Peter Tougaard

Immunologist, fascinated by the causality of inflammatory diseases • scRNAseq • Postdoc in the Agace Lab, University of Copenhagen

[Peter Tougaard @P_Tougaard]

Exciting News: Our Paper is Published! 🎉

I’m thrilled to share that our paper, RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy, is now officially published in EMBO Reports!

[Peter Tougaard @P_Tougaard]

Interestingly, when we eliminate Caspase-8-mediated apoptosis, the mice are fully protected from the pathology. We also discovered that the microbiota plays a key role in driving intestinal elongation, while TNF is responsible for the villus atrophy. Check it out!

[Peter Tougaard @P_Tougaard]

We show that when T cells lack the TNF-signaling component RIPK1, mice develop small intestinal inflammation and intestinal elongation. This pathology mirrors what has been observed in humans with RIPK1 deficiency, making it crucial to understand how this condition develops.

[Peter Tougaard @P_Tougaard]

A special shoutout to Jelle for leading much of the research and to Wolf for performing the final experiments and addressing the rebuttal. I'm incredibly proud to be the last author on this paper and to see how the story came together.

[Peter Tougaard @P_Tougaard]

Exciting News: Our Paper is Published! 🎉

I’m thrilled to share that our paper, RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy, is now officially published in EMBO Reports!

[Peter Tougaard @P_Tougaard]

Full paper here: RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy | EMBO reports
https://t.co/ngW7cFWA4m

[Mario Ruiz Pérez @MarioRuizPrez1]

🚨Excited to share our new review in @FrontImmunol on #TCellDevelopment in the #thymus across space and time. From multipotent progenitor seeding, to commitment, differentiation, selection checkpoints, and atrophy! @VIBLifeSciences @InflamResCen
@yBIS_BE https://t.co/PeQosh8YEo

[Peter Tougaard @P_Tougaard]

@endicytosis @MarioRuizPrez1 Thanks Endi! I really enjoyed reading your recent papers :)

[Peter Tougaard @P_Tougaard]

Our paper on thymic granulopoiesis is out!! The thymus can produce neutrophils during acute thymus atrophy when Notch is downregulated. We show that TL1A and IL-18 can synergise to induce extramedullary thymic granulopoiesis in a GM-CSF-dependent manner https://t.co/kKAKpDiN34

[Peter Tougaard @P_Tougaard]

@c_maueroeder @MarioRuizPrez1 @SpringerNature @VIBFlowCoreGT @InflamResCen Not*

[Peter Tougaard @P_Tougaard]

@c_maueroeder @MarioRuizPrez1 @SpringerNature @VIBFlowCoreGT @InflamResCen Yeah, it was great having you on board. Could now have done it without you!

[Peter Tougaard @P_Tougaard]

@microgliaandme Thanks Laufey ❤️

[Peter Tougaard @P_Tougaard]

@Behrouzh_H Thanks Behrouz!

[Mario Ruiz Pérez @MarioRuizPrez1]

🎉 Exciting news! I am delighted to share that the main core of my PhD is finally available online: "TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice"!
Do you wanna know more about thymis granulopoiesis?🚀
https://t.co/G5PCqLQ7Ya
Open thread 👇🧵

[Peter Tougaard @P_Tougaard]

@lettipitko We are still trying to make it do coffee ;)

[Waggoner Lab @LabWaggoner]

TL1A and IL-18 synergism induce acute thymus atrophy while  promoting extramedullary thymic granulopoiesis in a NOTCH and GM-CSF-controlled manner @P_Tougaard @MarioRuizPrez1
https://t.co/JIJFNdTAkY

[Peter Tougaard @P_Tougaard]

Special thanks to Jelle and Wolf, who does not have twitter, but made this story possible! @SpringerNature @cddpress @InflamResCen

[Peter Tougaard @P_Tougaard]

Super excited to share our new paper! We show that T cells require the protein RIPK1 to survive after exiting the thymus to avoid TNF-mediated apoptosis. This was a great effort, Thanks to everybody involved! 🥳 #cdd https://t.co/kH7nIx1g2b

[Mario Ruiz Pérez @MarioRuizPrez1]

🎉 Excited to share the team's latest publication in @SpringerNature @CDDpress! Thrilled to have been part of this big effort. @InflamResCen

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

https://t.co/pH2qBkEJF9

[Peter Tougaard @P_Tougaard]

@TerkildB Thank you for your input along the way, Terkild, and for teaching me how to perform the thymus organ culture!

[Peter Tougaard @P_Tougaard]

Super proud of this paper! We show that the thymus is more than a T cell producer, and during type 1 immunity can produce peripheral homing ILC1s! https://t.co/JjQZtAnJr3