells: Roles in Different Tissue #Microenvironment, this March in Hannover! See scholarship, abstract and discount reg dates: https://t.co/DDyYLx0KI8 #KSMyeloid25

[MyeloidNetwork @MyeloidNetwork]

Join us this Thursday for the monthly #MyeloidNetwork seminar featuring Dr. De'Broski Herbert's talk on "Myeloid-derived IL-33 drives itchy immunity".
February 13, 2025, 8AM PST / 11AM EST
Info and Zoom link: https://t.co/Q3zasWVECs

[MyeloidNetwork @MyeloidNetwork]

The @MyeloidNetwork is excited to work @KeystoneSymp on their upcoming meeting on #MyeloidCells: Roles in Different Tissue #Microenvironment, this October! Join us to explore emerging research in Hannover! https://t.co/DDyYLx0KI8 #KSMyeloid25

[MyeloidNetwork @MyeloidNetwork]

One week away! February 2-5, 2025: Explore emerging research with field leaders @KeystoneSymp Innate Immune Memory: Mechanisms and Consequences, this February in Vancouver! https://t.co/axatTBjDdt #KSInnateImmune25

[MyeloidNetwork @MyeloidNetwork]

Deadlines are approaching for @KeystoneSymp #MyeloidCells: Roles in Different Tissue #Microenvironment, this March in Hannover! Poster Abstract Deadline: February 10, 2025: https://t.co/DDyYLx1ixG #KSMyeloid25

[MyeloidNetwork @MyeloidNetwork]

It's not too late to join this incredible meeting. Explore emerging research with field leaders @KeystoneSymp Innate Immune Memory: Mechanisms and Consequences, this February 2025 in Vancouver! https://t.co/axatTBjDdt #KSInnateImmune25