For those of you who have a terminal illness, a chronic condition, or debilitating health issue, there is new reason to have hope.
New treatments are arriving that buy more time for the next to arrive. Even for the most vicious of diseases, for example, metastatic pancreatic cancer.
The recent breakthrough, daraxonrasib, nearly doubled overall survival, 6.7 to 13.2 months, with fewer side effects than chemo. It's hard to overstate the significance of this.
In a slow world, a few months doesn't matter much. In a fast world, that could mean the difference to make it to the next life-extending therapy.
We are on a long arc of getting increasingly better at solving disease.
In 1919, Elizabeth Hughes was diagnosed with type 1 diabetes. The only treatment was a starvation diet, which she did for three years. Her weight dropped to 45 pounds at age 14.
Then insulin arrived in 1922. It allowed her to live to 73.
And recently, Sid Sijbrandij used AI and existing biotech infrastructure to fight a recurring osteosarcoma that standard medicine had given up on. Today he has no evidence of disease.
A new era for life is here. It won't appear overnight. Nor will it be all sunshine and rainbows. But we are at the inflection point where hope can dare rise as the sun for those who have been stuck in the darkness.
Episode #2509 @sircalebhammer
https://t.co/l3cMtEJbBL
Caleb is a very smart and entertaining guy giving legit financial advice to a generation who desperately needs it.
Episode is out now on @spotify and everywhere else
I experienced a huge spike in food noise when in Australia. The desire to eat continuously even though I wasn't hungry, and even full.
The seven time zone shift shocked my circadian rhythm which then altered my hunger hormones.
Leptin stopped signaling that I had enough stored energy. Ghrelin ran elevated all day instead of only before meals. Blood glucose spikes from bread and carbs (that I ate to be in family ritual) triggered emergency hunger signals in my brain
Sleep deprivation weakened my prefrontal cortex's ability to override the urge. Making me feel helpless and controlled by impulse.
That noise has been absent for years as I've dialed in habits of sleep, nutrition and exercise.
It reminded me how burdensome and debilitating the food rumination noise is. How it can feel like food is the only thing the brain can focus on, edging out all other life priorities.
I imagined traveling back in time to when I was helpless to control my eating and being presented with a miracle drug like a GLP-1 which simply flips the switch to turn off the noise.
This imagination also filled me with excitement about the future. If we can turn off food noise, what if we could turn off negative self talk, hedonism, jealously, status comparisons, catastrophizing and boredom.
What if we became effectively immune to companies hijacking our dopamine? Tricking us into self destructive habits while they profit.
I have unabashed excitement for the future because I think this is the inevitable frontier. That pessimism is being non-imaginative.
That is not to say that bad things won't happen or that we won't be challenged by the pace of change, but it is to say that conscious life is the most precious gift the galaxy has bestowed and it's our opportunity and duty to carry it forward.
Become at ease with the state of "not knowing." This takes you beyond mind because the mind is always trying to conclude and interpret. It is afraid of not knowing. So, when you can be at ease with not knowing, you have already gone beyond the mind.
As someone who's been whining like a little princess for two years about $NVDA's absurd undervaluation, it's a relief to see Wall Street finally get into the same groove. Maybe all this complaining is finally getting us somewhere.
Go $NVDA!
Taped a podcast with a large asset manager, but they scrapped the whole episode b/c they didn’t like me saying empirical evidence suggests there is no persistent single manager outperformance beyond random chance.
Apparently reality would cause “confusion” for their audience...
"You're navigating concept space, not commanding a consciousness."
This single sentence changed everything about how I interact with AI. And helps to avoid those rabbit holes . . .
10 ways to ask better — 🧵