Minali Nigam, MD/MA

neurologist • NEJM editorial fellow • alum @Grahamheadache @harvardneuromds @BIDMC_IM @UNC_SOM @UNCHussman @DukeU • views = own

[Rahul Aggarwal @RahulAggarwalMD]

1/7 🧬Artificial intelligence could transform the clinical trial enterprise.

Trials remain the gold standard of evidence generation — yet they are slow, costly & operationally complex.

New review w/ @DLBhattMD in @EJCI_News examines how AI can reshape the trial lifecycle 🧵👇

🔗 https://t.co/A1CDL0sDUL
#ClinicalTrials #AIinMedicine

[NEJM Evidence @NEJMEvidence]

Stats, STAT!: How the Minimal Clinically Important Difference Works https://t.co/HxS1DAvWMu

#Statistics #MedEd

[NEJM Evidence @NEJMEvidence]

Clinical investigators look for statistical significance (a p-value less than 0.05) to determine if there is a difference between treatment groups. But that doesn’t necessarily mean that any such difference is clinically meaningful. Learn more: https://t.co/HxS1DAvWMu

[Minali Nigam, MD/MA @NigamMinali]

Excited to share our multimedia publication at @NEJMEvidence explaining what minimal clinically important difference means in statistical research.

Thankful for the NEJM team and their mentorship! @ChanaSacks @JeffDrazen

https://t.co/f1kUlac3xa

[NEJM @NEJM]

Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In the latest episode of Beyond Journal Club, a collaboration between @COREIMpodcast and NEJM Group, we walk through the BALANCE trial and use it as a lens to revisit how the factors of host, organism, and source should guide treatment; when is shorter really enough, and when isn’t it?

🎧 Listen to the full episode: https://t.co/lHuFPllzHf

📖 Further reading 
Original Article by N. Daneman et al.: Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections https://t.co/3Z5oQ8yrg8

[Minali Nigam, MD/MA @NigamMinali]

Such a fun episode to write & co-host as an editorial fellow @NEJM ! We talk everything bugs, bacteremia & antibiotic duration on @COREIMpodcast #antibiotics #stewardship

[CORE IM @COREIMpodcast]

1/ 🚨7 days of #Antibiotics or more??! 🤔💊

BALANCE Trial walks us through the naunces of why ID might recommend x days of abx for #bacteremia 

🎧: https://t.co/j6z3T8vaSi

[CORE IM @COREIMpodcast]

2/ Special thanks to NEJM Group and everyone who made this possible! 🎬

Authors: @ShreyaTrivediMD , @gregorykatz , @ClementLeeMD , @NigamMinali
Experts: Dr. Matt Gwiazdon 
Graphic: Dr. Jimin Hwang
Audio: Claire Yvon Ompoc Abatayo

[Rahul Aggarwal @RahulAggarwalMD]

Enjoyed presenting at #ESCCongress2025 in Madrid a pooled analysis of SCORED + SOLOIST-WHF:

✅Sotagliflozin improved HF outcomes + reduced MACE
📷Benefits consistent across ages, even >75 yrs

Important to study older adults in clinical trials

Thankful to mentor @DLBHATTMD

[Brigham and Women's Neurology @BWHNeurology]

Welcome Dr. @NigamMinali to the Division of Headache and Facial Pain and the faculty at MGB Neurology beginning in July! @GrahamHeadache @MGHNeurology

[Minali Nigam, MD/MA @NigamMinali]

As we begin the new academic year with our medical trainees, we hope our list of top 10 high yield educational articles will bring knowledge and clinical pearls to everything #headache 🧠

Honored to work with the @HeadacheJournal to bring this together 💡

[Headache Journal @HeadacheJournal]

Essential readings in #headache medicine: Top 10 educational articles for trainees from 2022–2024
Guest editorial by Assistant Editors @NigamMinali & Nan Cheng MD!
Directly access the full manuscript using the link below:
https://t.co/4q5grjhiif

[Bill Simmons @BillSimmons]

This is the best tennis shotmaking I’ve ever seen.

[US Open Tennis @usopen]

A full-circle moment!

[Coco Gauff @CocoGauff]

wow.
this means so much to me truly….french open champion🥹
i worked so hard for this moment and for it to have happened is insane. thank you God ❤️ and thank you everyone. this means the world…. I ‘m still in shock honestly can’t find the words but all I can say for now is just thank you and never give up on your dreams🫶🏾

[Roland-Garros @rolandgarros]

CARLOS ALCARAZ DID THE IMPOSSIBLE 🤯🏆

#RolandGarros

[Rahul Aggarwal @RahulAggarwalMD]

In @AnnalsofIM, we find that patients in Medicare Advantage have a similar burden of many chronic medical conditions as those in Traditional Medicare

Yet these private insurance operated Advantage plans cost $83 billion more. Could over coding of diagnoses be causing this?

Insightful thread by lead author @AndrewOseran below. Thankful to our incredible mentor @rkwadhera

https://t.co/jNUipKL2WM

[University of Utah Neurology @UofUNeurology]

Join us for Headache School in Feb! 🧠

2/18: How Can TeleMedicine Help People with Migraine? | Sara Crystal, MD
2/25: Stroke and Migraine: What's the Link? | @NigamMinali

🕕 6:30 PM (MST)
💻 Free via Zoom

🔗 For more info & to join, visit our site! https://t.co/fwfwuQHMhy

[Rahul Aggarwal @RahulAggarwalMD]

1/Our new paper on the SCORED Trial, now published @TheLancetEndo

🧵 Sotagliflozin, a dual SGLT1/2 inhibitor, improved both myocardial infarction & stroke—a benefit in both not observed with other SGLT inhibitors.

https://t.co/F0QjQjIdTg

Special thanks to ⭐️mentor @DLBHATTMD

[Minali Nigam, MD/MA @NigamMinali]

On this Valentine's Day, extend kindness to yourself & remember that every setback is a setup for a comeback. My latest is a reflection on overcoming professional rejection - hoping it resonates with anyone looking for a way to move forward. @doximity https://t.co/JHoTa7WqGn

[Andrew Pines @PinesAndrew]

What brain regions are involved in causing psychotic symptoms?

Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵

https://t.co/sBV6Lf12lR

[Marinos Sotiropoulos, MD 🇬🇷🧠 @Marinos_S]

New publication: CHANTER is an under-recognized syndrome of multifocal cerebral edema after opioid ingestion. It's important to recognize: diffusion restriction and edema are reversible and outcomes are promising!
Free copy: https://t.co/g5GBaUm49s
@DanHarrisonMD @BWHNeuroICU