Nicole Chambers, PhD

K99/R00 Postdoc @UF @LabMoehle @UF_Pharmacology
Neuroscience, Movement Disorders, Electrophysiology
PhD @binghamtonuniv2
Loves frogs, painting, kayaking

[Nicole Chambers, PhD @Nicholinergic]

I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work!

https://t.co/6NoFPMI9Ie

[Nicole Chambers, PhD @Nicholinergic]

In addition to investigating M5 receptor modulation, this study is the first to characterize Erasmus Ladder deficits in the 6-OHDA lesioned mouse. 6/n

[Nicole Chambers, PhD @Nicholinergic]

Excited to share my recent first author publication from my postdoc in @LabMoehle ! ⬇️⬇️⬇️ We investigated postive allosteric modulation of M5 muscarinic acetylcholine receptor in the 6-OHDA lesioned mouse model 1/n

https://t.co/FypquuvoLU

[Nicole Chambers, PhD @Nicholinergic]

Importantly, M5 positive allosteric modulation did not cause robust dyskinesia of its own, nor did it worsen L-DOPA-induced dyskinesia. Overall this suggests targeted M5 receptors modulation as a novel therapeutic target for PD. 5/n

[UF_Pharmacology @UF_Pharmacology]

We are pleased to announce Dr. Mark Moehle, Ph.D., has been awarded ASPET's 2026 Division for Neuropharmacology Early Career Award! 🎉 Please join us in congratulating Dr. Moehle for this achievement!

[UF McKnight Brain Institute @UFMBI]

180+ neuroscientists & trainees from across US & abroad discussed latest research in Alzheimer’s, Parkinson’s, ALS, dementia @UF-hosted International Research Conference on Neurodegenerative Diseases July 9-12, co-sponsored by the MBI.

Learn more: https://t.co/nLr0kzylho

[Fergil Mills @fergilmills]

Everyone's work day today #SfN

[bioRxiv Neuroscience @biorxiv_neursci]

Pathological α-Synuclein Perturbs Nuclear Integrity https://t.co/8auK7JLSR9 #biorxiv_neursci

[UF Medicine @UFMedicine]

Congratulations to our incredible @UF College of Medicine faculty recognized as outstanding or rising star researchers and mentors at the 15th Annual #UFMedResearch Celebration! Meet the winners: https://t.co/W0HLmfU8yh. #GoGators

[Nicole Chambers, PhD @Nicholinergic]

Congrats, Mark!! Well deserved!

I’m excited to be among those in @LabMoehle who are presenting research at @UFMedicine Celebration of Research tonight from 5-7.

[Mark Moehle Lab @LabMoehle]

Incredibly honored to be awarded the Rising Star Award by @UFMedicine and @UFMedResearch. This would not be possible without all the wonderful people who work in the lab and the incredible environment at @UF_Pharmacology and @UFCTRND

[Nicole Chambers, PhD @Nicholinergic]

https://t.co/mmNjLQQ5jS

[Alexandra Nelson @NelsonLabUCSF]

In this new preprint, Emily Twedell (PhD student) and colleagues identify a functional role for the inhibitory synapses between striatal projection neurons -- shaping striatal ensembles to promote healthy action selection. https://t.co/c9ED5QTlVh

[Nicole Chambers, PhD @Nicholinergic]

If you’re still here at @SfNtweets, come and see posters from @LabMoehle !

This morning Iggy presents electrophysiological and cognitive changes in the PFF model of PD and this afternoon I will present electrophysiology and behavioral data from our Gnal linked dystonia mouse.

[Nicole Chambers, PhD @Nicholinergic]

@postsamnaptic @LabMoehle Thank Sam! I hope that all is well at UNC!

[Nicole Chambers, PhD @Nicholinergic]

I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work!

https://t.co/6NoFPMI9Ie

[Nicole Chambers, PhD @Nicholinergic]

@cocacolaFroula @LabMoehle Thank you!!

[Mark Moehle Lab @LabMoehle]

Rick's dedication to curing dystonia is inspiring, and he will soon be a published expert in the disease that he and @TylersHope is dedicated to curing.

[Mark Moehle Lab @LabMoehle]

New lab preprint from the outstanding postdoc @Nicholinergic! Here we report new exciting data from a model of GNAL linked #dystonia that we have created. Most importantly, this model shows overt dystonic motor phenotypes, a first for GNAL linked dystonia (1/N).