Nitin Joshi

Asst. Professor @Harvardmed and @BrighamAnes

[Mass General Brigham Research @MGBResearchNews]

Researchers develop “smart” nanoparticles to deliver targeted gene therapy in osteoarthritis.

Read more from @MassGenBrigham @NJoshiBWH and colleagues: https://t.co/zwM5daJFUy @NatureNano

[Nitin Joshi @NJoshiBWH]

@MassGenBrigham @MGBResearchNews @harvardmed
#NatureNanotechnology #GeneTherapy #mRNA
#Nanomedicine #Osteoarthritis

[Nitin Joshi @NJoshiBWH]

Our new paper is out in @NatureNano
We describe a non-viral gene delivery platform that delivers mRNA precisely to damaged cartilage in osteoarthritis and self-regulates targeting and expression as disease severity increases.
https://t.co/s906T7KI5L
https://t.co/XsvSgss32B

[Nitin Joshi @NJoshiBWH]

Huge congratulations to @DewaniMahima and @jgao_umass for leading this work. Grateful to our collaborators Li Zeng, Anjali Mamidwar, @MrJeffKarp and the rest of the team who made this possible.
Excited about what this means for precision gene therapies in degenerative diseases!

[Nitin Joshi @NJoshiBWH]

@zongmin_zhao @NatureComms Congratulations Zongmin!

[Nitin Joshi @NJoshiBWH]

HUGE thanks to my collaborators @MrJeffKarp
and Joerg Ermann, and congratulations to the entire team for the tremendous work over the years. Thank you
@NIH @NIH_NIAMS @DeptofDefense @NFLPA @RheumResearch for the support.
@MassGenBrigham @BrighamWomens @harvardmed @BrighamAnes

[Nitin Joshi @NJoshiBWH]

🔥Our latest work is out in PNAS! We report a mechanically resilient hydrogel that enables sustained, localized delivery of therapies for post-traumatic osteoarthritis, without breaking down under physical activities like running! https://t.co/jXHV6GlKV3
@PNASNews

[Yizhou Dong @yizhoudonglab]

Blood–brain-barrier-crossing lipid nanoparticles (BLNPs). Wonderful academia and industry collaborations @IcahnMountSinai @biogen @OhioState! Thanks @NIGMS & @NIDAnews! Thanks @NatureMaterials editor and reviewers!

[@BMES_CMBE @BMES_CMBE]

Rising Stars 2025! @BrianAguado Haogang Cai @JunChenLab @DengYanxiang @mhhettiaratchi @LaurelHind Guosong Hong @priscilla_hwang @NJoshiBWH @IsaacLeeLab Jiahe Li @ClaudiaLoebel @mistrigr @KarinaNakayama @hadi_nia @LabRaghavan @DrRituRaman @telomerase2 @Yichun_Wang_Lab @jaweinst

[Nitin Joshi @NJoshiBWH]

@_SumanB Huge congratulations Suman!

[Nitin Joshi @NJoshiBWH]

@TheKulkarniLab Thank you so much Ashish!!

[Nitin Joshi @NJoshiBWH]

Thrilled to share our new research in Advanced Materials, describing a Pathogen Capture and Neutralizing Spray (PCANS) with potential to provide extra protection against a broad range of respiratory infections when masks and vaccines fall short. https://t.co/nmIIONPHdx

[Nitin Joshi @NJoshiBWH]

@sachinbhag Thanks so much Sachin!

[Nitin Joshi @NJoshiBWH]

Check out the press release describing our Pathogen Capture and Neutralizing Spray (PCANS) with potential to prevent a broad range of respiratory infections. @MrJeffKarp @harvardmed @BrighamWomens

https://t.co/Phd5NjTiEY

https://t.co/V4bGAK5fM9

[Nitin Joshi @NJoshiBWH]

@suman_pahal Thank you!

[Nitin Joshi @NJoshiBWH]

@pkvemula Thank you so much Praveen!!

[Nitin Joshi @NJoshiBWH]

@AnkitGangrade11 Thanks you Ankit!

[Vipin M. Vashishtha @vipintukur]

A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/

[Dana Parish @danaparish]

🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:

“The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone. 

“PCANS forms a gel, increasing its mechanical strength by a hundred times, forming a solid barrier,” said primary author John Joseph, PhD, a former postdoctoral fellow at Brigham and Women’s Hospital. “It blocked and neutralized almost 100% of all viruses and bacteria we tested, including Influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more.”

Experiments in mice showed that a single dose of the PCANS nasal spray could effectively block infection from an influenza virus (PR8) at 25 times the lethal dose. Virus levels in the lungs were reduced by >99.99%, and the inflammatory cells and cytokines in the lungs of PCANS-treated animals were normal.”

[Brigham and Women’s Research @BrighamResearch]

In a preclinical study, @NJoshiBWH, @MrJeffKarp and their collaborators have created and tested an innovative drug-free nasal spray that has the potential to be a public health tool in reducing respiratory diseases. https://t.co/JorrRcGcum