Patrick Kilroy

[Patrick Kilroy @PaddyKilroy]

@StephenSeiler Enjoy!

[Patrick Kilroy @PaddyKilroy]

@SwPrayer Amen

[Patrick Kilroy @PaddyKilroy]

@sscjusa Thank you. God bless!

[Patrick Kilroy @PaddyKilroy]

@CatholicRunners @Alan_Couzens No day off? My wife insists that I respect the Sabath on Sunday.

[Patrick Kilroy @PaddyKilroy]

@Matt_Pinner A. Yes, several.

[Patrick Kilroy @PaddyKilroy]

@patrickmadrid Amazing! I often say a quick thank you to my Guardian Angel when I “miraculously “ avoid a mishap of some sort.

[Patrick Kilroy @PaddyKilroy]

@StephenSeiler Heal swiftly!

[Patrick Kilroy @PaddyKilroy]

@EWTNews @JamesMartinSJ Wow!

[Patrick Kilroy @PaddyKilroy]

@patrickmadrid Powerful article. Frightening for our children and grandchildren!

[Patrick Kilroy @PaddyKilroy]

@minihan8 @fathertomhoar 🙏

[Patrick Kilroy @PaddyKilroy]

@Maryamart011 AMEN!

[Earth @earthcurated]

Winter in Yosemite ❄️

[Shayan @shayan_]

I’m devastated. A good friend and dormmate of mine, Amin Pourfarhang, has been sentenced to death after protesting in Iran 😭 He’s one of the kindest people I’ve ever known.

Please share. Visibility raises the cost for the Islamic Republic and may stop this execution!

[Patrick Kilroy @PaddyKilroy]

@VintageHoops Sad

[Patrick Kilroy @PaddyKilroy]

@Matt_Pinner 6

[Patrick Kilroy @PaddyKilroy]

@AscensionPress 🙏

[Patrick Kilroy @PaddyKilroy]

@sophia_artx 11

[Iñigo San Millán @doctorinigo]

Among the many effects of lactate in metabolism, Lactate has important endocrine and autocrine roles in fat metabolism

Endocrine: Lactate leaves the muscle and acts as a hormone. It reaches adipose tissue, binds to the GPR81 receptor, and tells fat cells to slow lipolysis. This is a whole body signal. One tissue sends a message, another tissue changes its behavior. (Liu et al, 2009) https://t.co/3XOWJZlbeN

Autocrine: Inside the muscle, lactate regulates its own environment. It can reduce CPT1 and CPT2 activity, limit fatty acid entry into mitochondria, shift redox balance, increase ROS, and lower ATP production. This changes how the muscle cell uses fat at the mitochondrial level. (San-Millan et al, 2022) https://t.co/tc7dNMhflN

Lactate is a powerful messenger that coordinates fat metabolism from the outside and the inside.

[Patrick Kilroy @PaddyKilroy]

@_AshleyRichmond Send

[Patrick Kilroy @PaddyKilroy]

@theamelia__ HOPE