Neel Singhal

Focused on saving brain cells
Associate Editor @JAHA_AHA
Usually tireless researcher = Often tired father to 3
🇧🇷 🇮🇳 roots; 🇺🇸 🇨🇦

[Neel Singhal @Neel300]

Huge thanks to Rubinee Simmasalam, @GeriSciDoc, Michael Wilson, @samplease, and COMET study leaders including Carolyn Calfee and David Erle.

[Neel Singhal @Neel300]

🚨 Our labor-of-love pandemic project is now out in pre-print! 🚨
📖 Read it here: https://t.co/SuTVHo2uLr

With @saralahue we uncover immune signatures associated with delirium onset and resolution in COVID19 patients.
#delirium #COVID19 #NeuroICU

[Neel Singhal @Neel300]

We took advantage of the UCSF COMET study's invaluable prospectively collected PBMC RNAseq data, and rigorously defined delirium through careful chart review. It is one of the largest delirium studies with serial transcriptomic data!

Importantly, we generated fun visualizations!

[Wei Li @Wei_Li_Vision]

#GroundSquirrel develop “reversible #cataracts” during #hibernation, with their lenses quickly clearing upon waking. Using GS-#iPSC-derived lens epithelial cells, we explored the molecular mechanism behind this, pointing to a potential treatment target. https://t.co/UQxZ5lnQ2O

[H.E. Hinson, MD MCR FAAN FNCS @HollyEHinson]

Happy this paper is out in the world—we performed an external validation of IMPACT, comparing the original coefficients to updated coefficients in our patient datasets. #TBI #Neurotrauma #DataScience ⚡️📊 https://t.co/yrOgeOCTST

[Dena Dubal @DenaDubal]

Check out our lastest! A second X chromosome improves cognition in aging male and female mice. Spearheaded by Francesca Marino. https://t.co/vxMtFU1SAX

[Shahar Bracha @shaharbrr]

My PhD work on harnessing the brain parasite Toxoplasma gondii for protein delivery to the brain is out in @NatureMicrobiol !
https://t.co/tQgPEDSu7w

[Doris Wang @DorisWangLab]

Check out our case report in @JAMANeuro! Lesioning the Brain—From Serendipity to Science https://t.co/k0TZ7FVIFS

[Neel Singhal @Neel300]

Studies of stroke recovery have found that improving vascular repair can help improve neurorecovery. So in future work we hope to further understand PATJ ties to metabolism and how this pathway can be taken advantage of to enhance neurorecovery after stroke! (6/6)

[Neel Singhal @Neel300]

Sharing our Lab's first preprint led by Mengqi Zhang and in collaboration with @DengkeMa! I became interested in PATJ after it turned up in human genetic studies as associated with circadian rhythms and obesity. What we found below! (1/6)
https://t.co/kCxigH01ZP

[Neel Singhal @Neel300]

We observed induction of the worm orthologue in response to hypoxic stress in C. elegans. And in mice we observed endothelial-specific over the days and weeks following stroke (tMCAO). (5/6)

[Neel Singhal @Neel300]

Out of these we validated a few with qPCR and hope to do more work on understanding what they're doing in EVs and stroke!

[Neel Singhal @Neel300]

Our first foray into extracellular vesicles and stroke biomarkers is finally out! with @FannyElahi, Bharti Manwani, @EdAmorimMD, and many others.

https://t.co/p4du6qivPG

What we did, learned, and hope to do in the thread!

[Neel Singhal @Neel300]

We don't really know what they're all doing...but as a first step we used machine learning and other analyses to find out which ones might be particularly related to stroke.