Nathalie Chami

Instructor @MountSinaiNYC interested in complex trait genetics

[Nathalie Chami @Nathalie_Chami]

Excited to share our recent publication in @NatureMedicine that identifies 205 genomic loci that disentangle #obesity from its #cardiometabolic comorbidities!
paper: https://t.co/27SOaXIrSp
press release: https://t.co/nhXp6fkHHS

[Nature Portfolio @NaturePortfolio]

Genotype-phenotype data from over 450,000 people was analyzed to find 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in @NatureMedicine. https://t.co/YDXFGrlaCs

[Nature Medicine @NatureMedicine]

Genotype-phenotype data from over 450,000 individuals was analysed to discover 205 genomic loci where an allele associated with increased adiposity was associated with a lower cardiometabolic disease risk to an individual https://t.co/IRvwKQtrwE

[Nathalie Chami @Nathalie_Chami]

@NatureMedicine The description given is for another manuscript published a month ago by our team. The new study linked is addressing why obesity affects people differently and identifies genetic subtypes of obesity that disentangle obesity from cardio-metabolic risk.

[Global Health Observ @GlobalPHObserv]

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities https://t.co/4vSe6DELlX

[Ahmed Al Askary @a_elaskary81]

2025
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
@DanielJDrucker
https://t.co/LArsUaTnJa

[Daniel J Drucker @DanielJDrucker]

A new #obesity paradox informed by #genetics 266 variants across 205 genomic loci where adiposity-increasing alleles were simultaneously associated with lower cardiometabolic risk https://t.co/QXsBlmrOrK

[Nathalie Chami @Nathalie_Chami]

@lucavalenti75 @DanielJDrucker that's coming next :)

[Kasper Lage @kasper_lage]

Extremely excited to open the registration for the 2nd Annual Variant to Function Symposium hosted by the @novonordiskfond Center @broadinstitute co-Chaired by @MelinaClaussnit. A stellar (!!) lineup of speakers & virtual+physical attendance. Please share! https://t.co/iVetU6aAJ9

[Nathalie Chami @Nathalie_Chami]

It was super exciting to be back in the UK and to present at #GRD23 earlier today on the classification of rare variants in monogenic obesity genes! Really enjoyed the discussions that followed!

[Claudia Gonzaga-Jauregui @cgonzagaj]

Natalie Charmin from Mount Sinai now presents on refining the pathogenicity of rare variants in monogenic obesity using large-scale population data from UK Biobank & implications for precision medicine Looked at the ORs and penetrance in the main 6 monogenic obesity genes. #GRD23

[Nathalie Chami @Nathalie_Chami]

Thank you @ksamocha for a great summary of my #GRD23 talk!

[Kaitlin Samocha @ksamocha]

Nathalie Charmi (@Nathalie_Chami) #GRD23: There are rare forms of obesity that are monogenic (typically early onset), which are to be distinguished from syndromic obesity.

Leptin-Melanocortin pathway regulates energy balance -> disruptions in this can lead to overeating

[Lauren Stalbow @LStalbow]

First tweet ever! Super excited to share our work on type 2 diabetes, and the interplay with rare variant risk. (I don't know if it counts if its a retweet...🤷🏼‍♀️)

[Marta Guindo @mguindom]

Congratulations to @LStalbow, Michael Preuss, @roelof_aj_smit, @Nathalie_Chami and colleagues for this work!

[Dr. Nadia Chaudhri @DrNadiaChaudhri]

Now that I have 100K followers, I want to talk about #OvarianCancer. Specifically my gritty story. The goal is awareness. I hope you find this narrative informative.

[PLOS Medicine @PLOSMedicine]

The first few articles from our Obesity Special Issue are publishing today! Ruth F Loos and colleagues investigate the penetrance of previously reported MC4R mutations at a population level using UK Biobank data .@IcahnMountSinai https://t.co/jOqWmTDMtN

[Eric Vallabh Minikel @cureffi]

Our new lab in @broadinstitute @StanleyCenter is hiring! Come join our patient-driven mission to develop drugs for prion disease in our lifetime. Seeking a postdoc https://t.co/044iRuow9h and research associate https://t.co/fXhL7LmmV1 — help us prevent neurodegeneration!

[Marc Haber مارك @MarcHaber]

We genotyped and sequenced people from Yemen to understand structure in the Near East
https://t.co/795Yr0sWmA

[prionalliance @prionalliance]

Sonia announces the collaboration between our team at @broadinstitute and @ionispharma to develop an antisense oligonucleotide (ASO) drug for prion disease https://t.co/qAYZOW5HPQ

[CANAL+ Cinéma @CanalplusCinema]

"On ne peut plus tourner le dos à ces enfants qui se débattent comme ils peuvent dans ce capharnaüm qu'est devenu le monde". Le discours poignant de Nadine Labaki, lauréate du Prix du Jury.

🎬 Vivez le 71ème #FestivalDeCannes sur myCANAL> https://t.co/Mpovrrs0az #Cannes2018