Dinushan Kaluarachchi

Neonatologist, Associate Professor, Researcher

[Dinushan Kaluarachchi @Neo_Dr_K]

@drnicu Current strategies for treatment (tx modalities, timing, Pt selection) don't work!

[Dinushan Kaluarachchi @Neo_Dr_K]

@natetexsun @PASMeeting Wait, don’t give up the hope. What if we give it as a late treatment instead of systemic steroids (Little Lungs study). Late surf replacement and targeted steroids!!

[Dinushan Kaluarachchi @Neo_Dr_K]

Risk factors for late PH.. @WiscPediatrics experience. @doc_mcadams @ConditPaige @davidj_mcculley
https://t.co/ujUAEjyWJA

[Dinushan Kaluarachchi @Neo_Dr_K]

Our PDA trends and outcomes paper is officially out.
Grade 2 BPD is rising in more mature extremely preterm infants. It's not due to increased survival and unlikely to be ralated to PDA tx trends. #neotwitter
https://t.co/yv5DuqWuN0

[Dinushan Kaluarachchi @Neo_Dr_K]

Rules of evidence/ Laws of Inference and PDA #neotwitter
https://t.co/SBpwt44pLh

[Dinushan Kaluarachchi @Neo_Dr_K]

@BrianKingNeo Exactly! one is known to decrease BPD, fascilitate extubation, decrease CP in right babies. The other is investigational, invasive and require transfer (in our setting).

[Dinushan Kaluarachchi @Neo_Dr_K]

Piccolo vs DART in a 4wk old, 1000g, 23 weeker on MV, failed medical tx. A common question that comes up in our practice. How do you approach this? #neotwitter

[Dinushan Kaluarachchi @Neo_Dr_K]

Thanks @EBNEO for highlighting our work!

[Evidence-Based Neo @EBNEO]

NICHD NRN study investigates association between the secular decrease in treatment of PDA & trends in neonatal mortality and morbidity in infants born at 26 to 28 wks’ GA. @JPediatrics
https://t.co/wqNyG3XZSG
#neoEBM #neotwitter #EBNEOalerts

[Dinushan Kaluarachchi @Neo_Dr_K]

@BrianKingNeo @EBNEO @EpiSconroy Only 61 were excluded for NRN PDA trial (enrollment since 2018, Covid years). Included hospital as a co variate in the model (centers have multiple hospitals, only continously participating hospitals were included).

[Dinushan Kaluarachchi @Neo_Dr_K]

@BrianKingNeo @EBNEO @EpiSconroy We had a previous paper which showed no change in PDA tx in 22-25 weeks, reason why we only looked at 26-28weeks.
https://t.co/wbElSIseUl

[Dinushan Kaluarachchi @Neo_Dr_K]

@BrianKingNeo @EBNEO @EpiSconroy Thanks for sharing our work @EBNEO and great Qs @BrianKingNeo @DrAbdulRazak_MD

[Dinushan Kaluarachchi @Neo_Dr_K]

@drbretty @EBNEO @AnnaKidman3 @roseandtoby 1-2 above the PEEP on MV. Didn't change our practice.

[Dinushan Kaluarachchi @Neo_Dr_K]

@NICU_Musings These studies are important but I remain speculative (including on my own studies) that despite fancy statistics you can't assure that two groups are similar at baseline.

[Dinushan Kaluarachchi @Neo_Dr_K]

@drbretty NRS (we used in couple of our paper). Seen CPAP/ NIV as well (excludes HFNC though).

[Dinushan Kaluarachchi @Neo_Dr_K]

@TripleBadger10 @NICU_Musings @drbretty NRS (still not great!)

[Dinushan Kaluarachchi @Neo_Dr_K]

@ambaln When to switch from acute phase ventilation stratergy to chronic phase ventilation (low rate, high TV).

[Ryan McAdams @doc_mcadams]

Thrilled to share our study on using AI to enhance neonatal intubation! By automating glottic detection, we’re taking steps toward safer, more precise care for the tiniest patients. Check our paper: https://t.co/1HTGM16XpQ #AI #NeonatalCare #Innovation @NeomindAi

[Dinushan Kaluarachchi @Neo_Dr_K]

@drbretty @PlussTrial Did you seek antenatal consent (doesn’t look like it). It’s incredible your team was able to get consent in that short time frame after birth.

[Dinushan Kaluarachchi @Neo_Dr_K]

Such a great idea and a fantastic study @PlussTrial by @drbretty et al. Why it didn't work?
Should S+S be more selective? Do babies have lung inflammation that early? Would it work if use it on babies with more severe lung ds and inflammation? (eg. vs DART) #neotwitter #neoEBM

[Dinushan Kaluarachchi @Neo_Dr_K]

@NICU_Musings Don’t give up hope. Might work as a late tx in babies with higher resp illness severity and lung inflammation. Need more studies!