NextMed Health

is a cross-disciplinary program & community from across #healthtech & biomedicine reimagining the future of health & biomedicine.

[NextMed Health @NextMedHealth]

Massive thanks to everyone who came together to make https://t.co/sxi7gpRyKM 2025 a magical gathering of innovators and changemakers at the interface of technology healthcare and the human spirit.

#NextMedHealth

[Eric Topol @EricTopol]

Exercise should be prescribed, not just advised. For brain health. https://t.co/vXU6F19CgH
@NTFabiano @CorlZhou

[Daniel Kraft, MD @daniel_kraft]

What if your annual physical became a continuous physical?

Wearables + AI could turn everyday health data into insights your care team can act on, between visits.

An 80-second glimpse from my conversation with Moira Gunn on @BiotechNation 👇

[NextMed Health @NextMedHealth]

NOW: Leaky heart valves, fixed without reopening the chest. FDA just approved Abbott's Amplatzer Paraclose, the first US catheter device built to plug leaks around surgically replaced heart valves. https://t.co/fiYgnNUmLM…

NEAR: Brain stimulation that gives feedback in minutes, not months. Mayo Clinic found that deep brain stimulation for hard-to-treat epilepsy changes brain connectivity within 18 minutes. That could become a fast signal for tuning each patient's settings. https://t.co/FhEYGERgt5…

NEXT: Genetic "kill switches" that sculpt mini-organs. University of Pittsburgh scientists built self-destruct circuits that remove faulty cells as lab-grown tissue develops, which yielded more mature liver organoids. It's a step toward truer human tissue models and regenerative medicine. https://t.co/a2ujUGxux9…

@NextMedHealth • https://t.co/tFoCDLL8p2
#FutureOfHealth

[NextMed Health @NextMedHealth]

NOW / NEAR / NEXT — Oct 3

NOW: First FDA-approved treatment for MCT8 deficiency (Allan-Herndon-Dudley). Emcitate (tiratricol) lowers excess thyroid hormone when the brain’s hormone transporter is broken.
https://t.co/Me7x9PIarq

NEAR: Aging-cell “senolytic” drugs ease fatty-liver scarring. In fibrotic MASH, dasatinib + quercetin improved fibrosis in 47% vs 7% on placebo (phase 2, Nature Metabolism).
https://t.co/94zdSconPL

NEXT: Gene editing reawakens embryonic ζ-globin — a path to treat severe α-thalassemia without lifelong transfusion (Nature Genetics).
https://t.co/bivOmRvo9V

@NextMedHealth | https://t.co/tFoCDLL8p2

[Daniel Kraft, MD @daniel_kraft]

Infections were responsible for approximately 2.3M cancer cases, or about 12% of diagnoses, worldwide in 2024...

[NextMed Health @NextMedHealth]

@madukes529 NextMed Health does not prescribe medication or provide medical care.

[NextMed Health @NextMedHealth]

NOW · NEAR · NEXT

NOW: First drug for Alexander disease. FDA approved Zanvastro (zilganersen) — an RNA medicine that dials down toxic GFAP.
https://t.co/HKnqXxgE64

NEAR: Lonvo-z, Intellia’s in vivo CRISPR for HAE — rolling BLA underway; potential U.S. launch H1 2027 if approved. One shot vs lifelong prophylaxis.
https://t.co/uYFyKhNM8O

NEXT: Cellular rejuvenation enters humans. Life Bio dosed the first patient with ER-100 (OSK epigenetic reprogramming) for optic neuropathies.
https://t.co/P2wfWbrmtV

[NextMed Health @NextMedHealth]

NOW / NEAR / NEXT — the future of health & biomedicine, today.

NOW: FDA clears Onswik — a once-weekly basal insulin for adults with type 2 diabetes. Daily-level A1C control, far fewer injections.
https://t.co/QImUBjXzUs

NEAR: An AI model reading pathology + clinical data beat the standard 21-gene test at predicting early and late breast cancer recurrence. Next up: trials that could guide treatment choices.
https://t.co/meIy8JJsAu

NEXT: AI designs solid-state mRNA vaccines that kept full potency after 2+ months at body temperature — a path to fridge-free shots and microneedle patches worldwide.
https://t.co/z0gu2KeZsm

#HealthTech #FutureOfHealth

[Daniel Kraft, MD @daniel_kraft]

Is it over for human doctors?

No. Airliners can largely take off, fly, and land themselves. We still put two pilots up front, for judgment, edge cases, and trust. Same in the exam room.

My take on Washington's AI-in-medicine bet, on @NewsNation with @jessecordweber

[Eric Topol @EricTopol]

How regular exercise enhances our immune response.
A multiomic blood assessment (single-cell RNA, epigenetics, metabolites, lipids, and cells) with distinct signature for exercise vs sedentary lifestyle @ScienceAdvances
https://t.co/mcgPrLSyJ5

[Daniel Kraft, MD @daniel_kraft]

VIPR: Scientists have discovered a powerful gene-targeting system in viruses.

Billions of years old, VIPR seems to predate CRISPR, likely the evolutionary ancestor of CRISPR and may be even more effective.

From @kenjmloi, @DoudnaJennifer et al

https://t.co/FvWzKmHYzd

[Daniel Kraft, MD @daniel_kraft]

AI accelerating scientific discovery: An amplifier of human ingenuity.

-AI co-scientist: amplifying hypothesis generation, to research assistants to unlock discovery.... where everyone has a 'virtual lab' polymath AI-collaborator at their disposal... to ask bigger questions and move faster to drive & accelerate science and solutions.

Yossi Matias, @YMatias who is head of @Google Research on the acceleration of health & biomedicine

With @Johnkwerner @imaginationxyz

[Daniel Kraft, MD @daniel_kraft]

Apple Watch Series 12: new Health Sensing System samples HR every 5s all day, densifies HRV ~24×, and pairs with a Health app Longevity tab + Health Age (VO₂ max, sleep, biomarkers).

Continuous physiology → continuous prevention.

Via @Apple Newsroom

https://t.co/Ybasq5M6j9

[NextMed Health @NextMedHealth]

Incredible work by @biogerontology @InSilicoMeds @InsilicoMed et al

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

My dear friends, I am happy to report the publication of the most important paper in my life to date (we have several great papers coming out but this is very special). Tomorrow, I will present this paper for the first time at the Nature AI Healthcare in Paris and will post a longer post on this story and its broader implications for how to conduct clinical trials. Please read it and comment on it.
Many thanks to the great co-authors of the study and everyone who contributed. Many thanks to the many reviewers (friendly and unfriendly) for spending so much time and helping make it better.
Link in the comments.

[NextMed Health @NextMedHealth]

One shot. Nearly a year. Kylo-11 (siRNA) cut Lp(a) ~95–97% at 48 weeks after a single injection—Lancet / ESC.

The “untreatable” genetic CV risk factor is looking treatable, and annual dosing could fix adherence.

Cleveland Clinic / The Lancet, Aug 28
https://t.co/mU8Qu8MgdG

[NextMed Health @NextMedHealth]

Genomics reality check:
Now: we sequence fast and cheap, against a reference built from a few anonymous donors.

Near: a pangenome atlas of many diverse, telomere-to-telomere genomes.

Next: a variant means the same thing no matter whose genome it came from.

The bottleneck moved from reading to interpreting.

From @euanashley @StanfordMed

https://t.co/Z47AQTtdc0

[NextMed Health @NextMedHealth]

Alzheimer’s-like tau damage may be steered by T-cell instructions from lymph nodes outside the brain — and blocking that signal spared cognition in mice.

Neurodegeneration may be more of a systems-immune problem than we thought.

@WashU/ @NatureNeuro

https://t.co/Bxelvk8sV4

[Daniel Kraft, MD @daniel_kraft]

Late-life semaglutide extended median lifespan ~12% in aged female mice (742→834 days) and beat calorie restriction on memory & glucose

GLP-1s may be the first widely used drugs that also nudge aging biology. Human trials in older adults are next.

Feng et al. @Nature, Sep 2
https://t.co/vRrShvtaLd

[NextMed Health @NextMedHealth]

Radiologists... what do you think?
An A.I. company believes it’s the first in the world to receive regulatory approval for a breast triage tool that bypasses radiologist review for certain mammograms.

https://t.co/K5A6xeLMpR

[Daniel Kraft, MD @daniel_kraft]

OpenAI just wired ChatGPT Health into Epic (325M+ patient charts). Read-only: notes, labs, meds → pre-visit review & clinical timelines.

The EHR is becoming an AI workspace. Governance will decide if it helps or harms.

TechCrunch / OpenAI, Sept 1
https://t.co/QdrlYLaYA8