Finally, here is the structure of GLUT4! No nanobody, no antibody — Just a 12-TM SLC by Cryo-EM! Thanks to my incredible collaborator Chuangye Yan https://t.co/mLYdYThYz1
Nieng Yan of @PrincetonMolBio conducts groundbreaking research into atomic-resolution molecular choreography, revealing the physiological and cellular processes involving membrane transport.
Watch her induction to the National Academy of Sciences: https://t.co/0HWiqFMcJF #NAS159
The unstoppable @NiengYan delivers a tour de force of ion channel structure after structure after structure…whew! She is amazing. @MembraneMeeting#Banff
First publication in the new year. Here is a free access to the full text of our review article before Feb 26 https://t.co/jweT5FsXHL Congratulations and thanks to my wonderful co-authors!
Finally, we captured a different conformation of a Cav channel -- the N-type Cav2.2 in complex with Ziconotide, a peptide painkiller. Very proud of my brilliant postdocs Shuai and Xia https://t.co/2v2Z15KhwO
Another interesting example of AI structure prediction aiding #cryoem structure solution. Here @NiengYan@PrincetonMolBio and Chuangye Yan @Tsinghua_Uni use it to reveal fascinating insights into in-cell cholesterol sensing with a digitonin-bound SCAP/Insig-2 complex.
This is the source of funding that FBI is charging my MIT colleague, Gang Chen, of going to length to hide. I found the place where he hid it—a place called internet.
The Molecular Biology Dept @PrincetonMolBio at Princeton University invites applications for a tenure-track faculty position at the Assistant Professor level for cryo-EM/ET. Applications are accepted online at https://t.co/WKTvywPAvJ. All materials must be received by 11/1/20.
Our new work is finally out!🍻 Extended from previous results, graphene grids are applied to establish a convenient workflow for cryo-EM analysis of liposome-embedded MPs. So many thanks to Nieng and Xia! More to be explored when everything back to normal
https://t.co/On0GIwJRKx
The first Nav that I've ever worked on. A 12-year journey. Thanks to my postdoc, Dr. Shuai Gao, a chemist who found out the trick to tame NaChBac -- high pH! Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc https://t.co/GLRoX2H2qT