Tiit Örd

Researcher; Genomics and single-cell omics

[Circulation Research @CircRes]

Perry et al found #MYH9 plays a key role in shaping fibrous, more stable #atherosclerotic plaques through sex-specific regulation of #VSMCs https://t.co/2QQzKMJKCK
@mete_civelek @Vascular_Prot @molvascular_TUM @KaikkonenLab @InnovatieHester @DiezBenavente

[Nature Cardiovascular Research @NatureCVR]

Research| Sukhavasi et al. reveal sex-specific differences in carotid stenosis. Deep single-cell sequencing shows distinct phenotypes in smooth muscle cells: osteogenic in females and chondrocytic in males, highlighting potential therapeutic targets.

[Kaikkonen Lab @KaikkonenLab]

Two MIRACLE meetings in one week! 🎉 Kick-off of MSCA-DN in Amsterdam and our EIC Consortium's Annual Meeting in Utrect. I couldn’t ask for better colleagues to share the science with! #MSCA #EIC

[Kaikkonen Lab @KaikkonenLab]

The new 10x Genomics #Xenium has arrived @UniEastFinland ! We had an insightful demo on its use and are excited about the cutting-edge spatial transcriptomics research possibilities it opens up. @AIV_Institute #10XGenomics #SpatialTranscriptomics #Research

[Mete Civelek @mete_civelek]

The first paper of 2024 is out! This is also the final paper from #RedouaneAherrahrou, who finished a very productive postdoc in my lab and now has his own group at @cardiogenetics

https://t.co/lpLk5EIoZ0

[Kaikkonen Lab @KaikkonenLab]

Our paper on the SMC-specific TRAP-Seq mouse model is finally out! This was one of the 1st projects in my lab 10 years ago before scRNA-Seq was on the scene. Great for obtaining cell type specific data more affordably. Here applied in #atherosclerosis https://t.co/1Sq1DOxcmH

[Kaikkonen Lab @KaikkonenLab]

Thrilled to launch our @EUeic project "Multiomics-based Risk Stratification for ASCVD" #MIRACLEeic Honored to work with this dedicated team!
@gpasterkamp @JBjorkegren @KiviniemiTuoski @MoritzScheidt @mm0kry @rainermpg @swvanderlaan Onland-Moret, Schunkert, Dichgans, Michoel lab

[University of Eastern Finland @UniEastFinland]

Professor Minna Kaikkonen-Määttä coordinates a multi-​national effort funded by @EUeic to combat cardiovascular disease with improved risk prediction. #MIRACLE is UEF's first EIC-funded project. @KaikkonenLab @AIV_Institute https://t.co/5aRCbMnRy2

[Kaikkonen Lab @KaikkonenLab]

Thrilled to announce our preprint describing #CoronaryArteryDisease risk variant that reduces HSF binding to shear stress responsive enhancer, dampening the expression of CALCRL in #endothelial cells @UAromLab @YunFang70204906 @heinaniemi @IlakyaSelvaraj1 https://t.co/jMijBh2As0

[Circulation Research @CircRes]

Aherrahrou & colleagues identified the expression of 84 and splicing of 164 #SmoothMuscle #genes regulated by #CAD loci. Learn more about genetic susceptibility to CAD at https://t.co/4qQCyJrVrS
@clintomics @KaikkonenLab @InnovatieHester @pksingha2020 @DiezBenavente

[Mete Civelek @mete_civelek]

The most recent work from my lab

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes https://t.co/Shpb2BufLl

[ATVB: An AHA Journal @atvbahajournals]

'rHDL nanotherapy attenuates endothelial and macrophage IFN-I response and improves post-ischemic perfusion in T2DM mice' @SYHLab @MohanBabuVenka1 @KaikkonenLab
https://t.co/IVDLsJ7mv9

[Pekka Ruusuvuori @PekkaRuusuvuori]

Great workshop yesterday with MAP-CAD consortium, funded by @SuomenAkatemia TERVA @AKA_ohjelmat. Thank you @KaikkonenLab for organizing, and @heinaniemi @tapiolonnberg @LeaMikkola @ValkonenMira and all others for presenting ongoing work & exciting results!

[Tiit Örd @OrdTiit]

@KaikkonenLab Many thanks for the kind wishes!

[EVBO @EVB_Org]

I am Tiit @OrdTiit , a senior researcher interested in interpreting coronary artery disease GWAS results using single cell omics approches.

[Kaikkonen Lab @KaikkonenLab]

Proud to present our latest preprint looking into the polygenic basis of #coronaryarterydisease using cell state signatures. Led by amazing senior researcher @OrdTiit #atherosclerosis https://t.co/vA8QxHtMQV

[Kaikkonen Lab @KaikkonenLab]

We had so much fun at the annual lab summer party! This years activities were #archerytag and #treetopadventure followed by BBQ and a dip in (still) cold lake. I love this amazing team ❤️

[Clint Miller @clintomics]

Pleased to share the first published article in our @Genes_MDPI special issue from @KaikkonenLab - The Power of Single-Cell RNA Sequencing in eQTL Discovery https://t.co/Pvq6xIh7BU @YangLabUCLA

[Casey Romanoski @UAromLab]

How do variants in the non-coding genome shape disease predisposition? Read our latest work with @KaikkonenLab finding thousands of SNPs whose alleles affect enhancer activity in human Endothelial Cells. Nearly 50% affect activity with context specificity! https://t.co/tArCHPZnTj

[Tiit Örd @OrdTiit]

As a fan of SMC gene regulation, I'm in awe of the huge work done here and proud to be a small part of it!

[Mete Civelek @mete_civelek]

This is the largest molecular QTL study performed in aortic smooth muscle cells, a key cell type in vascular disorders, such as hypertension and myocardial infarction. It was led by Dr. Redouane Aherrahrou, a postdoc fellow in the lab.