Pasquale Piccolo

Assistant Investigator at @Tigem_Telethon

[Pasquale Piccolo @Pas_Piccolo]

@MolTherapy @brunetti_pierri Key insights:
-miR-34b/c-KO mice show heightened susceptibility to fibrotic damage.
-delivery to hepatocytes of miR-34b/c by AAV reverses fibrosis in TAA- and CCl₄-induced models.
-the anti-fibrotic effect of miR-34b/c is cell-autonomous to hepatocytes and is PDGFRα/β-dependent

[Pasquale Piccolo @Pas_Piccolo]

Our latest work is now out in @MolTherapy
Nucleic Acids! Hepatocyte delivery of miR-34b/c reduces hepatic stellate cell activation and improves liver fibrosis. Huge thanks to Rosa Ferriero, @brunetti_pierri and all our collaborators https://t.co/CfVw36U2Bp

[Pasquale Piccolo @Pas_Piccolo]

@MolTherapy @brunetti_pierri Liver fibrosis, affecting millions worldwide, has no treatment options. We demonstrated that targeted delivery of miR-34b/c to hepatocytes via AAV vectors reduces fibrosis by modulating PDGF signaling and suppressing hepatic stellate cell activation, key drivers of fibrogenesis.

[Pasquale Piccolo @Pas_Piccolo]

Our work exploring the limitations and opportunities of #AAV-mediated gene transfer in #fibrotic livers is now online in #NatureCommunications! Huge thanks to Rosa Ferriero, @GemBruno , and all our collaborators for their invaluable contributions.

https://t.co/xmeHMBV5So

[World Federation of Hemophilia @wfhemophilia]

At the New Technology and #GeneTherapy workshop, experts @AravindAsokan, @Pas_Piccolo, @DavidLillicrap, @DrSamelsonJones & more, shared groundbreaking research on immunological challenges & innovative treatments. The future of #hemophilia treatment is full of exciting potential!

[Francesca Zappa @Frances43977343]

Great viewpoint from scientists and my stellar friend @mc_masone about the often underrated challenges of being a non-native English in science.
Most of us can relate!

[Tigem Telethon @Tigem_Telethon]

👨‍🔬 We are pleased to introduce @Pas_Piccolo, Assistant Investigator at TIGEM. One of his most interesting research interests concerns hepatocyte-directed #GeneTherapy for inherited disorders with #LiverFibrosis.

🔗 More about his research interests here:
https://t.co/xkQGFL6hye

[Pasquale Piccolo @Pas_Piccolo]

Postdoctoral position on liver-directed gene-based therapies available in my lab! #postdoc #postdoctoral #genetherapy #genomeediting #AAV #liver

[Tigem Telethon @Tigem_Telethon]

⚠️ A new postdoctoral position is available in @Pas_Piccolo's Lab.

🔗 More informations here:
https://t.co/wbSBy9cIz6

#jobalert #postdoc

[Pasquale Piccolo @Pas_Piccolo]

The result of the collaborative effort between @msnacht's team at @logicbio Therapeutics and my lab at @Tigem_Telethon on #genomeediting for #Wilsondisease is finally out! Have a look at it in @JCI_insight

[Pasquale Piccolo @Pas_Piccolo]

@nicdepris @AlexGennarino Well deserved!

[Tigem Telethon @Tigem_Telethon]

🧬 @Pas_Piccolo is now presenting his talk at AATD 2023 meeting!
#aatd2023 #tigem #AATdeficiency #liverfibrosis #geneticdiseases

[Pasquale Piccolo @Pas_Piccolo]

Let's get started! #AATD2003 #A1AT #antitrypsindeficiency

[Tigem Telethon @Tigem_Telethon]

⚠️ AATD 2023 meeting has just started! ⚠️
#Tigem #meeting #aatd

[Fondazione Telethon @Fondaz_Telethon]

Coordinatore provinciale Telethon a Napoli, Referente di direzione del @CentroNemo Napoli. Ma la storia di Francesco racconta tanto altro. Un percorso fatto di capacità ed energie spese per la sua comunità. Senza fermarsi mai, con risultati straordinari
https://t.co/s2r0HTx7jZ

[Tigem Telethon @Tigem_Telethon]

#SeniorResearcher #jobopportunities
Brunetti-Pierri's Lab is looking for senior researcher to be involved in the Project "Gene Therapy and Innovative Therapies in Pediatrics".

For more info check 👇
https://t.co/ANKkTfhhG4

@AornSantobono

[Pasquale Piccolo @Pas_Piccolo]

@gem_bru

[Tigem Telethon @Tigem_Telethon]

‼️Now out a new study by @brunetti_pierri group on
@CellPressNews.

"Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin" 👇🏻
https://t.co/ALHKPTCcO8

[Pasquale Piccolo @Pas_Piccolo]

A great three-day full immersion in Serpin biology #euroserpin2023 #alpha1antitrypsin #AATD #serpinopathies

[Pasquale Piccolo @Pas_Piccolo]

@francio_pana @VolpeMariagr Congratulazioni Francesco!

[Tigem Telethon @Tigem_Telethon]

Anche il Telethon Institute of Genetics and Medicine #Tigem festeggia il grande successo del #Napoli per il terzo scudetto!
Congratulazioni alla @sscnapoli e ora insieme portiamo la città sempre più in alto!
#napolicampioneditalia #NapoliCampione #NAPOLISCUDETTO

[Official SSC Napoli @sscnapoli]

Il sogno ora è realtà: Napoli torna Campione! #Napul3

💙 #ForzaNapoliSempre #TuttoPerLei