💭 Daraxonrasib - jedna z największych nadziei w leczeniu raka trzustki. Po raz pierwszy od wielu lat mamy lek, który wydłuża życie w zaawansowanym raku trzustki. Redukcja ryzyka zgonu: ⬇️ 60% (HR 0.40; 95%CI 0.3-0.54;p<0.001) - prof. @FilipMSzymanski@MZ_GOV_PL@MDobrolowicz
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
https://t.co/e04jqJMPw0
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq
@ASCO
In HER2-positive gastroesophageal adenocarcinoma, progression-free survival was longer with zanidatamab plus chemotherapy, both with and without tislelizumab, than with trastuzumab plus chemotherapy. Full HERIZON-GEA-01 trial results are summarized in a new Quick Take. https://t.co/25jpKL0oiK
Original Article: PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer (phase 3 TALAPRO-3 trial) https://t.co/NIEgLZ9cPR
Editorial: Precision Intensification in Metastatic Prostate Cancer https://t.co/BWxAVFh2ZM
#ASCO26 | @ASCO
As we age, especially after 60 years, there is a marked accumulation of mutations in our mitochondrial DNA. These are undetected (cryptic) until they expand into clones and, while associated with clonal hematopoiesis (CHIP), they may independently have an impact on health outcomes @Nature
https://t.co/fO9xmSIbDc
Published today, Vascular Contributions to Cognitive Impairment (VCID) and Brain Health: Clinical Update and Mechanistic Considerations.
This paper proposes that multi-mechanistic origins of VCID and time-appropriate interventions that complement VRFs modification are important to maintaining brain health and preserving cognitive function across the lifespan.
📷 Conceptual diagram of vascular contributions to age-related cognitive decline and worsening brain health.
Trial evidence from 17 trials in people without ASCVD including statins and non statins in 105 000 individuals about why you get a bigger benefit from starting prevention early . AJPC open access
📊Exploratory analyses of TRACE‑III
💉Tenecteplase (4.5–24h) may benefit late-window stroke patients without thrombectomy
👉❗️Effect depends on infarct growth rate
Read more here👇
https://t.co/KcktWOcqwk
New content: Understand how obesity drives MASLD/MASH. This module helps physicians recognize metabolic links, avoid delayed diagnoses, and coordinate multidisciplinary care as new therapies emerge. Access now.
▶️ https://t.co/ilRTPnnQKD
As you plan meals for your week ahead, we can with heart-smart choices. Recipes that meet Heart-Check guidelines emphasize lean ingredients, balanced nutrition, and thoughtful portions for everyday heart health. Learn more: https://t.co/jcUa0OCzqf
This case report describes a patient with left-sided weakness following transient ischemic attacks who underwent external carotid angioplasty based on findings from ultrahigh-resolution photon-counting computed tomographic angiography (CTA). https://t.co/T3N6DvjnnU
🫀 HFpEF: when the aging heart becomes inflamed, fibrotic, and stiff
HFpEF may be a clinical phenotype of accelerated cardiovascular aging — and treating the biology, not just the symptoms, may be the future.
#HFpEF#HeartFailure#Cardiology#Inflammaging
Premature menopause (age <40 years) was associated with a 40% higher lifetime risk of #CoronaryHeartDisease in both Black and White women, supporting its use as a risk-enhancing factor in preventive care. https://t.co/CEoV8jFMU9
The European Centre for Disease Prevention and Control said both STD diseases had reached their highest levels in over 10 yrs in 2024. Gonorrhoea hit 106,331 cases - a 303% increase since 2015 - while syphilis more than doubled in the same period to 45,557
https://t.co/KHuaaNPGaf