Iโm devastated. A good friend and dormmate of mine, Amin Pourfarhang, has been sentenced to death after protesting in Iran ๐ญ Heโs one of the kindest people Iโve ever known.
Please share. Visibility raises the cost for the Islamic Republic and may stop this execution!
Among the many effects of lactate in metabolism, Lactate has important endocrine and autocrine roles in fat metabolism
Endocrine: Lactate leaves the muscle and acts as a hormone. It reaches adipose tissue, binds to the GPR81 receptor, and tells fat cells to slow lipolysis. This is a whole body signal. One tissue sends a message, another tissue changes its behavior. (Liu et al, 2009) https://t.co/3XOWJZlbeN
Autocrine: Inside the muscle, lactate regulates its own environment. It can reduce CPT1 and CPT2 activity, limit fatty acid entry into mitochondria, shift redox balance, increase ROS, and lower ATP production. This changes how the muscle cell uses fat at the mitochondrial level. (San-Millan et al, 2022) https://t.co/tc7dNMhflN
Lactate is a powerful messenger that coordinates fat metabolism from the outside and the inside.