Check out the article featured in @ChemistryWorld on the photostiching of nitroalkanes. The transformation not only brought two coupling partners together to generate a strong bond, but it also brought two labs together (@ParasramLab and @reiser_group) to form a strong friendship
Congrats to Postdoc Researcher Dr. Ajay Bansode on starting his new position as a Senior Scientist at Avinthia, Inc. You will be missed! May the force be with you!
Celebrating the happy ending of our photostiching studies of nitroalkanes: back to back publication together with @ParasramLab in @J_A_C_S. Thank you @nyuniversity for your hospitality. https://t.co/K4GvsyQ4FZ
Cheers to Dr. Alana Duke! The fourth Jedi Knight of the
@ParasramLab! Dr. Duke will pursue her postdoctoral studies at Northwestern University with the
@kalowlab! May the force be with you!
Visible light knits nitroalkanes into alkenes and @ParasramLab and our group together. Thank you @cenmag for the nice write up, it is an honor. https://t.co/K4GvsyPwQr
๐ ๐๐จ๐ง๐ ๐ซ๐๐ญ๐ฎ๐ฅ๐๐ญ๐ข๐จ๐ง๐ฌ ๐ญ๐จ ๐๐๐ซ๐ฏ๐ข๐ง ๐๐๐ซ๐๐ฌ๐ซ๐๐ฆ, ๐๐จ๐ฌ๐ก๐ฎ๐ ๐. ๐๐ข๐ญ๐๐ก๐๐ฅ๐ฅ, ๐๐ง๐ ๐๐จ-๐ฐ๐จ๐ซ๐ค๐๐ซ๐ฌ ๐จ๐ง ๐ญ๐ก๐๐ข๐ซ ๐ง๐๐ฐ ๐๐๐๐ ๐ฉ๐ฎ๐๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง: โ๐๐ก๐จ๐ญ๐จ-๐๐ญ๐ข๐ญ๐๐ก๐ข๐ง๐ ๐จ๐ ๐๐ข๐ญ๐ซ๐จ๐๐ฅ๐ค๐๐ง๐๐ฌ ๐ฏ๐ข๐ ๐๐ซ๐จ๐ฌ๐ฌ-๐๐๐ง๐ข๐ญ๐ซ๐๐ญ๐ข๐ฏ๐ ๐๐ฅ๐๐๐ข๐ง๐๐ญ๐ข๐จ๐งโ!
https://t.co/XUSToi5UGe
๐ฌ This study reports the first direct cross- and self-olefination of nitroalkanes under simple conditions using only a base and visible-light irradiation, providing an efficient route to sterically congested tri- and tetrasubstituted alkenes.
Visible-light irradiation of in situ generated nitronates enabled cross-denitrative olefination through a unique photo-stitching process.
A broad range of functionalized nitroalkanes, including carbonyl- and heterocycle-containing substrates, were well tolerated.
๐ก The method provides a practical complement to classical olefination and alkene metathesis for the synthesis of highly substituted alkenes.
Mechanistic studies revealed a photoinitiated radical-chain process in which nitronates act as photoreductants, followed by a photodriven ฮฒ-elimination.
This work establishes nitronates as versatile photoreductants and coupling partners, opening new opportunities for light-driven radical-mediated olefination.
๐ We are pleased to see that some nitroalkane substrates used in this study were sourced from AmBeed. In the graphic below, the corresponding ๐๐บ๐๐ฒ๐ฒ๐ฑ ๐๐ฎ๐. ๐ก๐ผ๐. are highlighted in orange.
๐ง๐ฟ๐ ๐๐บ๐๐ฒ๐ฒ๐ฑโ๐ ๐ป๐ถ๐๐ฟ๐ผ๐ฎ๐น๐ธ๐ฎ๐ป๐ฒ๐ ๐ถ๐ป ๐๐ผ๐๐ฟ ๐ฟ๐ฒ๐๐ฒ๐ฎ๐ฟ๐ฐ๐ต.
https://t.co/fu7gQT67nS
#AmBeed #JACS #OrganicChemistry #Nitroalkanes #Olefination #Photochemistry #VisibleLight #BuildingBlocks #ResearchTools #Paper #Chemistry
Also, check out related work from Prof. Oliver Reiser (@reiser_group) on the photoredox-promoted cross-coupling of nitroalkanes leading to olefins. https://t.co/evGG5PhSIP
Need a method to synthesize tri- or tetrasubstituted alkenes? Check our recent work published in @J_A_C_S on the photo-stitching of nitroalkanes. The transformation proceeds via SRN1โERC1 mechanism of photogenerated nitronates. @nyuchemistry@NYUScience https://t.co/ycLCzZs2mI
Shoutout to newly minted Dr. Joshua Paolillo! The third Jedi Knight of the Parasram Lab! Dr. Paolillo will pursue his postdoctoral studies at @uncchemistry with the @LeibfarthGroup! May the force be with you!
Introducing Dr. Joshua Mitchell! The second Jedi Knight of the Parasram Lab! Dr. Mitchell will pursue his postdoctoral studies at @CaltechCCE with the Fu Lab! May the force be with you! Congrats!
Congrats to Dr. @Emma_Gogarnoiu! The first Jedi Knight of the @ParasramLab! Dr. Gogarnoiu will pursue her postdoctoral studies at Princeton University with the @MacMillan_Lab! May the force be with you!
Complementing the McMurry Coupling and Alkene Metathesis: Photocatalytic denitrative homo- and cross-coupling of nitroalkanes towards the synthesis of alkenes: https://t.co/jzy0KIMfWA. See the parallel submission by @ParasramLab, the same but not the same ๐
Check out what our lab and the @reiser_group stitched together contemporaneously. Both labs report a new olefination method via denitrative cross-coupling of readily accessible nitroalkanes on @ChemRxiv Parasram (image): https://t.co/h1d4v3Jj7L. Reiser: https://t.co/ZIZhKImj8M