I'm getting two vaccines next week: Tdap and shingles.
The Tdap because Kate's family has a newborn and we're visiting. Shingles for the potential longevity benefits.
Data we're looking at:
1. Lower Alzheimer risk with vaccination in 1.6 million people, 8 year follow up, age 65+
+ Tdap/Td: 30% lower relative risk
+ Shingles: 25% lower
+ Pneumococcal: 27% lower
2. Slower biological aging from shingles vaccination in 3,884 people, age 70+
Modest but significant improvements in inflammation, epigenetic and transcriptomic aging, and composite biological age. Molecular signals strongest within 3 years; inflammation benefits emerged later.
3. Better outcomes after breakthrough shingles in 38,092 people, age 50+, median 3.6y follow up In adults who developed shingles, prior vaccination was linked to:
+ 41% lower all-cause mortality
+ 21% lower MACE (MI, stroke, PE, sudden cardiac death)
+ 16% lower dementia risk
Note: all three studies are observational. They show association, not causation. A randomized controlled trial on longevity outcomes is not feasible here as you can't randomize people to skip vaccines for years. The signal is consistent across independent large cohorts, which strengthens confidence, but the possibility of healthy vaccine bias exists in all three. People who stay current on vaccines tend to have better health behaviors overall. I find the mechanistic case for shingles specifically compelling. VZV reactivation drives neuro inflammation, and vaccination appears to blunt that cascade which is why we weight this evidence more heavily than the numbers alone.
The Arbitrum Security Council has taken emergency action to freeze the 30,766 ETH being held in the address on Arbitrum One that is connected to the KelpDAO exploit. The Security Council acted with input from law enforcement as to the exploiter’s identity, and, at all times, weighed its commitment to the security and integrity of the Arbitrum community without impacting any Arbitrum users or applications.
After significant technical diligence and deliberation, the Security Council identified and executed a technical approach to move funds to safety without affecting any other chain state or Arbitrum users.
As of April 20 11:26pm ET the funds have been successfully transferred to an intermediary frozen wallet. They are no longer accessible to the address that originally held the funds, and can only be moved by further action by Arbitrum governance, which will be coordinated with relevant parties.
#BTCUSD monthly MACD(12,26,5) early cross just confirmed a bear market. 03 Nov 2025 previous crosses were 1 Aug 2014, 1 May 2018, 1 Nov 2019, 01 Dec 2022
#BTCUSD monthly MACD(12,26,5) early cross just confirmed a bear market. 03 Nov 2025 previous crosses were 1 Aug 2014, 1 May 2018, 1 Nov 2019, 01 Dec 2022
#BTCUSD monthly MACD(12,26,5) early cross just confirmed a bear market. 03 Nov 2025 previous crosses were 1 Aug 2014, 1 May 2018, 1 Nov 2019, 01 Dec 2022
@mythvsreality_ phytoplankton are microscopic, plant-like organisms that live in the ocean. They perform photosynthesis, just like trees and other plants, and are responsible for an estimated 50-85% of the oxygen in the atmosphere.
When Bitcoin reaches it's lowest Prices in Febuary.
Historically from 2011-2024, Bitcoin February price lows typically occur around February 5-7, averaging around February 6th.