Postdoc in the Newstead Group (@inwardopen) at the Univ. of Oxford Dept. of Biochemistry (@OxBioch), interested in Membrane Protein Structural Biology.
Happy to say our cryo-EM structure of Mtb MmpL3 is now out in @Structure_CP! (https://t.co/7DKGUi3ZLk). Thank you to all co-authors for your hard work (@justindeme85, @S_M_Lea, @philipwfowler, @inwardopen & twitterless Joanne Parker)!
Oli’s paper on the beautiful trehalose monomycolate transporter from Mycobacterium tuberculosis is now out https://t.co/t4OmbodS8x . Congratulations to the team and well done Oli! @philipwfowler@S_M_Lea@justindeme85
Excellent talk by Lizzie @LizzieDellar from the group on discovery and validation of early biomarkers in #ALS at the Oxford Neuroscience Symposium this week.
Excited to share research led by Lizzie @LizzieDellar, showing elevated levels of Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) in the CSF of asymptomatic C9orf72 HRE carriers in the absence of sustained increases in NfL #ALS#MND
https://t.co/jHY4cV44HG
First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain
https://t.co/wx48T322mz
We are excited to be here in Stockholm for #ENCALS2024! Come and check out our posters later today - see below for our presenters and poster numbers #MND#ALS
An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. https://t.co/JHeCx7weEt https://t.co/UVm6apASDk @BiochemOxford@KavliOxford
Not long to go now before I'll be running the London Landmarks Half Marathon for @spreadasmileuk - a great charity providing entertainment to children with long hospital stays. Please sponsor me if so inclined - Thanks!
https://t.co/2f7JjNk1g3
Very happy to share my first postdoc paper with @MNDOxford@NDCNOxford, together with our collaborators at @ProteomOX and @kesslerlabox. We use DIA mass spectrometry for proteomic profiling of CSF in amyotrophic lateral sclerosis for biomarker discovery. https://t.co/CTQ2VmdKeI
We are excited to be here in Barcelona for #ENCALS2023! We would be delighted to see you at our posters - see below for our presenters and poster numbers #MND#ALS
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8P6A: cryo-EM structure of human SLC15A4 in outward-open state
Newstead lab.
(SLC15A4 = a lysosome-resident, proton-coupled His transporter)
Saying ‘good journey’ to @oxkawaka and thanks for a wonderful three years fellowship with many structures and training sessions! Thanks @jsps_sns and @wellcome for funding the opportunity!
In joint second place we have Yifei Lin from @UniofOxford with a poster on ‘Structural Basis for Lipid-linked Regulation of Lysosomal CLC-7’ and Daniel Zhang from @UniofExeter with a poster on ‘Investigating the structure of archaeal virus HFTV1 using cryo-EM’. Congratulations!